KEGG   PATHWAY: gvr04142
Entry
gvr04142                    Pathway                                
Name
Lysosome - Galeopterus variegatus (Sunda flying lemur)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
gvr04142  Lysosome
gvr04142

Other DBs
GO: 0005764
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103581247  [KO:K01197] [EC:3.2.1.35]
103581343  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
103581371  [KO:K01197] [EC:3.2.1.35]
103581608  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
103581680  [KO:K01565] [EC:3.10.1.1]
103581997  [KO:K01365] [EC:3.4.22.15]
103582726  [KO:K27947]
103583781  [KO:K01186] [EC:3.2.1.18]
103583922  [KO:K01365] [EC:3.4.22.15]
103585012  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
103585170  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
103585342  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
103585495  SORT1; sortilin [KO:K12388]
103585589  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
103585640  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
103585829  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
103586024  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
103586030  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
103586278  NPC2; epididymal secretory protein E1 [KO:K13443]
103586386  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
103586911  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
103586944  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
103587377  CTNS; cystinosin isoform X1 [KO:K12386]
103587506  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
103587617  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
103587769  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
103587809  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
103587818  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
103588146  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
103588197  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
103588558  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
103588644  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
103588909  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
103588945  HYAL4; LOW QUALITY PROTEIN: hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
103589269  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
103589347  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
103589578  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
103589834  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
103589865  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
103589961  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103590097  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
103590124  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
103590191  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
103590328  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
103590345  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
103590642  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
103590719  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
103590770  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
103590912  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
103591213  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
103591261  SUMF1; sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
103591274  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
103591306  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
103591408  CD68; macrosialin [KO:K06501]
103591795  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
103591911  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
103592093  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
103592354  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
103592474  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
103592526  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
103593098  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
103593365  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
103593500  [KO:K05642]
103593705  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
103593706  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
103593709  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
103594218  CD164; sialomucin core protein 24 [KO:K06546]
103594467  GM2A; ganglioside GM2 activator [KO:K12383]
103594497  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
103594811  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
103594819  CLTA; clathrin light chain A isoform X1 [KO:K04644]
103595123  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
103595227  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
103595231  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
103595316  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
103595456  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
103595478  SLC17A5; sialin isoform X1 [KO:K12301]
103595578  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
103595599  CLN3; battenin isoform X1 [KO:K12389]
103596119  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
103596188  GBA; glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
103596420  DMXL1; dmX-like protein 1 [KO:K24155]
103596585  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
103596736  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
103596858  MCOLN1; mucolipin-1 [KO:K04992]
103597033  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
103597155  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
103597209  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
103597380  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
103597419  CLTB; clathrin light chain B isoform X1 [KO:K04645]
103597479  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
103597707  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
103597755  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
103597991  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
103598560  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
103598571  PSAP; prosaposin isoform X1 [KO:K12382]
103598780  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
103599049  CD63; CD63 antigen [KO:K06497]
103599114  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
103599227  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
103599544  [KO:K12399]
103599597  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
103600306  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
103600399  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
103600446  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
103600563  [KO:K01371] [EC:3.4.22.38]
103600664  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
103600698  [KO:K01195] [EC:3.2.1.31]
103601241  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
103601629  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
103602102  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
103602345  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
103602918  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
103603068  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
103603289  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
103603421  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
103603634  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
103603868  DMXL2; dmX-like protein 2 [KO:K24155]
103604026  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
103604378  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
103604674  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
103604902  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
103605483  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
103605587  [KO:K02154]
103606129  CLTC; clathrin heavy chain 1 [KO:K04646]
103606250  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
103606445  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
103606706  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
103606790  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
103606977  [KO:K04646]
103607572  [KO:K01197] [EC:3.2.1.35]
103607573  [KO:K01197] [EC:3.2.1.35]
103608052  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
103608363  SCARB2; lysosome membrane protein 2 [KO:K12384]
103608389  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
103608951  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
103609164  [KO:K12385]
103609372  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
103610254  [KO:K01197] [EC:3.2.1.35]
103610880  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
103610892  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
gvr00511  Other glycan degradation
gvr00531  Glycosaminoglycan degradation
gvr04130  SNARE interactions in vesicular transport
gvr04140  Autophagy - animal
gvr04144  Endocytosis
KO pathway
ko04142   

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