KEGG   PATHWAY: hsa04740
Entry
hsa04740                    Pathway                                
Name
Olfactory transduction - Homo sapiens (human)
Description
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.
Class
Organismal Systems; Sensory system
Pathway map
hsa04740  Olfactory transduction
hsa04740

Other DBs
GO: 0007608
Organism
Homo sapiens (human) [GN:hsa]
Gene
102723532  [KO:K04257]
105369274  OR4N4C; olfactory receptor family 4 subfamily N member 4C [KO:K04257]
10798  OR5I1; olfactory receptor 5I1 [KO:K04257]
107987545  [KO:K04257]
109  ADCY3; adenylate cyclase type 3 isoform 2 [KO:K08043] [EC:4.6.1.1]
112268384  [KO:K04257]
118568804  OR4M2B; olfactory receptor 4M2 [KO:K04257]
119678  OR52E2; olfactory receptor 52E2 [KO:K04257]
119679  OR52J3; olfactory receptor 52J3 [KO:K04257]
119682  OR51L1; olfactory receptor 51L1 [KO:K04257]
119687  OR51A7; olfactory receptor 51A7 [KO:K04257]
119692  OR51S1; olfactory receptor 51S1 [KO:K04257]
119694  OR51F2; olfactory receptor 51F2 [KO:K04257]
119695  OR52R1; olfactory receptor 52R1 [KO:K04257]
119749  OR4C46; olfactory receptor 4C46 [KO:K04257]
119764  OR4X2; olfactory receptor 4X2 [KO:K04257]
119765  OR4B1; olfactory receptor 4B1 [KO:K04257]
119772  OR52M1; olfactory receptor 52M1 [KO:K04257]
119774  OR52K2; olfactory receptor 52K2 [KO:K04257]
120065  OR5P2; olfactory receptor 5P2 [KO:K04257]
120066  OR5P3; olfactory receptor 5P3 [KO:K04257]
120586  OR8I2; olfactory receptor 8I2 [KO:K04257]
120775  OR2D3; olfactory receptor 2D3 [KO:K04257]
120776  OR2D2; olfactory receptor 2D2 [KO:K04257]
120787  OR52W1; olfactory receptor 52W1 [KO:K04257]
120793  OR56A4; olfactory receptor 56A4 [KO:K04257]
120796  OR56A1; olfactory receptor 56A1 [KO:K04257]
121129  OR2AP1; olfactory receptor 2AP1 [KO:K04257]
121130  OR10P1; olfactory receptor 10P1 [KO:K04257]
121275  OR10AD1; olfactory receptor 10AD1 [KO:K04257]
121364  OR10A7; olfactory receptor 10A7 [KO:K04257]
122740  OR4K14; olfactory receptor 4K14 [KO:K04257]
122742  OR4L1; olfactory receptor 4L1 [KO:K04257]
122748  OR11H6; olfactory receptor 11H6 [KO:K04257]
123041  SLC24A4; sodium/potassium/calcium exchanger 4 isoform 1 precursor [KO:K13752]
124538  OR4D2; olfactory receptor 4D2 [KO:K04257]
1258  CNGB1; cyclic nucleotide-gated channel beta-1 isoform a [KO:K04952]
125958  OR7D4; olfactory receptor 7D4 [KO:K04257]
125962  OR7G1; olfactory receptor 7G1 [KO:K04257]
125963  OR1M1; olfactory receptor 1M1 [KO:K04257]
1260  CNGA2; cyclic nucleotide-gated channel alpha-2 [KO:K04949]
1261  CNGA3; cyclic nucleotide-gated channel alpha-3 isoform 1 [KO:K04950]
1262  CNGA4; cyclic nucleotide-gated channel alpha-4 [KO:K04951]
126370  OR1I1; olfactory receptor 1I1 [KO:K04257]
126541  OR10H4; olfactory receptor 10H4 [KO:K04257]
127059  OR2M5; olfactory receptor 2M5 [KO:K04257]
127062  OR2M3; olfactory receptor 2M3 [KO:K04257]
127064  OR2T12; olfactory receptor 2T12 isoform 1 [KO:K04257]
127066  OR14C36; olfactory receptor 14C36 [KO:K04257]
127068  OR2T34; olfactory receptor 2T34 [KO:K04257]
127069  OR2T10; olfactory receptor 2T10 [KO:K04257]
127074  OR2T4; olfactory receptor 2T4 [KO:K04257]
127077  OR2T11; olfactory receptor 2T11 [KO:K04257]
127385  OR10J5; olfactory receptor 10J5 [KO:K04257]
127608  OR2AJ1; olfactory receptor 2AJ1 [KO:K04257]
127623  OR2B11; olfactory receptor 2B11 [KO:K04257]
128360  OR10T2; olfactory receptor 10T2 [KO:K04257]
128366  OR6P1; olfactory receptor 6P1 [KO:K04257]
128367  OR10X1; olfactory receptor 10X1 [KO:K04257]
128368  OR10Z1; olfactory receptor 10Z1 [KO:K04257]
128371  OR6K6; olfactory receptor 6K6 [KO:K04257]
128372  OR6N1; olfactory receptor 6N1 [KO:K04257]
130075  OR9A4; olfactory receptor 9A4 [KO:K04257]
134083  OR2Y1; olfactory receptor 2Y1 [KO:K04257]
135924  OR9A2; olfactory receptor 9A2 [KO:K04257]
135941  OR2A14; olfactory receptor 2A14 [KO:K04257]
135946  OR6B1; olfactory receptor 6B1 [KO:K04257]
135948  OR2F2; olfactory receptor 2F2 [KO:K04257]
138799  OR13C5; olfactory receptor 13C5 [KO:K04257]
138802  OR13C8; olfactory receptor 13C8 [KO:K04257]
138803  OR13C3; olfactory receptor 13C3 [KO:K04257]
138804  OR13C4; olfactory receptor 13C4 [KO:K04257]
138805  OR13F1; olfactory receptor 13F1 [KO:K04257]
138881  OR1L8; olfactory receptor 1L8 [KO:K04257]
138882  OR1N2; olfactory receptor 1N2 [KO:K04257]
138883  OR1N1; olfactory receptor 1N1 [KO:K04257]
143496  OR52B4; olfactory receptor 52B4 [KO:K04257]
143502  OR52I2; olfactory receptor 52I2 [KO:K04257]
143503  OR51E1; olfactory receptor 51E1 [KO:K04257]
144124  OR10A5; olfactory receptor 10A5 [KO:K04257]
144125  OR2AG1; olfactory receptor 2AG1 [KO:K04257]
150681  OR6B3; olfactory receptor 6B3 [KO:K04257]
156  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
157  GRK3; G protein-coupled receptor kinase 3 isoform 1 [KO:K00910] [EC:2.7.11.15]
158131  OR1Q1; olfactory receptor 1Q1 [KO:K04257]
162998  OR7D2; olfactory receptor 7D2 [KO:K04257]
163688  CALML6; calmodulin-like protein 6 isoform 1 [KO:K02183]
196335  OR56B4; olfactory receptor 56B4 [KO:K04257]
219417  OR8U1; olfactory receptor 8U1 [KO:K04257]
219428  OR4C16; olfactory receptor 4C16 [KO:K04257]
219429  OR4C11; olfactory receptor 4C11 [KO:K04257]
219431  OR4S2; olfactory receptor 4S2 [KO:K04257]
219432  OR4C6; olfactory receptor 4C6 [KO:K04257]
219436  OR5D14; olfactory receptor 5D14 [KO:K04257]
219437  OR5L1; olfactory receptor 5L1 [KO:K04257]
219438  OR5D18; olfactory receptor 5D18 [KO:K04257]
219447  OR5AS1; olfactory receptor 5AS1 [KO:K04257]
219453  OR8K5; olfactory receptor 8K5 [KO:K04257]
219464  OR5T2; olfactory receptor 5T2 [KO:K04257]
219469  OR8H1; olfactory receptor 8H1 [KO:K04257]
219473  OR8K3; olfactory receptor 8K3 [KO:K04257]
219477  OR8J1; olfactory receptor 8J1 [KO:K04257]
219479  OR8U3; olfactory receptor 8U3 [KO:K04257]
219482  OR5M3; olfactory receptor 5M3 [KO:K04257]
219484  OR5M8; olfactory receptor 5M8 [KO:K04257]
219487  OR5M11; olfactory receptor 5M11 [KO:K04257]
219493  OR5AR1; olfactory receptor 5AR1 [KO:K04257]
219858  OR8B12; olfactory receptor 8B12 [KO:K04257]
219865  OR8G5; olfactory receptor 8G5 [KO:K04257]
219869  OR10G8; olfactory receptor 10G8 [KO:K04257]
219870  OR10G9; olfactory receptor 10G9 [KO:K04257]
219873  OR10S1; olfactory receptor 10S1 [KO:K04257]
219874  OR6T1; olfactory receptor 6T1 [KO:K04257]
219875  OR4D5; olfactory receptor 4D5 [KO:K04257]
219952  OR6Q1; olfactory receptor 6Q1 [KO:K04257]
219954  OR9I1; olfactory receptor 9I1 [KO:K04257]
219956  OR9Q1; olfactory receptor 9Q1 [KO:K04257]
219957  OR9Q2; olfactory receptor 9Q2 [KO:K04257]
219958  OR1S2; olfactory receptor 1S2 [KO:K04257]
219959  OR1S1; olfactory receptor 1S1 [KO:K04257]
219960  OR10Q1; olfactory receptor 10Q1 [KO:K04257]
219965  OR5B17; olfactory receptor 5B17 [KO:K04257]
219968  OR5B21; olfactory receptor 5B21 [KO:K04257]
219981  OR5A2; olfactory receptor 5A2 [KO:K04257]
219982  OR5A1; olfactory receptor 5A1 [KO:K04257]
219983  OR4D6; olfactory receptor 4D6 [KO:K04257]
219986  OR4D11; olfactory receptor 4D11 [KO:K04257]
23538  OR52A1; olfactory receptor 52A1 [KO:K04257]
254783  OR6C74; olfactory receptor 6C74 [KO:K04257]
254786  OR6C3; olfactory receptor 6C3 isoform 1 [KO:K04257]
254879  OR2T6; olfactory receptor 2T6 [KO:K04257]
254973  OR1L4; olfactory receptor 1L4 [KO:K04257]
255725  OR52B2; olfactory receptor 52B2 [KO:K04257]
256144  OR4C3; olfactory receptor 4C3 [KO:K04257]
256148  OR4S1; olfactory receptor 4S1 [KO:K04257]
256892  OR51F1; olfactory receptor 51F1 [KO:K04257]
26188  OR1C1; olfactory receptor 1C1 [KO:K04257]
26189  OR1A2; olfactory receptor 1A2 [KO:K04257]
26211  OR2F1; olfactory receptor 2F1 [KO:K04257]
26212  OR2B6; olfactory receptor 2B6 [KO:K04257]
26219  OR1J4; olfactory receptor 1J4 [KO:K04257]
26245  OR2M4; olfactory receptor 2M4 [KO:K04257]
26246  OR2L2; olfactory receptor 2L2 isoform 1 [KO:K04257]
26248  OR2K2; olfactory receptor 2K2 [KO:K04257]
26333  OR7A17; olfactory receptor 7A17 [KO:K04257]
26338  OR5L2; olfactory receptor 5L2 [KO:K04257]
26339  OR5K1; olfactory receptor 5K1 [KO:K04257]
26341  OR5H1; olfactory receptor 5H1 [KO:K04257]
26476  OR10J1; olfactory receptor 10J1 [KO:K04257]
26493  OR8B8; olfactory receptor 8B8 [KO:K04257]
26494  OR8G1; olfactory receptor 8G1 [KO:K04257]
26496  OR10A3; olfactory receptor 10A3 [KO:K04257]
26497  OR10D3; olfactory receptor 10D3 [KO:K04257]
26529  OR12D2; olfactory receptor 12D2 [KO:K04257]
26530  OR12D1; olfactory receptor 12D1 [KO:K04257]
26531  OR11A1; olfactory receptor 11A1 [KO:K04257]
26532  OR10H3; olfactory receptor 10H3 [KO:K04257]
26533  OR10G3; olfactory receptor 10G3 [KO:K04257]
26534  OR10G2; olfactory receptor 10G2 [KO:K04257]
26538  OR10H2; olfactory receptor 10H2 [KO:K04257]
26539  OR10H1; olfactory receptor 10H1 [KO:K04257]
26595  OR8B2; olfactory receptor 8B2 [KO:K04257]
26648  OR7E24; olfactory receptor 7E24 isoform 1 [KO:K04257]
26658  OR7C2; olfactory receptor 7C2 [KO:K04257]
26659  OR7A5; olfactory receptor 7A5 [KO:K04257]
26664  OR7C1; olfactory receptor 7C1 [KO:K04257]
26683  OR4F3; olfactory receptor 4F3/4F16/4F29 [KO:K04257]
26686  OR4E2; olfactory receptor 4E2 [KO:K04257]
26687  OR4E1; olfactory receptor 4E1 [KO:K04257]
26689  OR4D1; olfactory receptor 4D1 [KO:K04257]
26692  OR2W1; olfactory receptor 2W1 [KO:K04257]
26693  OR2V1; olfactory receptor 2V1 [KO:K04257]
26696  OR2T1; olfactory receptor 2T1 [KO:K04257]
26707  OR2J2; olfactory receptor 2J2 [KO:K04257]
26716  OR2H1; olfactory receptor 2H1 [KO:K04257]
26735  OR1L3; olfactory receptor 1L3 [KO:K04257]
26737  OR1L1; olfactory receptor 1L1 [KO:K04257]
26740  OR1J2; olfactory receptor 1J2 [KO:K04257]
2774  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform 2 [KO:K04633]
2782  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1 [KO:K04536]
2788  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
282763  OR51B5; olfactory receptor 51B5 [KO:K04257]
282770  OR10AG1; olfactory receptor 10AG1 [KO:K04257]
282775  OR5J2; olfactory receptor 5J2 [KO:K04257]
283092  OR4C13; olfactory receptor 4C13 [KO:K04257]
283093  OR4C12; olfactory receptor 4C12 [KO:K04257]
283111  OR51V1; olfactory receptor 51V1 [KO:K04257]
283159  OR8D1; olfactory receptor 8D1 [KO:K04257]
283160  OR8D2; olfactory receptor 8D2 [KO:K04257]
283162  OR8B4; olfactory receptor 8B4 [KO:K04257]
283189  OR9G4; olfactory receptor 9G4 isoform 1 [KO:K04257]
283297  OR10A4; olfactory receptor 10A4 [KO:K04257]
283365  OR6C6; olfactory receptor 6C6 [KO:K04257]
283617  OR4K3; olfactory receptor family 4 subfamily K member 3 (gene/pseudogene) [KO:K04257]
283694  OR4N4; olfactory receptor 4N4 [KO:K04257]
284383  OR2Z1; olfactory receptor 2Z1 [KO:K04257]
284433  OR10H5; olfactory receptor 10H5 [KO:K04257]
284521  OR2L13; olfactory receptor 2L13 [KO:K04257]
284532  OR14A16; olfactory receptor 14A16 [KO:K04257]
285659  OR2V2; olfactory receptor 2V2 [KO:K04257]
286362  OR13C9; olfactory receptor 13C9 [KO:K04257]
286365  OR13D1; olfactory receptor 13D1 [KO:K04257]
3000  GUCY2D; retinal guanylyl cyclase 1 precursor [KO:K12321] [EC:4.6.1.2]
338662  OR8D4; olfactory receptor 8D4 [KO:K04257]
338674  OR5F1; olfactory receptor 5F1 [KO:K04257]
338675  OR5AP2; olfactory receptor 5AP2 [KO:K04257]
338751  OR52L1; olfactory receptor 52L1 [KO:K04257]
338755  OR2AG2; olfactory receptor 2AG2 [KO:K04257]
340980  OR52B6; olfactory receptor 52B6 [KO:K04257]
341152  OR2AT4; olfactory receptor 2AT4 isoform 1 [KO:K04257]
341276  OR10A2; olfactory receptor 10A2 [KO:K04257]
341416  OR6C2; olfactory receptor 6C2 [KO:K04257]
341418  OR6C4; olfactory receptor 6C4 [KO:K04257]
341568  OR8S1; olfactory receptor 8S1 [KO:K04257]
341799  OR6S1; olfactory receptor 6S1 [KO:K04257]
343169  OR6F1; olfactory receptor 6F1 [KO:K04257]
343170  OR14K1; olfactory receptor 14K1 [KO:K04257]
343171  OR2W3; olfactory receptor 2W3 [KO:K04257]
343172  OR2T8; olfactory receptor 2T8 [KO:K04257]
343173  OR2T3; olfactory receptor 2T3 [KO:K04257]
343406  OR10R2; olfactory receptor 10R2 isoform 1 [KO:K04257]
343563  OR2T29; olfactory receptor 2T29 [KO:K04257]
346517  OR6V1; olfactory receptor 6V1 [KO:K04257]
346525  OR2A12; olfactory receptor 2A12 [KO:K04257]
346528  OR2A1; olfactory receptor 2A1/2A42 [KO:K04257]
347168  OR1J1; olfactory receptor 1J1 [KO:K04257]
347169  OR1B1; olfactory receptor 1B1 [KO:K04257]
347468  OR13H1; olfactory receptor 13H1 [KO:K04257]
387748  OR56B1; olfactory receptor 56B1 [KO:K04257]
387815  OR8G3; olfactory receptor family 8 subfamily G member 3 (gene/pseudogene) [KO:K04257]
388761  OR14A2; olfactory receptor 14A2 [KO:K04257]
389090  OR6B2; olfactory receptor 6B2 [KO:K04257]
390036  OR52K1; olfactory receptor 52K1 isoform 1 [KO:K04257]
390037  OR52I1; olfactory receptor 52I1 [KO:K04257]
390038  OR51D1; olfactory receptor 51D1 [KO:K04257]
390054  OR52A5; olfactory receptor 52A5 [KO:K04257]
390058  OR51B6; olfactory receptor 51B6 [KO:K04257]
390059  OR51M1; olfactory receptor 51M1 [KO:K04257]
390061  OR51Q1; olfactory receptor 51Q1 [KO:K04257]
390063  OR51I1; olfactory receptor 51I1 [KO:K04257]
390064  OR51I2; olfactory receptor 51I2 [KO:K04257]
390066  OR52D1; olfactory receptor 52D1 [KO:K04257]
390067  OR52H1; olfactory receptor 52H1 [KO:K04257]
390072  OR52N4; olfactory receptor 52N4 [KO:K04257]
390073  OR56B2; olfactory receptor 56B2 [KO:K04257]
390075  OR52N5; olfactory receptor 52N5 [KO:K04257]
390077  OR52N2; olfactory receptor 52N2 [KO:K04257]
390078  OR52E6; olfactory receptor 52E6 [KO:K04257]
390079  OR52E8; olfactory receptor 52E8 [KO:K04257]
390081  OR52E4; olfactory receptor 52E4 [KO:K04257]
390082  OR52E5; olfactory receptor 52E5 [KO:K04257]
390083  OR56A3; olfactory receptor 56A3 [KO:K04257]
390084  OR56A5; olfactory receptor 56A5 [KO:K04257]
390093  OR10A6; olfactory receptor 10A6 isoform 1 [KO:K04257]
390113  OR4X1; olfactory receptor 4X1 [KO:K04257]
390142  OR5D13; olfactory receptor 5D13 [KO:K04257]
390144  OR5D16; olfactory receptor 5D16 [KO:K04257]
390148  OR5W2; olfactory receptor 5W2 [KO:K04257]
390151  OR8H2; olfactory receptor 8H2 [KO:K04257]
390152  OR8H3; olfactory receptor 8H3 [KO:K04257]
390154  OR5T3; olfactory receptor 5T3 [KO:K04257]
390155  OR5T1; olfactory receptor 5T1 [KO:K04257]
390157  OR8K1; olfactory receptor 8K1 [KO:K04257]
390162  OR5M9; olfactory receptor 5M9 [KO:K04257]
390167  OR5M10; olfactory receptor 5M10 [KO:K04257]
390168  OR5M1; olfactory receptor 5M1 [KO:K04257]
390174  OR9G1; olfactory receptor 9G1 [KO:K04257]
390181  OR5AK2; olfactory receptor 5AK2 [KO:K04257]
390190  OR5B2; olfactory receptor 5B2 [KO:K04257]
390191  OR5B12; olfactory receptor 5B12 [KO:K04257]
390195  OR5AN1; olfactory receptor 5AN1 [KO:K04257]
390197  OR4D10; olfactory receptor 4D10 [KO:K04257]
390199  OR4D9; olfactory receptor 4D9 [KO:K04257]
390201  OR10V1; olfactory receptor 10V1 [KO:K04257]
390260  OR6X1; olfactory receptor 6X1 [KO:K04257]
390261  OR6M1; olfactory receptor 6M1 [KO:K04257]
390264  OR10G4; olfactory receptor 10G4 [KO:K04257]
390265  OR10G7; olfactory receptor 10G7 [KO:K04257]
390271  OR8B3; olfactory receptor 8B3 [KO:K04257]
390275  OR8A1; olfactory receptor 8A1 [KO:K04257]
390313  OR5BS1; olfactory receptor 5BS1 [KO:K04257]
390321  OR6C1; olfactory receptor 6C1 [KO:K04257]
390323  OR6C75; olfactory receptor 6C75 [KO:K04257]
390326  OR6C76; olfactory receptor 6C76 isoform 1 [KO:K04257]
390327  OR6C70; olfactory receptor 6C70 [KO:K04257]
390429  OR4N2; olfactory receptor 4N2 [KO:K04257]
390431  OR4K2; olfactory receptor 4K2 [KO:K04257]
390432  OR4Q2; olfactory receptor 4Q2 [KO:K04257]
390433  OR4K13; olfactory receptor 4K13 [KO:K04257]
390436  OR4K17; olfactory receptor 4K17 [KO:K04257]
390437  OR4N5; olfactory receptor 4N5 [KO:K04257]
390439  OR11G2; olfactory receptor 11G2 [KO:K04257]
390441  OR11H7; olfactory receptor 11H7 [KO:K04257]
390442  OR11H4; olfactory receptor 11H4 [KO:K04257]
390445  OR5AU1; olfactory receptor 5AU1 [KO:K04257]
390538  OR4M2; olfactory receptor 4M2 [KO:K04257]
390648  OR4F6; olfactory receptor 4F6 [KO:K04257]
390649  OR4F15; olfactory receptor 4F15 [KO:K04257]
390882  OR7G2; olfactory receptor 7G2 [KO:K04257]
390883  OR7G3; olfactory receptor 7G3 [KO:K04257]
390892  OR7A10; olfactory receptor 7A10 [KO:K04257]
391107  OR10K2; olfactory receptor 10K2 [KO:K04257]
391109  OR10K1; olfactory receptor 10K1 [KO:K04257]
391112  OR6Y1; olfactory receptor 6Y1 [KO:K04257]
391114  OR6K3; olfactory receptor 6K3 [KO:K04257]
391121  OR10J4; olfactory receptor 10J4 [KO:K04257]
391189  OR11L1; olfactory receptor 11L1 [KO:K04257]
391190  OR2L8; olfactory receptor 2L8 [KO:K04257]
391191  OR2AK2; olfactory receptor 2AK2 [KO:K04257]
391192  OR2L3; olfactory receptor 2L3 [KO:K04257]
391194  OR2M2; olfactory receptor 2M2 [KO:K04257]
391195  OR2T33; olfactory receptor 2T33 [KO:K04257]
391196  OR2M7; olfactory receptor 2M7 [KO:K04257]
391211  OR2G6; olfactory receptor 2G6 [KO:K04257]
392133  OR10AC1; olfactory receptor family 10 subfamily AC member 1 (gene/pseudogene) [KO:K04257]
392138  OR2A25; olfactory receptor 2A25 [KO:K04257]
392309  OR13J1; olfactory receptor 13J1 [KO:K04257]
392376  OR13C2; olfactory receptor 13C2 [KO:K04257]
392390  OR1L6; olfactory receptor 1L6 [KO:K04257]
392391  OR5C1; olfactory receptor 5C1 [KO:K04257]
392392  OR1K1; olfactory receptor 1K1 [KO:K04257]
393046  OR2A5; olfactory receptor 2A5 [KO:K04257]
401427  OR2A7; olfactory receptor 2A7 [KO:K04257]
401661  OR51C1; olfactory receptor OR51C1 [KO:K04257]
401665  OR51T1; olfactory receptor 51T1 [KO:K04257]
401666  OR51A4; olfactory receptor 51A4 [KO:K04257]
401667  OR51A2; olfactory receptor 51A2 [KO:K04257]
401992  OR2T2; olfactory receptor 2T2 [KO:K04257]
401993  OR2T5; olfactory receptor 2T5 [KO:K04257]
401994  OR14I1; olfactory receptor 14I1 [KO:K04257]
402135  OR5K2; olfactory receptor 5K2 [KO:K04257]
402317  OR2A42; olfactory receptor 2A1/2A42 [KO:K04257]
403239  OR2T27; olfactory receptor 2T27 [KO:K04257]
403244  OR2T35; olfactory receptor 2T35 [KO:K04257]
403253  OR4A47; olfactory receptor 4A47 [KO:K04257]
403257  OR4C45; olfactory receptor 4C45 [KO:K04257]
403273  OR5H14; olfactory receptor 5H14 [KO:K04257]
403274  OR5H15; olfactory receptor 5H15 [KO:K04257]
403277  OR5K3; olfactory receptor 5K3 [KO:K04257]
403278  OR5K4; olfactory receptor 5K4 [KO:K04257]
403282  OR6C65; olfactory receptor 6C65 [KO:K04257]
403284  OR6C68; olfactory receptor 6C68 [KO:K04257]
408  ARRB1; beta-arrestin-1 isoform A [KO:K04439]
409  ARRB2; beta-arrestin-2 isoform 1 [KO:K04439]
440153  OR11H12; olfactory receptor 11H12 [KO:K04257]
441308  OR4F21; olfactory receptor 4F21 [KO:K04257]
441608  OR5B3; olfactory receptor 5B3 [KO:K04257]
441639  OR9K2; olfactory receptor 9K2 [KO:K04257]
441669  OR4Q3; olfactory receptor 4Q3 isoform 1 [KO:K04257]
441670  OR4M1; olfactory receptor 4M1 [KO:K04257]
441933  OR13G1; olfactory receptor 13G1 [KO:K04257]
442184  OR2B3; putative olfactory receptor 2B3 [KO:K04257]
442185  OR2J1; olfactory receptor 2J1 [KO:K04257]
442186  OR2J3; olfactory receptor 2J3 [KO:K04257]
442191  OR14J1; olfactory receptor 14J1 [KO:K04257]
442194  OR10C1; olfactory receptor 10C1 [KO:K04257]
442361  OR2A2; olfactory receptor 2A2 [KO:K04257]
4991  OR1D2; olfactory receptor 1D2 [KO:K04257]
4992  OR1F1; olfactory receptor 1F1 isoform 1 [KO:K04257]
4993  OR2C1; olfactory receptor 2C1 [KO:K04257]
4994  OR3A1; olfactory receptor 3A1 [KO:K04257]
4995  OR3A2; olfactory receptor 3A2 [KO:K04257]
504189  OR8U8; olfactory receptor 8U8 [KO:K04257]
504190  OR8U9; olfactory receptor 8U9 [KO:K04257]
504191  OR9G9; olfactory receptor 9G9 [KO:K04257]
5136  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2 [KO:K13755] [EC:3.1.4.17]
5137  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2 [KO:K13755] [EC:3.1.4.17]
5138  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 [KO:K18283] [EC:3.1.4.17]
5153  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1 [KO:K13755] [EC:3.1.4.17]
51764  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
51806  CALML5; calmodulin-like protein 5 [KO:K02183]
5566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
5592  PRKG1; cGMP-dependent protein kinase 1 isoform 1 [KO:K07376] [EC:2.7.11.12]
5593  PRKG2; cGMP-dependent protein kinase 2 isoform a [KO:K19477] [EC:2.7.11.12]
56656  OR2S2; olfactory receptor 2S2 [KO:K04257]
57101  ANO2; anoctamin-2 isoform 3 [KO:K19497]
5997  RGS2; regulator of G-protein signaling 2 [KO:K18154]
653166  OR1D4; olfactory receptor family 1 subfamily D member 4 [KO:K04257]
6543  SLC8A2; sodium/calcium exchanger 2 precursor [KO:K05849]
6546  SLC8A1; sodium/calcium exchanger 1 isoform A precursor [KO:K05849]
6547  SLC8A3; sodium/calcium exchanger 3 isoform C precursor [KO:K05849]
65944  OR2B8; olfactory receptor family 2 subfamily B member 8 (gene/pseudogene) [KO:K04257]
729759  OR4F29; olfactory receptor 4F3/4F16/4F29 [KO:K04257]
79290  OR13A1; olfactory receptor 13A1 [KO:K04257]
79295  OR5H6; olfactory receptor 5H6 [KO:K04257]
79296  OR52E1; olfactory receptor 52E1 [KO:K04257]
79310  OR5H2; olfactory receptor 5H2 [KO:K04257]
79317  OR4K5; olfactory receptor 4K5 [KO:K04257]
7932  OR2H2; olfactory receptor 2H2 [KO:K04257]
79324  OR51G1; olfactory receptor 51G1 [KO:K04257]
79334  OR11H2; olfactory receptor 11H2 [KO:K04257]
79339  OR51B4; olfactory receptor 51B4 [KO:K04257]
79345  OR51B2; olfactory receptor 51B2 [KO:K04257]
79346  OR4C5; olfactory receptor 4C5 [KO:K04257]
79473  OR52N1; olfactory receptor 52N1 [KO:K04257]
79482  OR5AL1; olfactory receptor 5AL1 [KO:K04257]
79490  OR10G6; olfactory receptor 10G6 [KO:K04257]
79501  OR4F5; olfactory receptor 4F5 [KO:K04257]
79541  OR2A4; olfactory receptor 2A4 [KO:K04257]
79544  OR4K1; olfactory receptor 4K1 [KO:K04257]
79549  OR6J1; olfactory receptor 6J1 [KO:K04257]
801  CALM1; calmodulin-1 isoform 2 [KO:K02183]
805  CALM2; calmodulin-2 isoform 2 [KO:K02183]
808  CALM3; calmodulin-3 isoform 1 [KO:K02183]
810  CALML3; calmodulin-like protein 3 [KO:K02183]
81050  OR5AC2; olfactory receptor 5AC2 [KO:K04257]
81061  OR11H1; olfactory receptor 11H1 [KO:K04257]
81099  OR4F17; olfactory receptor 4F17 isoform 1 [KO:K04257]
81127  OR4K15; olfactory receptor 4K15 [KO:K04257]
81168  OR8J3; olfactory receptor 8J3 [KO:K04257]
81169  OR8J2; olfactory receptor family 8 subfamily J member 2 (gene/pseudogene) [KO:K04257]
81248  OR52P1; olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) [KO:K04257]
81282  OR51G2; olfactory receptor 51G2 [KO:K04257]
81285  OR51E2; olfactory receptor 51E2 [KO:K04257]
81300  OR4P4; olfactory receptor 4P4 isoform 1 [KO:K04257]
81309  OR4C15; olfactory receptor 4C15 [KO:K04257]
81318  OR4A5; olfactory receptor 4A5 [KO:K04257]
81327  OR4A16; olfactory receptor 4A16 [KO:K04257]
81328  OR4A15; olfactory receptor 4A15 [KO:K04257]
81341  OR10W1; olfactory receptor 10W1 [KO:K04257]
81392  OR2AE1; olfactory receptor 2AE1 [KO:K04257]
81399  OR4F16; olfactory receptor 4F3/4F16/4F29 [KO:K04257]
81439  OR9H1; olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) [KO:K04257]
81442  OR6N2; olfactory receptor 6N2 [KO:K04257]
81448  OR6K2; olfactory receptor 6K2 [KO:K04257]
81466  OR2L5; olfactory receptor 2L5 [KO:K04257]
81469  OR2G3; olfactory receptor 2G3 [KO:K04257]
81470  OR2G2; olfactory receptor 2G2 [KO:K04257]
81472  OR2C3; olfactory receptor 2C3 [KO:K04257]
815  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17]
816  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1 [KO:K04515] [EC:2.7.11.17]
81696  OR5V1; olfactory receptor 5V1 [KO:K04257]
81697  OR2B2; olfactory receptor 2B2 [KO:K04257]
817  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3 [KO:K04515] [EC:2.7.11.17]
81797  OR12D3; olfactory receptor 12D3 [KO:K04257]
818  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7 [KO:K04515] [EC:2.7.11.17]
8383  OR1A1; olfactory receptor 1A1 [KO:K04257]
8386  OR1D5; olfactory receptor 1D5 [KO:K04257]
8387  OR1E1; olfactory receptor 1E1 [KO:K04257]
8388  OR1E2; olfactory receptor 1E2 [KO:K04257]
8390  OR1G1; olfactory receptor 1G1 [KO:K04257]
8392  OR3A3; olfactory receptor 3A3 [KO:K04257]
83988  NCALD; neurocalcin-delta [KO:K19695]
8590  OR6A2; olfactory receptor 6A2 [KO:K04257]
8594  OR5D3; olfactory receptor OR5D3 [KO:K04257]
91860  CALML4; calmodulin-like protein 4 isoform 1 [KO:K02183]
9596  OR1R1; olfactory receptor OR1R1 [KO:K04257]
Compound
C00020  AMP
C00076  Calcium cation
C00144  GMP
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
Reference
PMID:20145624
  Authors
Kaupp UB
  Title
Olfactory signalling in vertebrates and insects: differences and commonalities.
  Journal
Nat Rev Neurosci 11:188-200 (2010)
DOI:10.1038/nrn2789
Reference
PMID:24733839
  Authors
Peterlin Z, Firestein S, Rogers ME
  Title
The state of the art of odorant receptor deorphanization: a report from the orphanage.
  Journal
J Gen Physiol 143:527-42 (2014)
DOI:10.1085/jgp.201311151
Reference
PMID:19652915
  Authors
Kato A, Touhara K
  Title
Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization.
  Journal
Cell Mol Life Sci 66:3743-53 (2009)
DOI:10.1007/s00018-009-0111-6
Reference
PMID:11557990
  Authors
Firestein S.
  Title
How the olfactory system makes sense of scents.
  Journal
Nature 413:211-8 (2001)
DOI:10.1038/35093026
Reference
PMID:16269360
  Authors
Ache BW, Young JM.
  Title
Olfaction: diverse species, conserved principles.
  Journal
Neuron 48:417-30 (2005)
DOI:10.1016/j.neuron.2005.10.022
Reference
PMID:10944513
  Authors
Zufall F, Leinders-Zufall T.
  Title
The cellular and molecular basis of odor adaptation.
  Journal
Chem Senses 25:473-81 (2000)
DOI:10.1093/chemse/25.4.473
Reference
PMID:22875451
  Authors
Lodovichi C, Belluscio L
  Title
Odorant receptors in the formation of the olfactory bulb circuitry.
  Journal
Physiology (Bethesda) 27:200-12 (2012)
DOI:10.1152/physiol.00015.2012
Reference
PMID:12488531
  Authors
Kohout TA, Lefkowitz RJ.
  Title
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
  Journal
Mol Pharmacol 63:9-18 (2003)
DOI:10.1124/mol.63.1.9
Reference
PMID:22735517
  Authors
De Palo G, Boccaccio A, Miri A, Menini A, Altafini C
  Title
A dynamical feedback model for adaptation in the olfactory transduction pathway.
  Journal
Biophys J 102:2677-86 (2012)
DOI:10.1016/j.bpj.2012.04.040
Reference
PMID:19941039
  Authors
Zufall F, Munger SD
  Title
Receptor guanylyl cyclases in mammalian olfactory function.
  Journal
Mol Cell Biochem 334:191-7 (2010)
DOI:10.1007/s11010-009-0325-9
Reference
PMID:19306880
  Authors
Duda T, Sharma RK
  Title
Ca2+-modulated ONE-GC odorant signal transduction.
  Journal
FEBS Lett 583:1327-30 (2009)
DOI:10.1016/j.febslet.2009.03.036
Related
pathway
hsa00230  Purine metabolism
hsa04024  cAMP signaling pathway
KO pathway
ko04740   

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