KEGG   PATHWAY: fpg04530
Entry
fpg04530                    Pathway                                
Name
Tight junction - Falco peregrinus (peregrine falcon)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fpg04530  Tight junction
fpg04530

Other DBs
GO: 0005923
Organism
Falco peregrinus (peregrine falcon) [GN:fpg]
Gene
101910490  CLDN11; claudin 11 [KO:K06087]
101910508  [KO:K06087]
101910698  [KO:K06087]
101910777  JAM2; junctional adhesion molecule 2 [KO:K06735]
101910866  CLDN4; claudin-4 [KO:K06087]
101910898  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
101910953  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
101911044  CLDN3; claudin-3 [KO:K06087]
101911178  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101911200  RHOA; ras homolog family member A [KO:K04513]
101911552  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101911603  [KO:K12755]
101911648  [KO:K06093]
101911665  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
101911845  SYNPO; synaptopodin [KO:K21112]
101912031  TJP1; tight junction protein 1 [KO:K05701]
101912082  ACTN1; actinin alpha 1 [KO:K05699]
101912140  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101912484  [KO:K06087]
101912570  TJAP1; tight junction associated protein 1 [KO:K06105]
101912716  ACTB; actin beta [KO:K05692]
101912795  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101912808  CLDN2; claudin 2 [KO:K06087]
101913169  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
101913234  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
101913286  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
101913337  AMOTL2; angiomotin like 2 [KO:K06104]
101913406  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
101913433  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
101913632  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
101913634  BVES; blood vessel epicardial substance [KO:K21108]
101913786  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
101913819  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
101913859  TJP2; tight junction protein 2 [KO:K06098]
101913874  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
101914235  TJP3; tight junction protein 3 [KO:K06097]
101914291  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
101914344  DLG3; discs large MAGUK scaffold protein 3 [KO:K21098]
101914383  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
101914384  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
101914467  [KO:K06087]
101914680  [KO:K07374]
101914722  ARHGEF18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
101914726  [KO:K06093]
101914857  [KO:K07374]
101914860  MARVELD2; MARVEL domain containing 2 [KO:K17291]
101914879  CDC42; cell division cycle 42 [KO:K04393]
101914926  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
101914937  CCND1; cyclin D1 [KO:K04503]
101914958  EZR; ezrin [KO:K08007]
101914980  CLDN10; claudin 10 [KO:K06087]
101915063  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
101915115  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
101915187  MSN; moesin [KO:K05763]
101915208  SCRIB; scribbled planar cell polarity protein [KO:K16175]
101915456  [KO:K07374]
101915476  CLDN14; claudin 14 [KO:K06087]
101915617  CLDN5; claudin 5 [KO:K06087]
101915633  CTTN; cortactin [KO:K06106]
101915668  NF2; neurofibromin 2 [KO:K16684]
101915683  MYH10; myosin heavy chain 10 [KO:K10352]
101915714  MICALL2; MICAL like 2 [KO:K21068]
101915912  JAM3; junctional adhesion molecule 3 [KO:K06785]
101916254  GATA4; GATA binding protein 4 [KO:K09183]
101916325  MYH9; myosin heavy chain 9 [KO:K10352]
101916329  RUNX1; runt related transcription factor 1 [KO:K08367]
101916357  [KO:K07374]
101916393  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
101916491  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
101916533  MYL2; myosin light chain 2 [KO:K10351]
101916595  AMOT; angiomotin [KO:K16819]
101916633  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
101916654  [KO:K06087]
101916787  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
101916795  CLDN20; claudin 20 [KO:K06087]
101916959  OCLN; occludin [KO:K06088]
101916990  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101916999  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
101917138  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
101917234  CLDN16; claudin 16 [KO:K06087]
101917395  ITGB1; integrin subunit beta 1 [KO:K05719]
101917411  CLDN1; claudin 1 [KO:K06087]
101917447  CLDN23; claudin 23 [KO:K06087]
101917483  CLDN18; claudin 18 [KO:K06087]
101917502  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
101917527  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
101917743  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
101917755  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
101918159  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
101918379  CGNL1; cingulin like 1 [KO:K21110]
101918707  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
101918818  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
101918959  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
101919295  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
101919502  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
101919506  ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2 [KO:K12791]
101919774  ACTG1; actin gamma 1 [KO:K05692]
101919791  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
101919848  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
101919887  MPP4; membrane palmitoylated protein 4 [KO:K21109]
101920148  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
101920342  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
101920379  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
101920529  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
101920538  [KO:K06087]
101920625  CLDN12; claudin 12 [KO:K06087]
101920701  CD1A; T-cell surface glycoprotein CD1b-3 [KO:K06448]
101920842  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
101920917  RDX; radixin [KO:K05762]
101921076  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101921211  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
101921274  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
101921275  PCNA; proliferating cell nuclear antigen [KO:K04802]
101921306  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
101921471  [KO:K16684]
101921472  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
101921738  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
101921803  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101921847  MYL12B; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
101921929  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101921932  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
101922110  CGN; cingulin [KO:K06102]
101922135  [KO:K12757]
101922375  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
101922397  AMOTL1; angiomotin like 1 [KO:K06104]
101922409  PARD3; par-3 family cell polarity regulator [KO:K04237]
101922639  AFDN; afadin, adherens junction formation factor [KO:K05702]
101922901  CLDN25; claudin 25 [KO:K06087]
101922941  [KO:K21099]
101922942  [KO:K07374]
101923086  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
101923111  [KO:K07374]
101923113  [KO:K07374]
101923271  RHOC; ras homolog family member C [KO:K04513]
101923298  CLDN19; claudin 19 [KO:K06087]
101923814  YBX3; Y-box binding protein 3 [KO:K06099]
101923844  F11R; F11 receptor [KO:K06089]
101923881  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
101923933  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
101923975  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
101924077  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
101924094  TUBA1C; tubulin alpha-3 chain [KO:K07374]
101924129  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101924219  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101924330  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
101924468  MYH11; myosin heavy chain 11 [KO:K10352]
101924486  CLDN34; claudin 34 [KO:K06087]
101924526  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
101924846  [KO:K05692]
101924871  MPP5; membrane palmitoylated protein 5 [KO:K06091]
106112377  [KO:K07374]
106112384  MARVELD3; MARVEL domain containing 3 [KO:K21099]
106112951  [KO:K08367]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
fpg04520  Adherens junction
fpg04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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