KEGG   PATHWAY: gpo00260
Entry
gpo00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Gordonia polyisoprenivorans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
gpo00260  Glycine, serine and threonine metabolism
gpo00260

Module
gpo_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:gpo00260]
gpo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:gpo00260]
gpo_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:gpo00260]
gpo_M00555  Betaine biosynthesis, choline => betaine [PATH:gpo00260]
gpo_M00621  Glycine cleavage system [PATH:gpo00260]
gpo_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:gpo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Gordonia polyisoprenivorans [GN:gpo]
Gene
GPOL_c06800  ask; aspartokinase Ask [KO:K00928] [EC:2.7.2.4]
GPOL_c06810  asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]
GPOL_c17900  hom; homoserine dehydrogenase Hom [KO:K00003] [EC:1.1.1.3]
GPOL_c17920  thrB; homoserine kinase ThrB [KO:K00872] [EC:2.7.1.39]
GPOL_c17910  thrC; threonine synthase ThrC [KO:K01733] [EC:4.2.3.1]
GPOL_174p00530  threonine aldolase [KO:K01620] [EC:4.1.2.48]
GPOL_c18010  glyA2; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
GPOL_c15480  glyA1; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
GPOL_c28250  glxK; glycerate kinase GlxK [KO:K00865] [EC:2.7.1.165]
GPOL_c10270  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
GPOL_c33920  serA2; D-3-phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GPOL_174p00020  putative phosphoglycerate dehydrogenase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GPOL_c30060  serA1; D-3-phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
GPOL_c39420  serC; phosphoserine aminotransferase SerC [KO:K00831] [EC:2.6.1.52]
GPOL_c30740  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
GPOL_c18690  putative flavin-containing amine oxidase [KO:K00274] [EC:1.4.3.4]
GPOL_c10670  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
GPOL_c04840  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
GPOL_c33260  histamine oxidase [KO:K00276] [EC:1.4.3.21]
GPOL_174p00780  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
GPOL_c28310  gcvT; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
GPOL_c09230  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
GPOL_174p00720  glycine cleavage system H protein [KO:K02437]
GPOL_c08540  putative CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
GPOL_c02820  GMC-family oxidoreductase [KO:K17755] [EC:1.1.3.17]
GPOL_c16540  putative betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
GPOL_c02840  gbsA; betaine aldehyde dehydrogenase GbsA [KO:K00130] [EC:1.2.1.8]
GPOL_c02770  Rieske (2Fe-2S) iron-sulfur domain-containing protein [KO:K00479] [EC:1.14.13.251]
GPOL_c02760  putative ferredoxin oxidoreductase, NAD/FAD-binding protein [KO:K21832] [EC:1.14.13.251]
GPOL_c02700  FAD dependent oxidoreductase precursor [KO:K00309] [EC:1.5.3.10]
GPOL_c33290  soxA3; sarcosine oxidase, alpha subunit SoxA [KO:K00301] [EC:1.5.3.1]
GPOL_c02730  soxA1; sarcosine oxidase, alpha subunit SoxA [KO:K00302] [EC:1.5.3.24 1.5.3.1]
GPOL_c02750  soxB; sarcosine oxidase, beta subunit SoxB [KO:K00303] [EC:1.5.3.24 1.5.3.1]
GPOL_c02720  putative sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
GPOL_c02740  soxD; sarcosine oxidase, delta subunit SoxD [KO:K00304] [EC:1.5.3.24 1.5.3.1]
GPOL_c14990  cysB; cystathionine beta-synthase CysB [KO:K01697] [EC:4.2.1.22]
GPOL_c27490  ilvA2; threonine dehydratase IlvA [KO:K01754] [EC:4.3.1.19]
GPOL_c16370  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
GPOL_c15010  ilvA1; threonine dehydratase IlvA [KO:K01754] [EC:4.3.1.19]
GPOL_c27040  trpA; tryptophan synthase alpha chain TrpA [KO:K01695] [EC:4.2.1.20]
GPOL_c27050  trpB; tryptophan synthase beta chain TrpB [KO:K01696] [EC:4.2.1.20]
GPOL_c49550  tryptophan synthase [KO:K06001] [EC:4.2.1.20]
GPOL_c19660  ectB; diaminobutyrate--2-oxoglutarate transaminase EctB [KO:K00836] [EC:2.6.1.76]
GPOL_c19670  ectA; L-2,4-diaminobutyric acid acetyltransferase EctA [KO:K06718] [EC:2.3.1.178]
GPOL_c19650  ectC; L-ectoine synthase EctC [KO:K06720] [EC:4.2.1.108]
GPOL_c44040  putative hydrolase/peptidase [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
gpo00010  Glycolysis / Gluconeogenesis
gpo00020  Citrate cycle (TCA cycle)
gpo00230  Purine metabolism
gpo00250  Alanine, aspartate and glutamate metabolism
gpo00270  Cysteine and methionine metabolism
gpo00290  Valine, leucine and isoleucine biosynthesis
gpo00300  Lysine biosynthesis
gpo00330  Arginine and proline metabolism
gpo00460  Cyanoamino acid metabolism
gpo00470  D-Amino acid metabolism
gpo00564  Glycerophospholipid metabolism
gpo00600  Sphingolipid metabolism
gpo00620  Pyruvate metabolism
gpo00630  Glyoxylate and dicarboxylate metabolism
gpo00640  Propanoate metabolism
gpo00680  Methane metabolism
gpo00860  Porphyrin metabolism
gpo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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