KEGG   PATHWAY: jan00260
Entry
jan00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Jannaschia sp. CCS1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
jan00260  Glycine, serine and threonine metabolism
jan00260

Module
jan_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:jan00260]
jan_M00555  Betaine biosynthesis, choline => betaine [PATH:jan00260]
jan_M00621  Glycine cleavage system [PATH:jan00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Jannaschia sp. CCS1 [GN:jan]
Gene
Jann_3191  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Jann_0114  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Jann_2998  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Jann_3149  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Jann_2851  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Jann_2991  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Jann_2079  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Jann_1162  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Jann_2602  serine-glyoxylate aminotransferase apoenzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Jann_3472  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Jann_3650  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Jann_3926  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Jann_0379  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Jann_0261  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Jann_0260  phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]
Jann_0252  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Jann_0149  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
Jann_1933  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
Jann_3622  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Jann_3620  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Jann_1720  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Jann_0837  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Jann_3621  glycine cleavage system H protein [KO:K02437]
Jann_0016  Glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
Jann_2612  peptidase M24 [KO:K08688] [EC:3.5.3.3]
Jann_1492  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Jann_1493  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Jann_3794  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Jann_3937  Betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Jann_1481  FAD dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
Jann_1596  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Jann_0919  FAD dependent oxidoreductase [KO:K00315] [EC:1.5.8.4]
Jann_2805  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Jann_2488  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
Jann_2186  sarcosine oxidase alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Jann_2183  sarcosine oxidase beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Jann_2187  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Jann_2185  Sarcosine oxidase delta subunit heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Jann_0316  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Jann_1660  Pyridoxal-5'-phosphate-dependent enzyme beta subunit [KO:K01754] [EC:4.3.1.19]
Jann_0069  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Jann_2738  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Jann_3189  Pyridoxal-5'-phosphate-dependent enzyme beta subunit [KO:K01754] [EC:4.3.1.19]
Jann_2603  Pyridoxal-5'-phosphate-dependent enzyme beta subunit [KO:K01754] [EC:4.3.1.19]
Jann_3584  tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]
Jann_3589  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Jann_0850  peptidase M24 [KO:K15783] [EC:3.5.4.44]
Jann_0849  Succinylglutamate desuccinylase/aspartoacylase [KO:K15784] [EC:3.5.1.125]
Jann_0851  aminotransferase [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
jan00010  Glycolysis / Gluconeogenesis
jan00020  Citrate cycle (TCA cycle)
jan00230  Purine metabolism
jan00250  Alanine, aspartate and glutamate metabolism
jan00270  Cysteine and methionine metabolism
jan00290  Valine, leucine and isoleucine biosynthesis
jan00300  Lysine biosynthesis
jan00330  Arginine and proline metabolism
jan00460  Cyanoamino acid metabolism
jan00470  D-Amino acid metabolism
jan00564  Glycerophospholipid metabolism
jan00600  Sphingolipid metabolism
jan00620  Pyruvate metabolism
jan00630  Glyoxylate and dicarboxylate metabolism
jan00640  Propanoate metabolism
jan00680  Methane metabolism
jan00860  Porphyrin metabolism
jan00920  Sulfur metabolism
KO pathway
ko00260   
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