KEGG T01001: 2335

Homo sapiens (human): 2335

Entry

2335              CDS       T01001

Symbol

FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF

Name

(RefSeq) fibronectin 1

K05717

fibronectin 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04512

ECM-receptor interaction

hsa04518

Integrin signaling

hsa04810

Regulation of actin cytoskeleton

hsa04820

Cytoskeleton in muscle cells

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa05100

Bacterial invasion of epithelial cells

hsa05135

Yersinia infection

hsa05146

Amoebiasis

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05222

Small cell lung cancer

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06539  Cytoskeleton in muscle cells
nt06548  Integrin signaling

Element

N00393

ITGA/B-RhoGAP-RhoA signaling pathway

N00951

ITGA/B-RHOG-RAC signaling pathway

N01068

ITGA/B-FAK-RAC signaling pathway

N01070

ITGA/B-FAK-CDC42 signaling pathway

N01072

ITGA/B-RhoGEF-RhoA signaling pathway

N01080

ITGA/B-TALIN/VINCULIN signaling pathway

N01814

Extracellular matrix - Basal lamina

N01921

Integrin alpha4beta1 signaling

N01973

Integrin alpha4beta7 signaling

N01977

Integrin alphaDbeta2 signaling

N01979

Integrin alphaIIbbeta3 signaling

N01980

Integrin alpha5beta1 signaling

N01981

Integrin alpha8beta1 signaling

N01982

Integrin alphaVbeta1 signaling

N01983

Integrin alphaVbeta3 signaling

N01985

Integrin alphaVbeta6 signaling

N01986

Integrin alphaVbeta8 signaling

Disease

H01260

Glomerulopathy with fibronectin deposits

H02185

Spondylometaphyseal dysplasia

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    2335 (FN1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    2335 (FN1)
   04518 Integrin signaling
    2335 (FN1)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2335 (FN1)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    2335 (FN1)
   04810 Regulation of actin cytoskeleton
    2335 (FN1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2335 (FN1)
   05205 Proteoglycans in cancer
    2335 (FN1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    2335 (FN1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    2335 (FN1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    2335 (FN1)
   05100 Bacterial invasion of epithelial cells
    2335 (FN1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    2335 (FN1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    2335 (FN1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2335 (FN1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2335 (FN1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2335 (FN1)
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    2335 (FN1)
Membrane trafficking [BR:hsa04131]
Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    2335 (FN1)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of bladder cancer cells
   2335 (FN1)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   2335 (FN1)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
Fibronectin (FN) domain-containing proteins
  Fibronectin type I domain-containing proteins
   2335 (FN1)

SSDB

Motif

Pfam:

fn3 fn1 FN3_DSCAM-DSCAML_C Pur_ac_phosph_N fn2 Fn3_Dep-1_2nd Fn3_VIN3 Fn3_Dep-1_3rd NDNF FN3_Tor_3rd Ig_RIMBP2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

2:complement(215360865..215436068)

AA seq 2477 aa
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV
GYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAP
PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTP
LRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHS
RNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWD
APAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPA
SSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKT
AGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTNIDRPKGLAFTDVDVDSIK
IAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDM
ESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEIN
LAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETT
ITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDN
ARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVP
RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPE
ILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPI
RHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGLNPNASTGQEALSQTTISWAPFQDT
SEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEVVT
VGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSR
WCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQ
KEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPI
ECFMPLDVQADREDSRE

NT seq 7434 nt +upstreamnt +downstreamnt
atgcttaggggtccggggcccgggctgctgctgctggccgtccagtgcctggggacagcg
gtgccctccacgggagcctcgaagagcaagaggcaggctcagcaaatggttcagccccag
tccccggtggctgtcagtcaaagcaagcccggttgttatgacaatggaaaacactatcag
ataaatcaacagtgggagcggacctacctaggcaatgcgttggtttgtacttgttatgga
ggaagccgaggttttaactgcgagagtaaacctgaagctgaagagacttgctttgacaag
tacactgggaacacttaccgagtgggtgacacttatgagcgtcctaaagactccatgatc
tgggactgtacctgcatcggggctgggcgagggagaataagctgtaccatcgcaaaccgc
tgccatgaagggggtcagtcctacaagattggtgacacctggaggagaccacatgagact
ggtggttacatgttagagtgtgtgtgtcttggtaatggaaaaggagaatggacctgcaag
cccatagctgagaagtgttttgatcatgctgctgggacttcctatgtggtcggagaaacg
tgggagaagccctaccaaggctggatgatggtagattgtacttgcctgggagaaggcagc
ggacgcatcacttgcacttctagaaatagatgcaacgatcaggacacaaggacatcctat
agaattggagacacctggagcaagaaggataatcgaggaaacctgctccagtgcatctgc
acaggcaacggccgaggagagtggaagtgtgagaggcacacctctgtgcagaccacatcg
agcggatctggccccttcaccgatgttcgtgcagctgtttaccaaccgcagcctcacccc
cagcctcctccctatggccactgtgtcacagacagtggtgtggtctactctgtggggatg
cagtggctgaagacacaaggaaataagcaaatgctttgcacgtgcctgggcaacggagtc
agctgccaagagacagctgtaacccagacttacggtggcaactcaaatggagagccatgt
gtcttaccattcacctacaatggcaggacgttctactcctgcaccacagaagggcgacag
gacggacatctttggtgcagcacaacttcgaattatgagcaggaccagaaatactctttc
tgcacagaccacactgttttggttcagactcgaggaggaaattccaatggtgccttgtgc
cacttccccttcctatacaacaaccacaattacactgattgcacttctgagggcagaaga
gacaacatgaagtggtgtgggaccacacagaactatgatgccgaccagaagtttgggttc
tgccccatggctgcccacgaggaaatctgcacaaccaatgaaggggtcatgtaccgcatt
ggagatcagtgggataagcagcatgacatgggtcacatgatgaggtgcacgtgtgttggg
aatggtcgtggggaatggacatgcattgcctactcgcagcttcgagatcagtgcattgtt
gatgacatcacttacaatgtgaacgacacattccacaagcgtcatgaagaggggcacatg
ctgaactgtacatgcttcggtcagggtcggggcaggtggaagtgtgatcccgtcgaccaa
tgccaggattcagagactgggacgttttatcaaattggagattcatgggagaagtatgtg
catggtgtcagataccagtgctactgctatggccgtggcattggggagtggcattgccaa
cctttacagacctatccaagctcaagtggtcctgtcgaagtatttatcactgagactccg
agtcagcccaactcccaccccatccagtggaatgcaccacagccatctcacatttccaag
tacattctcaggtggagacctaaaaattctgtaggccgttggaaggaagctaccatacca
ggccacttaaactcctacaccatcaaaggcctgaagcctggtgtggtatacgagggccag
ctcatcagcatccagcagtacggccaccaagaagtgactcgctttgacttcaccaccacc
agcaccagcacacctgtgaccagcaacaccgtgacaggagagacgactcccttttctcct
cttgtggccacttctgaatctgtgaccgaaatcacagccagtagctttgtggtctcctgg
gtctcagcttccgacaccgtgtcgggattccgggtggaatatgagctgagtgaggaggga
gatgagccacagtacctggatcttccaagcacagccacttctgtgaacatccctgacctg
cttcctggccgaaaatacattgtaaatgtctatcagatatctgaggatggggagcagagt
ttgatcctgtctacttcacaaacaacagcgcctgatgcccctcctgacacgactgtggac
caagttgatgacacctcaattgttgttcgctggagcagaccccaggctcccatcacaggg
tacagaatagtctattcgccatcagtagaaggtagcagcacagaactcaaccttcctgaa
actgcaaactccgtcaccctcagtgacttgcaacctggtgttcagtataacatcactatc
tatgctgtggaagaaaatcaagaaagtacacctgttgtcattcaacaagaaaccactggc
accccacgctcagatacagtgccctctcccagggacctgcagtttgtggaagtgacagac
gtgaaggtcaccatcatgtggacaccgcctgagagtgcagtgaccggctaccgtgtggat
gtgatccccgtcaacctgcctggcgagcacgggcagaggctgcccatcagcaggaacacc
tttgcagaagtcaccgggctgtcccctggggtcacctattacttcaaagtctttgcagtg
agccatgggagggagagcaagcctctgactgctcaacagacaaccaaactggatgctccc
actaacctccagtttgtcaatgaaactgattctactgtcctggtgagatggactccacct
cgggcccagataacaggataccgactgaccgtgggccttacccgaagaggacagcccagg
cagtacaatgtgggtccctctgtctccaagtacccactgaggaatctgcagcctgcatct
gagtacaccgtatccctcgtggccataaagggcaaccaagagagccccaaagccactgga
gtctttaccacactgcagcctgggagctctattccaccttacaacaccgaggtgactgag
accaccattgtgatcacatggacgcctgctccaagaattggttttaagctgggtgtacga
ccaagccagggaggagaggcaccacgagaagtgacttcagactcaggaagcatcgttgtg
tccggcttgactccaggagtagaatacgtctacaccatccaagtcctgagagatggacag
gaaagagatgcgccaattgtaaacaaagtggtgacaccattgtctccaccaacaaacttg
catctggaggcaaaccctgacactggagtgctcacagtctcctgggagaggagcaccacc
ccagacattactggttatagaattaccacaacccctacaaacggccagcagggaaattct
ttggaagaagtggtccatgctgatcagagctcctgcacttttgataacctgagtcccggc
ctggagtacaatgtcagtgtttacactgtcaaggatgacaaggaaagtgtccctatctct
gataccatcatcccagaggtgccccaactcactgacctaagctttgttgatataaccgat
tcaagcatcggcctgaggtggaccccgctaaactcttccaccattattgggtaccgcatc
acagtagttgcggcaggagaaggtatccctatttttgaagattttgtggactcctcagta
ggatactacacagtcacagggctggagccgggcattgactatgatatcagcgttatcact
ctcattaatggcggcgagagtgcccctactacactgacacaacaaacggctgttcctcct
cccactgacctgcgattcaccaacattggtccagacaccatgcgtgtcacctgggctcca
cccccatccattgatttaaccaacttcctggtgcgttactcacctgtgaaaaatgaggaa
gatgttgcagagttgtcaatttctccttcagacaatgcagtggtcttaacaaatctcctg
cctggtacagaatatgtagtgagtgtctccagtgtctacgaacaacatgagagcacacct
cttagaggaagacagaaaacaggtcttgattccccaactggcattgacttttctgatatt
actgccaactcttttactgtgcactggattgctcctcgagccaccatcactggctacagg
atccgccatcatcccgagcacttcagtgggagacctcgagaagatcgggtgccccactct
cggaattccatcaccctcaccaacctcactccaggcacagagtatgtggtcagcatcgtt
gctcttaatggcagagaggaaagtcccttattgattggccaacaatcaacagtttctgat
gttccgagggacctggaagttgttgctgcgacccccaccagcctactgatcagctgggat
gctcctgctgtcacagtgagatattacaggatcacttacggagagacaggaggaaatagc
cctgtccaggagttcactgtgcctgggagcaagtctacagctaccatcagcggccttaaa
cctggagttgattataccatcactgtgtatgctgtcactggccgtggagacagccccgca
agcagcaagccaatttccattaattaccgaacagaaattgacaaaccatcccagatgcaa
gtgaccgatgttcaggacaacagcattagtgtcaagtggctgccttcaagttcccctgtt
actggttacagagtaaccaccactcccaaaaatggaccaggaccaacaaaaactaaaact
gcaggtccagatcaaacagaaatgactattgaaggcttgcagcccacagtggagtatgtg
gttagtgtctatgctcagaatccaagcggagagagtcagcctctggttcagactgcagta
accaacattgatcgccctaaaggactggcattcactgatgtggatgtcgattccatcaaa
attgcttgggaaagcccacaggggcaagtttccaggtacagggtgacctactcgagccct
gaggatggaatccatgagctattccctgcacctgatggtgaagaagacactgcagagctg
caaggcctcagaccgggttctgagtacacagtcagtgtggttgccttgcacgatgatatg
gagagccagcccctgattggaacccagtccacagctattcctgcaccaactgacctgaag
ttcactcaggtcacacccacaagcctgagcgcccagtggacaccacccaatgttcagctc
actggatatcgagtgcgggtgacccccaaggagaagaccggaccaatgaaagaaatcaac
cttgctcctgacagctcatccgtggttgtatcaggacttatggtggccaccaaatatgaa
gtgagtgtctatgctcttaaggacactttgacaagcagaccagctcagggagttgtcacc
actctggagaatgtcagcccaccaagaagggctcgtgtgacagatgctactgagaccacc
atcaccattagctggagaaccaagactgagacgatcactggcttccaagttgatgccgtt
ccagccaatggccagactccaatccagagaaccatcaagccagatgtcagaagctacacc
atcacaggtttacaaccaggcactgactacaagatctacctgtacaccttgaatgacaat
gctcggagctcccctgtggtcatcgacgcctccactgccattgatgcaccatccaacctg
cgtttcctggccaccacacccaattccttgctggtatcatggcagccgccacgtgccagg
attaccggctacatcatcaagtatgagaagcctgggtctcctcccagagaagtggtccct
cggccccgccctggtgtcacagaggctactattactggcctggaaccgggaaccgaatat
acaatttatgtcattgccctgaagaataatcagaagagcgagcccctgattggaaggaaa
aagacagacgagcttccccaactggtaacccttccacaccccaatcttcatggaccagag
atcttggatgttccttccacagttcaaaagacccctttcgtcacccaccctgggtatgac
actggaaatggtattcagcttcctggcacttctggtcagcaacccagtgttgggcaacaa
atgatctttgaggaacatggttttaggcggaccacaccgcccacaacggccacccccata
aggcataggccaagaccatacccgccgaatgtaggtgaggaaatccaaattggtcacatc
cccagggaagatgtagactatcacctgtacccacacggtccgggactcaatccaaatgcc
tctacaggacaagaagctctctctcagacaaccatctcatgggccccattccaggacact
tctgagtacatcatttcatgtcatcctgttggcactgatgaagaacccttacagttcagg
gttcctggaacttctaccagtgccactctgacaggcctcaccagaggtgccacctacaac
gtcatagtggaggcactgaaagaccagcagaggcataaggttcgggaagaggttgttacc
gtgggcaactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgacccc
tacacagtttcccattatgccgttggagatgagtgggaacgaatgtctgaatcaggcttt
aaactgttgtgccagtgcttaggctttggaagtggtcatttcagatgtgattcatctaga
tggtgccatgacaatggtgtgaactacaagattggagagaagtgggaccgtcagggagaa
aatggccagatgatgagctgcacatgtcttgggaacggaaaaggagaattcaagtgtgac
cctcatgaggcaacgtgttatgatgatgggaagacataccacgtaggagaacagtggcag
aaggaatatctcggtgccatttgctcctgcacatgctttggaggccagcggggctggcgc
tgtgacaactgccgcagacctgggggtgaacccagtcccgaaggcactactggccagtcc
tacaaccagtattctcagagataccatcagagaacaaacactaatgttaattgcccaatt
gagtgcttcatgcctttagatgtacaggctgacagagaagattcccgagagtaa

Homo sapiens (human): 7040

Entry

7040              CDS       T01001

Symbol

TGFB1, CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta

Name

(RefSeq) transforming growth factor beta 1

K13375

transforming growth factor beta-1

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04068

FoxO signaling pathway

hsa04110

Cell cycle

hsa04148

Efferocytosis

hsa04218

Cellular senescence

hsa04350

TGF-beta signaling pathway

hsa04380

Osteoclast differentiation

hsa04390

Hippo signaling pathway

hsa04518

Integrin signaling

hsa04659

Th17 cell differentiation

hsa04672

Intestinal immune network for IgA production

hsa04926

Relaxin signaling pathway

hsa04932

Non-alcoholic fatty liver disease

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa05140

Leishmaniasis

hsa05142

Chagas disease

hsa05144

Malaria

hsa05145

Toxoplasmosis

hsa05146

Amoebiasis

hsa05152

Tuberculosis

hsa05161

Hepatitis B

hsa05166

Human T-cell leukemia virus 1 infection

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05210

Colorectal cancer

hsa05211

Renal cell carcinoma

hsa05212

Pancreatic cancer

hsa05220

Chronic myeloid leukemia

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05321

Inflammatory bowel disease

hsa05323

Rheumatoid arthritis

hsa05410

Hypertrophic cardiomyopathy

hsa05414

Dilated cardiomyopathy

hsa05415

Diabetic cardiomyopathy

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06218  TGFB signaling (cancer)
nt06225  HIF-1 signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06276  Chronic myeloid leukemia
nt06507  TGFB signaling
nt06535  Efferocytosis
nt06542  HIF signaling
nt06548  Integrin signaling

Element

N00063

TGF-beta signaling pathway

N00079

HIF-1 signaling pathway

N00080

Loss of VHL to HIF-1 signaling pathway

N00081

Mutation-inactivated VHL to HIF-1 signaling pathway

N00531

HBV HBx to TGF-beta signaling pathway

N01460

Plasmin mediated activation of latent TGF-beta

N01773

PTGS2-PGE2-TGFB1 pathway

N01781

Activation of LXRs by oxysterols

N01980

Integrin alpha5beta1 signaling

N01981

Integrin alpha8beta1 signaling

N01983

Integrin alphaVbeta3 signaling

N01984

Integrin alphaVbeta5 signaling

N01985

Integrin alphaVbeta6 signaling

N01986

Integrin alphaVbeta8 signaling

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00218

Cystic fibrosis

H00434

Camurati-Engelmann disease

H02669

Inflammatory bowel disease, immunodeficiency, and encephalopathy

Drug target

Fresolimumab:

D09620

Linavonkibart:

D12801

Livmoniplimab:

D12793

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7040 (TGFB1)
   04350 TGF-beta signaling pathway
    7040 (TGFB1)
   04390 Hippo signaling pathway
    7040 (TGFB1)
   04068 FoxO signaling pathway
    7040 (TGFB1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7040 (TGFB1)
   04518 Integrin signaling
    7040 (TGFB1)
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    7040 (TGFB1)
  09143 Cell growth and death
   04110 Cell cycle
    7040 (TGFB1)
   04218 Cellular senescence
    7040 (TGFB1)
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    7040 (TGFB1)
   04672 Intestinal immune network for IgA production
    7040 (TGFB1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    7040 (TGFB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7040 (TGFB1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7040 (TGFB1)
   05205 Proteoglycans in cancer
    7040 (TGFB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7040 (TGFB1)
   05212 Pancreatic cancer
    7040 (TGFB1)
   05225 Hepatocellular carcinoma
    7040 (TGFB1)
   05226 Gastric cancer
    7040 (TGFB1)
   05220 Chronic myeloid leukemia
    7040 (TGFB1)
   05211 Renal cell carcinoma
    7040 (TGFB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7040 (TGFB1)
   05161 Hepatitis B
    7040 (TGFB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    7040 (TGFB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7040 (TGFB1)
   05144 Malaria
    7040 (TGFB1)
   05145 Toxoplasmosis
    7040 (TGFB1)
   05140 Leishmaniasis
    7040 (TGFB1)
   05142 Chagas disease
    7040 (TGFB1)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7040 (TGFB1)
   05321 Inflammatory bowel disease
    7040 (TGFB1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7040 (TGFB1)
   05414 Dilated cardiomyopathy
    7040 (TGFB1)
   05415 Diabetic cardiomyopathy
    7040 (TGFB1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    7040 (TGFB1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    7040 (TGFB1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    7040 (TGFB1)
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    7040 (TGFB1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7040 (TGFB1)
Chaperones and folding catalysts [BR:hsa03110]
Intramolecular chaperones
  Others
   7040 (TGFB1)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Transforming growth factors (RSTK binding)
   7040 (TGFB1)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   7040 (TGFB1)

SSDB

Motif

Pfam:

TGFb_propeptide TGF_beta

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

19:complement(41330323..41353922)

AA seq 390 aa
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

NT seq 1173 nt +upstreamnt +downstreamnt
atgccgccctccgggctgcggctgctgccgctgctgctaccgctgctgtggctactggtg
ctgacgcctggccggccggccgcgggactatccacctgcaagactatcgacatggagctg
gtgaagcggaagcgcatcgaggccatccgcggccagatcctgtccaagctgcggctcgcc
agccccccgagccagggggaggtgccgcccggcccgctgcccgaggccgtgctcgccctg
tacaacagcacccgcgaccgggtggccggggagagtgcagaaccggagcccgagcctgag
gccgactactacgccaaggaggtcacccgcgtgctaatggtggaaacccacaacgaaatc
tatgacaagttcaagcagagtacacacagcatatatatgttcttcaacacatcagagctc
cgagaagcggtacctgaacccgtgttgctctcccgggcagagctgcgtctgctgaggctc
aagttaaaagtggagcagcacgtggagctgtaccagaaatacagcaacaattcctggcga
tacctcagcaaccggctgctggcacccagcgactcgccagagtggttatcttttgatgtc
accggagttgtgcggcagtggttgagccgtggaggggaaattgagggctttcgccttagc
gcccactgctcctgtgacagcagggataacacactgcaagtggacatcaacgggttcact
accggccgccgaggtgacctggccaccattcatggcatgaaccggcctttcctgcttctc
atggccaccccgctggagagggcccagcatctgcaaagctcccggcaccgccgagccctg
gacaccaactattgcttcagctccacggagaagaactgctgcgtgcggcagctgtacatt
gacttccgcaaggacctcggctggaagtggatccacgagcccaagggctaccatgccaac
ttctgcctcgggccctgcccctacatttggagcctggacacgcagtacagcaaggtcctg
gccctgtacaaccagcataacccgggcgcctcggcggcgccgtgctgcgtgccgcaggcg
ctggagccgctgcccatcgtgtactacgtgggccgcaagcccaaggtggagcagctgtcc
aacatgatcgtgcgctcctgcaagtgcagctga

DBGET integrated database retrieval system