KEGG   PATHWAY: ko00627
Entry
ko00627                     Pathway                                
Name
Aminobenzoate degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ko00627  Aminobenzoate degradation
ko00627

Module
M00637  Anthranilate degradation, anthranilate => catechol [PATH:ko00627]
Other DBs
GO: 0043421
UMBBD: dcz 2,4-d pcp 2,4,5-t box dca
Orthology
K00141  xylC; benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28]
K01034  atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
K01035  atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
K01101  E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]
K01426  E3.5.1.4, amiE; amidase [EC:3.5.1.4]
K01501  E3.5.5.1; nitrilase [EC:3.5.5.1]
K01512  acyP; acylphosphatase [EC:3.6.1.7]
K01576  mdlC; benzoylformate decarboxylase [EC:4.1.1.7]
K01612  bsdC; vanillate/4-hydroxybenzoate decarboxylase subunit C [EC:4.1.1.- 4.1.1.61]
K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
K01721  nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]
K01781  mdlA; mandelate racemase [EC:5.1.2.2]
K01865  hab; (hydroxyamino)benzene mutase [EC:5.4.4.1]
K03186  ubiX, bsdB, PAD1; flavin prenyltransferase [EC:2.5.1.129]
K03380  E1.14.13.7; phenol 2-monooxygenase (NADPH) [EC:1.14.13.7]
K03862  vanA; vanillate monooxygenase [EC:1.14.13.82]
K03863  vanB; vanillate monooxygenase ferredoxin subunit
K04099  desB, galA; gallate dioxygenase [EC:1.13.11.57]
K04100  ligA; protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
K04101  ligB; protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
K04105  hbaA; 4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
K04107  hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1]
K04108  hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1]
K04109  hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1]
K04110  badA; benzoate-CoA ligase [EC:6.2.1.25]
K05599  antA; anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit [EC:1.14.12.1]
K05600  antB; anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit [EC:1.14.12.1]
K07511  ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]
K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07824  CYP53A1; benzoate 4-monooxygenase [EC:1.14.14.92]
K08295  abmG; 2-aminobenzoate-CoA ligase [EC:6.2.1.32]
K09461  E1.14.13.40; anthraniloyl-CoA monooxygenase [EC:1.14.13.40]
K10215  ethA; monooxygenase [EC:1.14.13.-]
K10219  ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K10221  ligI; 2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57]
K11311  antC; anthranilate 1,2-dioxygenase reductase component [EC:1.18.1.-]
K14333  DHBD; 2,3-dihydroxybenzoate decarboxylase [EC:4.1.1.46]
K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
K15054  mdlB; (S)-mandelate dehydrogenase [EC:1.1.99.31]
K15055  nbaA; 2-nitrobenzoate nitroreductase [EC:1.7.1.-]
K15056  nbaB; 2-hydroxylaminobenzoate mutase [EC:5.4.99.-]
K15057  nbzA; nitrobenzene nitroreductase [EC:1.7.1.16]
K15058  amnA; 2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit alpha
K15059  amnB; 2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit beta [EC:1.13.11.74 1.13.11.76]
K15060  ligXa; 5,5'-dehydrodivanillate O-demethylase oxygenase subunit [EC:1.14.13.-]
K15061  ligZ; OH-DDVA oxygenase
K15062  ligY; OH-DDVA meta-cleavage compound hydrolase
K15063  ligW; 5-carboxyvanillate decarboxylase
K15064  desA; syringate O-demethylase [EC:2.1.1.-]
K15065  desZ; 3-O-methylgallate 3,4-dioxygenase [EC:1.13.11.-]
K15066  ligM; vanillate/3-O-methylgallate O-demethylase [EC:2.1.1.341]
K16239  bsdC; 4-hydroxybenzoate decarboxylase subunit C [EC:4.1.1.61]
K16319  andAc; anthranilate 1,2-dioxygenase large subunit [EC:1.14.12.1]
K16320  andAd; anthranilate 1,2-dioxygenase small subunit [EC:1.14.12.1]
K18248  andAb; anthranilate 1,2-dioxygenase ferredoxin component
K18249  andAa; anthranilate 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.-]
K18541  mdlY; mandelamide amidase [EC:3.5.1.86]
K19709  ydiF; acetate CoA-transferase [EC:2.8.3.8]
K20458  hcl; 3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase [EC:6.2.1.37 6.2.1.27]
K20712  glnA; 3-(hydroxyamino)phenol mutase [EC:5.4.4.3]
K20807  nthB; nitrile hydratase subunit beta [EC:4.2.1.84]
K20990  E3.1.1.92; 4-sulfomuconolactone hydrolase [EC:3.1.1.92]
K21725  pnpA; 4-nitrocatechol/4-nitrophenol 4-monooxygenase [EC:1.14.13.166 1.14.13.167]
K21726  npcA; 4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, oxygenase component [EC:1.14.13.29 1.14.13.166]
K21727  npcB; 4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, reductase component
K21759  bsdD; vanillate/4-hydroxybenzoate decarboxylase subunit D [EC:4.1.1.- 4.1.1.61]
K21802  vdh; vanillin dehydrogenase [EC:1.2.1.67]
K22958  lpdC; gallate decarboxylase subunit C
K22959  lpdB; gallate decarboxylase subunit B
K22960  lpdD; gallate decarboxylase subunit D
K23526  gcoA; aromatic O-demethylase, cytochrome P450 subunit
K23527  gcoB; aromatic O-demethylase, reductase subunit
K23528  pnpB; p-benzoquinone reductase (NADPH)
K23529  E1.6.5.7; 2-hydroxy-1,4-benzoquinone reductase
K24244  ligXc; 5,5'-dehydrodivanillate O-demethylase ferredoxin subunit
K24245  ligXd; 5,5'-dehydrodivanillate O-demethylase ferredoxin reductase subunit
K25916  mtvB, mtoB; methoxylated aromatic compound---corrinoid protein Co-methyltransferase
K25932  ppcA; phenyl-phosphate phosphatase/carboxylase subunit alpha
K25933  ppcB; phenyl-phosphate phosphatase/carboxylase subunit beta
K25934  ppcC; phenyl-phosphate phosphatase/carboxylase subunit gamma
K25935  ppcD; phenyl-phosphate phosphatase/carboxylase subunit delta
K25936  ppsA; phenol phosphorylase subunit alpha
K25937  ppsB; phenol phosphorylase subunit beta
K25938  ppsC; phenol phosphorylase subunit delta gamma
Compound
C00090  Catechol
C00108  Anthranilate
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00261  Benzaldehyde
C00292  Aniline
C00472  p-Benzoquinone
C00512  Benzoyl-CoA
C00530  Hydroquinone
C00568  4-Aminobenzoate
C00632  3-Hydroxyanthranilate
C00633  4-Hydroxybenzaldehyde
C00755  4-Hydroxy-3-methoxy-benzaldehyde
C00870  4-Nitrophenol
C00877  Crotonoyl-CoA
C01108  1,2,3-Trihydroxybenzene
C01144  (S)-3-Hydroxybutanoyl-CoA
C01424  Gallate
C01502  o-Methoxyphenol
C01983  (R)-Mandelate
C01984  (S)-Mandelate
C01987  2-Aminophenol
C02137  alpha-Oxo-benzeneacetic acid
C02183  Phloroglucinol
C02222  2-Maleylacetate
C02235  4-Nitrocatechol
C02247  Anthraniloyl-CoA
C02372  4-Hydroxyaniline
C02720  Hydroxylaminobenzene
C02734  Phenolic phosphate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03198  (S)-4-Hydroxymandelate
C03360  4-Nitrophenyl phosphate
C03590  4-Hydroxyphenylglyoxylate
C03671  2-Pyrone-4,6-dicarboxylate
C03824  2-Aminomuconate semialdehyde
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C05165  2-Amino-5-oxocyclohex-1-enecarbonyl-CoA
C05616  3-O-Methylgallate
C06206  Benzoyl phosphate
C06317  Vanillyl alcohol
C06335  4-Aminobenzenesulfonate
C06337  Terephthalate
C06604  Parathion
C06605  Aminoparathion
C06606  Paraoxon
C06607  Diethylthiophosphoric acid
C06608  Diethylphosphoric acid
C06672  Vanillate
C06673  4-Carboxy-4'-sulfoazobenzene
C06674  4-Sulfocatechol
C06675  3-Sulfomuconate
C06676  4-Sulfolactone
C06719  Dihydrophloroglucinol
C06813  Nitrobenzene
C06876  Nitrosobenzene
C07103  2-Hydroxy-1,4-benzoquinone
C07301  (R)-Mandelamide
C08063  1,4-Cyclohexanedione
C09814  Benzonitrile
C09815  Benzamide
C10833  Syringic acid
C14418  3-Nitrophenol
C14602  3-Hydroxyaminophenol
C14604  Aminohydroquinone
C16200  Phenylboronic acid
C16234  o-Nitrobenzoate
C16235  o-Hydroxylaminobenzoate
C16267  Cyclopropanecarboxylate
C16268  Cyclopropanecarboxyl-CoA
C16272  3-Hydroxy-5-oxohexanoate
C16273  3-Hydroxy-5-oxohexanoyl-CoA
C16281  Thiobenzamide
C16283  Thiobenzamide S-oxide
C16285  Thiobenzamide S,S-dioxide
C18338  5-Carboxyvanillic acid
C18345  4-Carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate
C18347  5,5'-Dehydrodivanillate
C18348  2,2',3-Trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl
C18349  4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate
C18351  4-Aminocatechol
Reference
PMID:3078743
  Authors
Fewson CA
  Title
Microbial metabolism of mandelate: a microcosm of diversity.
  Journal
FEMS Microbiol Rev 4:85-110 (1988)
DOI:10.1111/j.1574-6968.1988.tb02737.x
Reference
PMID:12670968
  Authors
McLeish MJ, Kneen MM, Gopalakrishna KN, Koo CW, Babbitt PC, Gerlt JA, Kenyon GL
  Title
Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.
  Journal
J Bacteriol 185:2451-6 (2003)
DOI:10.1128/JB.185.8.2451-2456.2003
Reference
PMID:8782397
  Authors
Shimao M, Nakamura T, Okuda A, Harayama S.
  Title
Characteristics of transposon insertion mutants of mandelic acid-utilizing Pseudomonas putida strain A10L.
  Journal
Biosci Biotechnol Biochem 60:1051-5 (1996)
DOI:10.1271/bbb.60.1051
Reference
PMID:11344134
  Authors
Naidu D, Ragsdale SW.
  Title
Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica.
  Journal
J Bacteriol 183:3276-81 (2001)
DOI:10.1128/JB.183.11.3276-3281.2001
Reference
PMID:14711645
  Authors
Toraya T, Oka T, Ando M, Yamanishi M, Nishihara H.
  Title
Novel pathway for utilization of cyclopropanecarboxylate by Rhodococcus rhodochrous.
  Journal
Appl Environ Microbiol 70:224-8 (2004)
DOI:10.1128/AEM.70.1.224-228.2004
Related
pathway
ko00362  Benzoate degradation
ko00380  Tryptophan metabolism

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