KEGG PATHWAY: mbb00270

PATHWAY: mbb00270

Entry

mbb00270                    Pathway

Name

Cysteine and methionine metabolism - Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

mbb00270

Cysteine and methionine metabolism

Module

mbb_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:mbb00270]

mbb_M00021

Cysteine biosynthesis, serine => cysteine [PATH:mbb00270]

Other DBs

GO:	0006534 0006555

Organism

Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 [GN:mbb]

Gene

BCG_0100c

sdaA; Probable l-serine dehydratase sdaA [KO:K01752] [EC:4.3.1.17]

BCG_0106

[KO:K14155] [EC:4.4.1.13]

BCG_0124

mtn; Probable bifunctional mta/sah nucleosidase mtn [KO:K01243] [EC:3.2.2.9]

BCG_0428

metZ; Probable o-succinylhomoserine sulfhydrylase metZ [KO:K10764] [EC:2.5.1.-]

BCG_0579

pnp; Probable 5'-methylthioadenosine phosphorylase pnp [KO:K00772] [EC:2.4.2.28]

BCG_0778c

serA2; Possible D-3-phosphoglycerate dehydrogenase serA2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BCG_0867c

cysA2; Probable thiosulfate sulfurtransferase cysA2 [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCG_0900

cysK2; Possible cysteine synthase a cysK2 [KO:K22847] [EC:2.8.5.1]

BCG_0936c

serC; Possible phosphoserine aminotransferase serC [KO:K00831] [EC:2.6.1.52]

BCG_1135

cbs; Probable cystathionine beta-synthase cbs [KO:K01697] [EC:4.2.1.22]

BCG_1137

metB; Probable cystathionine gamma-synthase metB [KO:K01739] [EC:2.5.1.48]

BCG_1194c

metE; Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase metE [KO:K00549] [EC:2.1.1.14]

BCG_1300

mdh; Probable malate dehydrogenase mdh [KO:K00024] [EC:1.1.1.37]

BCG_1354

thrA; Probable homoserine dehydrogenase thrA [KO:K00003] [EC:1.1.1.3]

BCG_1356

thrB; Probable homoserine kinase thrB [KO:K00872] [EC:2.7.1.39]

BCG_1453

metK; Probable S-adenosylmethionine synthetase metK [KO:K00789] [EC:2.5.1.6]

BCG_2141c

metH; Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS) [KO:K00548] [EC:2.1.1.13]

BCG_2166c

yfiH; conserved hypothetical protein yfiH [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

BCG_2226c

ilvE; Probable branched-chain amino acid transaminase ilvE [KO:K00826] [EC:2.6.1.42]

BCG_2308

sseB; Probable thiosulfate sulfurtransferase SseB [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCG_2310

[KO:K14155] [EC:4.4.1.13]

BCG_2356

cysK1; Probable cysteine synthase A cysK1 [KO:K01738] [EC:2.5.1.47]

BCG_2357

[KO:K00640] [EC:2.3.1.30]

BCG_2478

mmuM; Probable homocysteine S-methyltransferase mmuM [KO:K00547] [EC:2.1.1.10]

BCG_2625

speE; Putative spermidine synthase speE [KO:K00797] [EC:2.5.1.16]

BCG_3017c

serA1; Probable D-3-phosphoglycerate dehydrogenase serA1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BCG_3142

cysA3; Probable thiosulfate sulfurtransferase cysA3 [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCG_3277c

sahH; Probable adenosylhomocysteinase sahH [KO:K01251] [EC:3.13.2.1]

BCG_3312

sseA; Probable thiosulfate sulfurtransferase sseA [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCG_3410

metC; Probable O-acetylhomoserine sulfhydrylase metC [KO:K01740] [EC:2.5.1.49]

BCG_3411

metA; Probable homoserine O-acetyltransferase metA [KO:K00641] [EC:2.3.1.31 2.3.1.46]

BCG_3743

[KO:K01738] [EC:2.5.1.47]

BCG_3763c

gshA; Glutamate--cysteine ligase gshA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE) [KO:K01919] [EC:6.3.2.2]

BCG_3768c

asd; Aspartate-semialdehyde dehydrogenase asd [KO:K00133] [EC:1.2.1.11]

BCG_3769c

ask; ASpartokinase ask [KO:K00928] [EC:2.7.2.4]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors