KEGG   PATHWAY: gaf00830
Entry
gaf00830                    Pathway                                
Name
Retinol metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
gaf00830  Retinol metabolism
gaf00830

Other DBs
GO: 0006776
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122824343  bco1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
122827072  bco1l; beta-carotene oxygenase 1, like [KO:K00515] [EC:1.13.11.63]
122846667  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122846668  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122846671  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122836534  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122836535  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122833705  dhrs3b; short-chain dehydrogenase/reductase 3b [KO:K11146] [EC:1.1.1.300]
122820062  dhrs4; dehydrogenase/reductase SDR family member 4 isoform X1 [KO:K11147] [EC:1.1.-.-]
122838148  zgc:109982; retinol dehydrogenase 8 isoform X1 [KO:K11150] [EC:1.1.1.-]
122821559  rdh8a; retinol dehydrogenase 8a [KO:K11150] [EC:1.1.1.-]
122821563  zmp:0000001048; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
122829476  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
122824269  rdh10a; retinol dehydrogenase 10-A [KO:K11151] [EC:1.1.1.-]
122834637  rdh20; retinol dehydrogenase 10-B [KO:K11151] [EC:1.1.1.-]
122845801  rdh12; retinol dehydrogenase 12 isoform X1 [KO:K11153] [EC:1.1.1.300]
122823980  rdh12l; retinol dehydrogenase 12, like [KO:K11153] [EC:1.1.1.300]
122830875  si:dkey-23o4.6; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
122824538  retinol dehydrogenase 12-like [KO:K11153] [EC:1.1.1.300]
122824539  retinol dehydrogenase 11-like isoform X1 [KO:K11153] [EC:1.1.1.300]
122835747  retinol dehydrogenase 11-like isoform X1 [KO:K11153] [EC:1.1.1.300]
122822860  si:ch211-107o10.3; retinol dehydrogenase 13 [KO:K11153] [EC:1.1.1.300]
122822750  retinol dehydrogenase 13-like isoform X1 [KO:K11161] [EC:1.1.1.300]
122840782  epidermal retinol dehydrogenase 2-like isoform X1 [KO:K15734] [EC:1.1.1.105]
122830425  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
122821042  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
122821063  lratb.2; lecithin retinol acyltransferase b, tandem duplicate 2 [KO:K00678] [EC:2.3.1.135]
122831501  diacylglycerol O-acyltransferase 1-like [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
122843123  dgat1a; diacylglycerol O-acyltransferase 1a [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
122827168  pnpla4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
122839182  retinal Mueller cells isomerohydrolase-like [KO:K11158] [EC:3.1.1.64 5.3.3.22]
122841139  rpe65a; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
122833903  rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
122827269  aox6; aldehyde oxidase 6 isoform X1 [KO:K00157] [EC:1.2.3.1]
122846329  aldh1a3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
122843682  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
122823129  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
122820272  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
122842802  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
122842051  cytochrome P450 3A30-like [KO:K07424] [EC:1.14.14.1]
122842281  cytochrome P450 3A40-like [KO:K07424] [EC:1.14.14.1]
122842285  cytochrome P450 3A19-like isoform X1 [KO:K07424] [EC:1.14.14.1]
122829005  cytochrome P450 3A56-like [KO:K07424] [EC:1.14.14.1]
122829006  cytochrome P450 3A30 [KO:K07424] [EC:1.14.14.1]
122829007  cytochrome P450 3A40-like isoform X1 [KO:K07424] [EC:1.14.14.1]
122844497  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
122844498  UDP-glucuronosyltransferase 1-2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122844500  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122844520  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
122844659  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122844675  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
122844679  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
122819230  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122820200  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122820244  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122820248  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122820249  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122839567  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
122839568  UDP-glucuronosyltransferase-like [KO:K00699] [EC:2.4.1.17]
122828512  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
122828513  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
122828514  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
122828692  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122828693  UDP-glucuronosyltransferase 2A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122828695  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122828696  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
122835323  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
122822693  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
122840734  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
122821729  all-trans-retinol 13,14-reductase-like [KO:K09516] [EC:1.3.99.23]
122821730  all-trans-retinol 13,14-reductase-like [KO:K09516] [EC:1.3.99.23]
122821929  all-trans-retinol 13,14-reductase-like [KO:K09516] [EC:1.3.99.23]
122823112  si:ch1073-13h15.3; inactive all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
122846514  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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