KEGG   PATHWAY: gacu04530
Entry
gacu04530                   Pathway                                
Name
Tight junction - Gymnodraco acuticeps
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gacu04530  Tight junction
gacu04530

Other DBs
GO: 0005923
Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117532364  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117532607  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117532640  [KO:K04503]
117532696  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
117532748  zgc:154006; occludin isoform X1 [KO:K06088]
117532778  ocel1; occludin/ELL domain-containing protein 1 [KO:K17291]
117532941  bves; blood vessel epicardial substance [KO:K21108]
117532975  [KO:K05702]
117533213  pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
117533250  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
117533285  cgnl1; cingulin-like protein 1 [KO:K21110]
117533378  [KO:K06106]
117533412  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117533773  actn1; alpha-actinin-1 [KO:K05699]
117533810  gata4; transcription factor GATA-4 [KO:K09183]
117533889  jam3a; junctional adhesion molecule C [KO:K06785]
117534072  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117534181  [KO:K04353]
117534213  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117534531  cldn2; LOW QUALITY PROTEIN: claudin-2 [KO:K06087]
117534575  [KO:K07374]
117534588  [KO:K07374]
117534596  [KO:K05692]
117534604  [KO:K05692]
117534613  [KO:K05692]
117534622  [KO:K05692]
117534861  map3k5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117534935  magi1b; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b [KO:K05631]
117534963  [KO:K06098]
117535013  [KO:K05692]
117535020  [KO:K04382] [EC:3.1.3.16]
117535147  [KO:K17260]
117535378  [KO:K05731]
117535784  si:dkey-98f17.3; putative claudin-24 [KO:K06087]
117536065  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
117536185  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
117536791  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117536964  sympk; symplekin [KO:K06100]
117537018  arhgef1a; rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
117537244  myh11a; LOW QUALITY PROTEIN: myosin-11a [KO:K10352]
117537368  [KO:K07374]
117537369  [KO:K07374]
117537370  [KO:K07374]
117537371  [KO:K07374]
117537386  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117537577  dlg3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
117537656  rap2c; ras-related protein Rap-2c [KO:K07839]
117537882  [KO:K10352]
117537936  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117537959  [KO:K10352]
117537983  si:dkey-92j12.5; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
117538077  [KO:K05762]
117538345  tuba8l3; tubulin, alpha 8 like 3 [KO:K07374]
117538346  [KO:K07374]
117538350  [KO:K07374]
117538858  tjp1b; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
117538922  [KO:K21110]
117538970  [KO:K07902]
117539054  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117539156  [KO:K06087]
117539227  cldn15a; claudin-15a [KO:K06087]
117539269  mpp4b; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
117539357  [KO:K18584]
117539537  [KO:K05704] [EC:2.7.10.2]
117539718  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
117539958  [KO:K04354]
117540032  [KO:K06087]
117540088  rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
117540096  [KO:K06087]
117540097  [KO:K06087]
117540098  [KO:K06087]
117540134  [KO:K06087]
117540135  [KO:K06087]
117540139  [KO:K06087]
117540140  [KO:K06087]
117540164  nf2b; neurofibromin 2b (merlin) [KO:K16684]
117540167  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117540168  [KO:K06087]
117540194  hspa4a; heat shock 70 kDa protein 4a [KO:K09489]
117540212  [KO:K06087]
117540239  [KO:K06087]
117540243  [KO:K06087]
117540361  cldn8; claudin-8 [KO:K06087]
117540368  [KO:K05731]
117540369  zgc:110333; claudin-8 [KO:K06087]
117540370  [KO:K06087]
117540966  [KO:K13365]
117541017  rab13; ras-related protein Rab-13 [KO:K06109]
117541114  [KO:K07901]
117541183  oclnb; occludin b [KO:K06088]
117541203  marveld2b; MARVEL domain-containing protein 2b [KO:K17291]
117541242  cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
117541276  cldn5b; claudin-5b [KO:K06087]
117541324  si:ch73-61d6.3; occludin isoform X1 [KO:K06088]
117541396  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117541505  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
117541597  [KO:K18050] [EC:2.7.11.13]
117541780  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117541781  [KO:K21066]
117541789  zgc:153867; myosin light polypeptide 6 [KO:K12751]
117541859  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117541921  [KO:K07901]
117542099  [KO:K04513]
117542174  myl12.2; myosin, light chain 12, genome duplicate 2 isoform X1 [KO:K12757]
117542328  [KO:K17260]
117542386  [KO:K07200]
117542436  [KO:K12076]
117542441  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117542620  cgnb; cingulin isoform X1 [KO:K06102]
117542978  [KO:K04393]
117542991  [KO:K05631]
117543430  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
117543712  [KO:K05755]
117543904  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117543963  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
117544124  slc9a3r1b; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
117544213  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
117544433  [KO:K06087]
117544436  [KO:K06087]
117544444  [KO:K06087]
117544539  jam2b; junctional adhesion molecule 2b [KO:K06735]
117544566  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
117544682  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117544777  scrib; protein scribble homolog isoform X1 [KO:K16175]
117544903  rac1a; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117544977  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117545207  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117545345  amot; angiomotin isoform X1 [KO:K16819]
117545363  [KO:K04393]
117545389  [KO:K06087]
117545504  cldn18; claudin-18 [KO:K06087]
117545505  cldn1; claudin-1 [KO:K06087]
117545557  [KO:K04448]
117545976  [KO:K04513]
117546437  [KO:K07374]
117546565  cldn10a; claudin-10a [KO:K06087]
117546623  runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
117546642  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117546686  si:busm1-52i16.2; claudin-10 [KO:K06087]
117546687  si:ch211-181l5.2; claudin-10 [KO:K06087]
117546689  [KO:K06087]
117546872  [KO:K21109]
117546884  [KO:K05762]
117546918  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117546941  jam2a; junctional adhesion molecule 2a isoform X1 [KO:K06735]
117546946  tjp1a; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
117547201  cldn15la; LOW QUALITY PROTEIN: claudin 15-like a [KO:K06087]
117547211  [KO:K21066]
117547451  wasb; LOW QUALITY PROTEIN: WASP actin nucleation promoting factor b [KO:K05747]
117547588  [KO:K18584]
117547683  [KO:K07374]
117547686  [KO:K04513]
117547727  pard6b; partitioning defective 6 homolog beta [KO:K06093]
117548197  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117548381  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
117548426  crb3a; protein crumbs homolog 3a [KO:K06090]
117548428  [KO:K04345] [EC:2.7.11.11]
117548670  cldni; claudin i [KO:K06087]
117548701  cldnk; claudin k [KO:K06087]
117548709  micall2a; MICAL-like protein 2a isoform X1 [KO:K21068]
117548722  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
117549035  ezra; ezrin a [KO:K08007]
117549328  [KO:K20479]
117549768  llgl2; LLGL scribble cell polarity complex component 2 [KO:K06094]
117549865  [KO:K06087]
117550227  pard3aa; partitioning defective 3 homolog isoform X1 [KO:K04237]
117550231  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
117550655  [KO:K07200]
117550656  [KO:K18584]
117550760  [KO:K05763]
117551055  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117551057  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117551071  [KO:K04513]
117551085  myl6; myosin light polypeptide 6 [KO:K12751]
117551252  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117551262  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117551327  marveld2a; MARVEL domain-containing protein 2 [KO:K17291]
117551333  oclna; occludin [KO:K06088]
117551499  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
117551637  igsf5b; LOW QUALITY PROTEIN: immunoglobulin superfamily member 5 [KO:K06786]
117551692  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117551817  cdc42l; cell division cycle 42, like [KO:K04393]
117552072  nf2a; neurofibromin 2a (merlin) isoform X1 [KO:K16684]
117552197  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117552911  jam3b; junctional adhesion molecule 3B [KO:K06785]
117552937  cldn7b; claudin-7-B [KO:K06087]
117552940  [KO:K05763]
117553081  [KO:K06786]
117553379  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
117553438  [KO:K21068]
117553597  rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
117553685  [KO:K05719]
117553980  cldn12; claudin-12 [KO:K06087]
117554050  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
117554070  [KO:K06102]
117554692  [KO:K12076]
117554752  cldn23a; claudin-23 [KO:K06087]
117554928  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
117555068  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
117555089  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117555105  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117555177  [KO:K06087]
117555214  jun; transcription factor AP-1 [KO:K04448]
117555489  zgc:101810; actin-related protein 2 [KO:K17260]
117555605  cldnf; claudin f [KO:K06087]
117555606  [KO:K06087]
117555607  cldnj; claudin j [KO:K06087]
117555610  [KO:K06087]
117555611  [KO:K06087]
117555623  [KO:K06087]
117555652  [KO:K06087]
117555660  [KO:K06087]
117555661  [KO:K06087]
117555917  [KO:K04354]
117555963  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117556011  [KO:K04382] [EC:3.1.3.16]
117556037  hspa4b; heat shock 70 kDa protein 4b isoform X1 [KO:K09489]
117556212  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117556221  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117556245  actb1; actin, cytoplasmic 1 [KO:K05692]
117556431  si:dkey-221l4.11; claudin-23 [KO:K06087]
117556483  [KO:K10352]
117556533  [KO:K17388] [EC:2.7.11.39]
117556578  [KO:K07374]
117556668  cldn34a; claudin-34 [KO:K06087]
117556672  [KO:K06087]
117556990  [KO:K21112]
117557093  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
117557158  [KO:K10352]
117557197  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117557217  dlg2; LOW QUALITY PROTEIN: disks large homolog 2 [KO:K12075]
117557335  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117557363  [KO:K10352]
117557427  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117557733  [KO:K06087]
117558377  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
117558399  [KO:K07200]
117558437  [KO:K06104]
117558492  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
117558813  [KO:K06095]
117558834  cldn11a; claudin-11a [KO:K06087]
117559056  amotl2a; angiomotin-like 2a isoform X1 [KO:K06104]
117559065  [KO:K06087]
117559154  hcls1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
117559464  cldn7a; claudin-7-A [KO:K06087]
117559500  [KO:K04393]
117559860  cldn19; claudin-19 isoform X1 [KO:K06087]
117560117  [KO:K06087]
117560477  si:ch211-191a24.4; LOW QUALITY PROTEIN: MARVEL domain-containing protein 3 [KO:K21099]
117560643  [KO:K04237]
117560810  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
117561079  cldn5a; claudin 5a [KO:K06087]
117561313  pcna; proliferating cell nuclear antigen [KO:K04802]
117561518  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
117561581  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117561648  [KO:K06087]
117561826  [KO:K07374]
117561828  [KO:K07374]
117561898  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117562332  ezrb; ezrin b isoform X1 [KO:K08007]
117562342  mpp5b; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 5b [KO:K06091]
117562684  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
117562693  [KO:K06087]
117563109  [KO:K06091]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
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Nat Rev Mol Cell Biol 15:225-42 (2014)
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Related
pathway
gacu04520  Adherens junction
gacu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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