KEGG   PATHWAY: mdi00630
Entry
mdi00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Methylorubrum extorquens DM4
Class
Metabolism; Carbohydrate metabolism
Pathway map
mdi00630  Glyoxylate and dicarboxylate metabolism
mdi00630

Module
mdi_M00621  Glycine cleavage system [PATH:mdi00630]
mdi_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mdi00630]
Other DBs
GO: 0046487 0043648
Organism
Methylorubrum extorquens DM4 [GN:mdi]
Gene
METDI0111  [KO:K03781] [EC:1.11.1.6]
METDI0153  [KO:K01091] [EC:3.1.3.18]
METDI0155  pccB; propionyl-CoA carboxylase beta chain [KO:K01966] [EC:6.4.1.3 2.1.3.15]
METDI0161  ccr; crotonyl-CoA carboxylase/reductase [KO:K14446] [EC:1.3.1.85]
METDI0162  katA; catalase (hydroperoxidase II) [KO:K03781] [EC:1.11.1.6]
METDI0163  ecm; ethylmalonyl-CoA mutase [KO:K14447] [EC:5.4.99.63]
METDI0454  fdh3A; formate dehydrogenase alpha subunit precursor (tat pathway signal) [KO:K00123] [EC:1.17.1.9]
METDI0455  fdh3B; Formate dehydrogenase iron-sulfur (beta) subunit [KO:K00124]
METDI0456  fdh3C; Formate dehydrogenase gamma (cytochrome) subunit [KO:K00127]
METDI0491  [KO:K00015] [EC:1.1.1.26]
METDI0990  gcvP; glycine dehydrogenase / decarboxylase [KO:K00281] [EC:1.4.4.2]
METDI0991  gcvH; glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437]
METDI0992  gcvT; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [KO:K00605] [EC:2.1.2.10]
METDI1066  [KO:K00104] [EC:1.1.99.14]
METDI1373  ttuC; Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
METDI1374  [KO:K11529] [EC:2.7.1.165]
METDI1550  epi; ethylmalonyl-CoA/methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
METDI1787  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
METDI1789  [KO:K01577] [EC:4.1.1.8]
METDI1800  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
METDI2311  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
METDI2316  lpd; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]
METDI2378  aimF; Formamidase (Formamide amidohydrolase) [KO:K01455] [EC:3.5.1.49]
METDI2478  sga; serine-glyoxylate aminotransferase (SGAT) [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
METDI2479  hprA; Hydroxypyruvate reductase, NAD(P)H-dependent [KO:K00018] [EC:1.1.1.29]
METDI2482  mtkA; Malate thiokinase, large subunit [KO:K14067] [EC:6.2.1.9]
METDI2483  mtkB; Malate thiokinase, small subunit [KO:K08692] [EC:6.2.1.9]
METDI2485  mcl; malyl-CoA lyase/beta-methylmalyl-CoA lyase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
METDI2616  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
METDI2773  eda; multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
METDI2814  [KO:K01091] [EC:3.1.3.18]
METDI2912  [KO:K22133] [EC:6.2.1.8]
METDI3005  msd; methylsuccinyl-CoA dehydrogenase [KO:K14448] [EC:1.3.8.12]
METDI3078  [KO:K01091] [EC:3.1.3.18]
METDI3096  [KO:K03781] [EC:1.11.1.6]
METDI3157  glnII; glutamine synthetase II [KO:K01915] [EC:6.3.1.2]
METDI3158  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
METDI3170  mcmB; methylmalonyl-CoA beta subunit [KO:K01847] [EC:5.4.99.2]
METDI3295  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
METDI3393  acnA; aconitate hydratase [KO:K27802]
METDI3412  [KO:K00042] [EC:1.1.1.60]
METDI3513  gck; glycerate kinase [KO:K11529] [EC:2.7.1.165]
METDI3557  lpd; dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex [KO:K00382] [EC:1.8.1.4]
METDI3767  pccA; propionyl-CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
METDI3939  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
METDI3959  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
METDI3998  katA; catalase (hydroperoxidase II) [KO:K03781] [EC:1.11.1.6]
METDI4034  [KO:K00626] [EC:2.3.1.9]
METDI4177  fmdA; formamidase [KO:K01455] [EC:3.5.1.49]
METDI4248  croR; crotonase [KO:K17865] [EC:4.2.1.55]
METDI4272  phaA; beta-ketothiolase [KO:K00626] [EC:2.3.1.9]
METDI4273  phaB; acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
METDI4690  [KO:K01915] [EC:6.3.1.2]
METDI4744  mcd; mesaconyl-CoA hydratase [KO:K14449] [EC:4.2.1.148]
METDI4906  [KO:K08691] [EC:4.1.3.24 4.1.3.25]
METDI5075  [KO:K00382] [EC:1.8.1.4]
METDI5202  sga; serine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
METDI5204  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
METDI5437  fdh2C; NAD-dependent formate dehydrogenase, Molybdenum containing, gamma subunit [KO:K00127]
METDI5438  fdh2B; NAD-dependent formate dehydrogenase, Molybdenum containing, beta subunit [KO:K00124]
METDI5439  fdh2A; NAD-dependent formate dehydrogenase, molybdenum containing, alpha subunit [KO:K00123] [EC:1.17.1.9]
METDI5440  fdh2D; NAD-linked formate dehydrogenase, Molybdenum containing, delta subunit [KO:K00126] [EC:1.17.1.9]
METDI5469  [KO:K01895] [EC:6.2.1.1]
METDI5632  fdh1B; Tungsten-containing formate dehydrogenase beta subunit [KO:K22515] [EC:1.17.1.9]
METDI5633  fdh1A; Tungsten-containing formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
METDI5733  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
METDI5741  ttuC; Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]) [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
METDI5844  [KO:K11472] [EC:1.1.99.14]
METDI5851  mcmA; methylmalonyl-CoA mutase, alpha subunit [KO:K01847] [EC:5.4.99.2]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mdi00010  Glycolysis / Gluconeogenesis
mdi00020  Citrate cycle (TCA cycle)
mdi00030  Pentose phosphate pathway
mdi00053  Ascorbate and aldarate metabolism
mdi00071  Fatty acid degradation
mdi00230  Purine metabolism
mdi00250  Alanine, aspartate and glutamate metabolism
mdi00260  Glycine, serine and threonine metabolism
mdi00270  Cysteine and methionine metabolism
mdi00620  Pyruvate metabolism
mdi00710  Carbon fixation by Calvin cycle
mdi00750  Vitamin B6 metabolism
mdi00910  Nitrogen metabolism
KO pathway
ko00630   

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