PATHWAY: ko04149 Help
Entry Name Peroxisome - yeast
Description Peroxisomes are dynamic organelles essential for fatty acid beta-oxidation and hydrogen peroxide detoxification. Biogenesis occurs via two co-existing pathways. In growth and division, pre-existing peroxisomes import PMPs post-translationally from the cytosol, mainly via the Pex19-Pex3 system (direct pathway). Matrix proteins are imported via PTS1 (receptor Pex5) or PTS2 (Pex7 with co-receptor). Receptors recycle via mono-ubiquitination and the AAA ATPases Pex1/Pex6. Peroxisome elongation and fission are driven by the Pex11 family proteins, Fis1, and Dnm1. In de novo biogenesis (when peroxisomes are absent), certain PMPs insert into the ER (via Sec61 or GET pathway), sort to pre-peroxisomal ER domains, and bud as pre-peroxisomal vesicles (ppVs). Distinct ppV populations fuse to form import-competent peroxisomes. The Pex30 family proteins help regulate ER shaping and ppV formation. Pex11 and Pex30 family proteins also mediate peroxisome-organelle membrane contact sites. The system is highly flexible, allowing rapid adaptation to metabolic needs.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Orthology K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8 ]
K01068 ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2 ]
K01551 arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
K01897 ACSL, fadD; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3 ]
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K06030 MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
K06944 DRG1, RBG1; developmentally-regulated GTP-binding protein 1 [EC:3.6.5.-]
K07342 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
K08745 SLC27A1_4, FATP1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K09481 SEC61B, SBH2; protein transport protein SEC61 subunit beta
K10956 SEC61A; protein transport protein SEC61 subunit alpha
K12200 PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
K13237 DECR2, SPS19; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], peroxisomal [EC:1.3.1.124 ]
K13239 ECI2, PECI, ECI1; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8 ]
K13338 PEX1; peroxin-1 [EC:3.6.4.-]
K13339 PEX6, PXAAA1; peroxin-6 [EC:3.6.4.-]
K13345 PEX12, PAF3; peroxin-12
K13354 SLC25A17, PMP34; solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17
K14454 GOT1, AAT2; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1 ]
K14729 FOX2; multifunctional beta-oxidation protein [EC:4.2.1.- 1.1.1.-]
K15628 PXA; ATP-binding cassette, subfamily D (ALD), peroxisomal long-chain fatty acid import protein [EC:7.6.2.4 ]
K17279 REEP5_6, YOP1; receptor expression-enhancing protein 5/6
K17775 MDM34, MMM2; mitochondrial distribution and morphology protein 34
K17969 FIS1, TTC11, MDV2; mitochondrial fission 1 protein
K17970 MDV1, FIS2; mitochondrial division protein 1
K22138 MPC1; mitochondrial pyruvate carrier 1
K22139 MPC2; mitochondrial pyruvate carrier 2
K28901 PEX8; peroxisomal biogenesis factor 8
K28902 PEX17; peroxisomal membrane protein 17
K28903 PEX18_21; peroxisomal membrane protein 18/21
K28904 PEX22; peroxisome assembly protein 22
K28905 PEX25_27; peroxisomal membrane protein 25/27
K28906 PEX28_29; peroxisomal membrane protein 28/29
K28907 PEX30_31_32; peroxisomal membrane protein 30/31/32
K28908 PEX34; peroxisomal membrane protein 34
K28910 PEX39; peroxisomal biogenesis factor 39
K28992 RTN; reticulon-like protein
K28993 PEX9; peroxisome biogenesis protein 9
K28994 INP2; inheritance of peroxisomes protein 2
K28995 INP1; inheritance of peroxisomes protein 1
K28996 LPX1; peroxisomal membrane protein LPX1
K28997 LPX2; peroxisomal membrane protein LPX2
K28999 PXP2; peroxisomal protein 2
K29001 GTO; glutathione dehydrogenase/transferase
Reference Authors Deori NM, Nagotu S
Title Peroxisome biogenesis and inter-organelle communication: an indispensable role for Pex11 and Pex30 family proteins in yeast.
Journal Reference Authors Farre JC, Mahalingam SS, Proietto M, Subramani S
Title Peroxisome biogenesis, membrane contact sites, and quality control.
Journal Reference Authors Kumar R, Islinger M, Worthy H, Carmichael R, Schrader M
Title The peroxisome: an update on mysteries 3.0.
Journal Reference Authors Das H, Oeljeklaus S, Maier R, Bender J, Warscheid B
Title The yeast peroxisomal proteome at absolute quantitative scale.
Journal Reference Authors Subramani S, Shukla N, Farre JC
Title Convergent and divergent mechanisms of peroxisomal and mitochondrial division.
Journal Reference Authors Deori NM, Kale A, Maurya PK, Nagotu S
Title Peroxisomes: role in cellular ageing and age related disorders.
Journal Related ko00270 Cysteine and methionine metabolism
ko00630 Glyoxylate and dicarboxylate metabolism
