KEGG PATHWAY: mdi00260

PATHWAY: mdi00260

Entry

mdi00260                    Pathway

Name

Glycine, serine and threonine metabolism - Methylorubrum extorquens DM4

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mdi00260

Glycine, serine and threonine metabolism

Module

mdi_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mdi00260]

mdi_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mdi00260]

mdi_M00621

Glycine cleavage system [PATH:mdi00260]

mdi_M00975

Betaine degradation, bacteria, betaine => pyruvate [PATH:mdi00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Methylorubrum extorquens DM4 [GN:mdi]

Gene

METDI0054

trpB; tryptophan synthase, beta protein [KO:K01696] [EC:4.2.1.20]

METDI0094

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

METDI0525

[KO:K00639] [EC:2.3.1.29]

METDI0640

serC1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

METDI0641

serA2; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

METDI0990

gcvP; glycine dehydrogenase / decarboxylase [KO:K00281] [EC:1.4.4.2]

METDI0991

gcvH; glycine cleavage complex protein H, carrier of aminomethyl moiety via covalently bound lipoyl cofactor [KO:K02437]

METDI0992

gcvT; glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent [KO:K00605] [EC:2.1.2.10]

METDI1104

ask; aspartate kinase [KO:K00928] [EC:2.7.2.4]

METDI1374

[KO:K11529] [EC:2.7.1.165]

METDI1921

[KO:K01834] [EC:5.4.2.11]

METDI1962

gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]

METDI2316

lpd; dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]

METDI2478

sga; serine-glyoxylate aminotransferase (SGAT) [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

METDI2479

hprA; Hydroxypyruvate reductase, NAD(P)H-dependent [KO:K00018] [EC:1.1.1.29]

METDI2672

[KO:K01834] [EC:5.4.2.11]

METDI2730

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

METDI2755

hemA; 5-aminolevulinic acid synthase (ALAS) [KO:K00643] [EC:2.3.1.37]

METDI3234

gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]

METDI3327

thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]

METDI3414

[KO:K01079] [EC:3.1.3.3]

METDI3465

asdB; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

METDI3513

gck; glycerate kinase [KO:K11529] [EC:2.7.1.165]

METDI3557

lpd; dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex [KO:K00382] [EC:1.8.1.4]

METDI3806

ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]

METDI3905

ltaE; Low-specificity L-threonine aldolase (Low-specificity L-TA) [KO:K01620] [EC:4.1.2.48]

METDI3959

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

METDI4045

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

METDI4255

gatm; Glycine amidinotransferase (L-arginine:glycine amidinotransferase) [KO:K00613] [EC:2.1.4.1]

METDI4482

serC2; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

METDI4700

soxB; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]

METDI4701

soxD; sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

METDI4702

soxA; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

METDI4703

soxG; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]

METDI4704

sdaB; L-serine deaminase [KO:K01752] [EC:4.3.1.17]

METDI4707

[KO:K25961]

METDI4708

[KO:K25960]

METDI4709

[KO:K21834]

METDI4710

[KO:K21833] [EC:1.5.7.3]

METDI4711

[KO:K21832] [EC:1.14.13.251]

METDI4712

[KO:K00479] [EC:1.14.13.251]

METDI5075

[KO:K00382] [EC:1.8.1.4]

METDI5202

sga; serine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

METDI5413

[KO:K00274] [EC:1.4.3.4]

METDI5482

trpA; tryptophan synthase alpha subunit [KO:K01695] [EC:4.2.1.20]

METDI5701

[KO:K01620] [EC:4.1.2.48]

METDI5793

pssA; phosphatidylserine synthase (pssA-like) [KO:K17103] [EC:2.7.8.8]

METDI5861

hemA; 5-aminolevulinic acid synthase (ALAS) [KO:K00643] [EC:2.3.1.37]

p1METDI0026

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721