KEGG   PATHWAY: mcc04142
Entry
mcc04142                    Pathway                                
Name
Lysosome - Macaca mulatta (rhesus monkey)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcc04142  Lysosome
mcc04142

Other DBs
GO: 0005764
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424037  [KO:K01365] [EC:3.4.22.15]
100424758  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
100425716  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100430586  AP3M2; AP-3 complex subunit mu-2 isoform X2 [KO:K12398]
100430853  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
106995374  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
106996913  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
106998222  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
114674079  [KO:K08565] [EC:3.4.23.-]
114675527  [KO:K14410] [EC:3.1.3.2]
114677611  [KO:K02155]
574112  CTSK; cathepsin K precursor [KO:K01371] [EC:3.4.22.38]
574213  LAMP3; lysosome-associated membrane glycoprotein 3 precursor [KO:K06562]
677692  [KO:K01195] [EC:3.2.1.31]
677865  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154]
693322  GALC; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
693323  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
693377  PPT1; palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
693444  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
693659  CLTA; clathrin light chain A isoform X1 [KO:K04644]
693838  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
693954  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
693986  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
694091  AP3B2; AP-3 complex subunit beta-2 isoform X2 [KO:K12397]
694157  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
694569  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
695240  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase precursor [KO:K01052] [EC:3.1.1.13]
695302  WDR7; WD repeat-containing protein 7 isoform X4 [KO:K24738]
695379  LAMP2; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528]
696128  [KO:K01197] [EC:3.2.1.35]
696202  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
696249  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
696352  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
696644  AP3S1; AP-3 complex subunit sigma-1 isoform X3 [KO:K12399]
696805  HYAL4; hyaluronidase-4 isoform X1 [KO:K01197] [EC:3.2.1.35]
697307  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
697331  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
697348  GUSBA; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
697850  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
697929  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
698117  DMXL1; dmX-like protein 1 isoform X2 [KO:K24155]
698251  HEXA; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
698310  SORT1; sortilin isoform X1 [KO:K12388]
698345  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
699242  CD164; sialomucin core protein 24 precursor [KO:K06546]
699740  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor [KO:K01444] [EC:3.5.1.26]
699868  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
699881  NPC2; epididymal secretory protein E1 precursor [KO:K13443]
699990  SCARB2; lysosome membrane protein 2 [KO:K12384]
700421  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
700611  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
700835  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
700892  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
701025  SLC11A1; natural resistance-associated macrophage protein 1 isoform X4 [KO:K12347]
701217  AP3S2; AP-3 complex subunit sigma-2 [KO:K12399]
701298  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
702233  CLTB; clathrin light chain B isoform X1 [KO:K04645]
702243  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
702484  HYAL2; hyaluronidase-2 precursor [KO:K01197] [EC:3.2.1.35]
702619  PLA2G15; group XV phospholipase A2 precursor [KO:K06129] [EC:3.1.1.5]
702648  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
702850  HYAL1; hyaluronidase-1 isoform X2 [KO:K01197] [EC:3.2.1.35]
703129  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
703220  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
703534  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
703699  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
703734  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
703775  MCOLN1; mucolipin-1 [KO:K04992]
704041  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
704112  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
704464  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
705320  CTSC; dipeptidyl peptidase 1 precursor [KO:K01275] [EC:3.4.14.1]
705729  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
705751  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
705815  CLN3; battenin isoform X1 [KO:K12389]
706721  CTNS; cystinosin isoform X6 [KO:K12386]
707167  [KO:K01365] [EC:3.4.22.15]
707186  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
707352  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
707634  AP4B1; AP-4 complex subunit beta-1 isoform X2 [KO:K12401]
707709  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
708080  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
708592  CTSA; lysosomal protective protein precursor [KO:K13289] [EC:3.4.16.5]
708754  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
709136  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
709355  GLB1; LOW QUALITY PROTEIN: beta-galactosidase [KO:K12309] [EC:3.2.1.23]
709510  PSAP; prosaposin isoform X1 [KO:K12382]
709828  CD63; CD63 antigen [KO:K06497]
709838  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
710162  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
710171  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
710197  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
710257  AP1S3; AP-1 complex subunit sigma-3 isoform X2 [KO:K12395]
710650  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
710850  CTSV; cathepsin L2 isoform X2 [KO:K01375] [EC:3.4.22.43]
710944  AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402]
710993  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
711248  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
711437  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
711563  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
711743  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
712054  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
712531  MANBA; beta-mannosidase isoform X2 [KO:K01192] [EC:3.2.1.25]
712861  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
713068  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
713244  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
713336  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
713375  GM2A; ganglioside GM2 activator [KO:K12383]
713743  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
713744  ACP2; lysosomal acid phosphatase isoform 1 precursor [KO:K14410] [EC:3.1.3.2]
714237  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
714638  AP1B1; AP-1 complex subunit beta-1 isoform X7 [KO:K12392]
715071  ACP5; tartrate-resistant acid phosphatase type 5 precursor [KO:K14379] [EC:3.1.3.2]
715492  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
715505  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
715923  CD68; macrosialin [KO:K06501]
716100  SLC17A5; sialin [KO:K12301]
716173  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
716440  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
716500  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
716696  M6PR; cation-dependent mannose-6-phosphate receptor isoform X2 [KO:K10089]
716740  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
716802  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
717146  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
717197  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
717212  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
717500  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
717977  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
718372  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
718605  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
718912  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
719087  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
719103  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
719235  [KO:K08565] [EC:3.4.23.-]
719569  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
720331  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
720531  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
721631  ABCA2; ATP-binding cassette sub-family A member 2 isoform X3 [KO:K05642]
722441  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma precursor [KO:K10087]
722684  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mcc00511  Other glycan degradation
mcc00531  Glycosaminoglycan degradation
mcc04130  SNARE interactions in vesicular transport
mcc04140  Autophagy - animal
mcc04144  Endocytosis
KO pathway
ko04142   

DBGET integrated database retrieval system