KEGG   PATHWAY: mlk00330
Entry
mlk00330                    Pathway                                
Name
Arginine and proline metabolism - Mustela lutreola (European mink)
Class
Metabolism; Amino acid metabolism
Pathway map
mlk00330  Arginine and proline metabolism
mlk00330

Module
mlk_M00015  Proline biosynthesis, glutamate => proline [PATH:mlk00330]
mlk_M00047  Creatine pathway [PATH:mlk00330]
mlk_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:mlk00330]
mlk_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:mlk00330]
mlk_M00970  Proline degradation, proline => glutamate [PATH:mlk00330]
mlk_M00972  Proline metabolism [PATH:mlk00330]
Other DBs
GO: 0006525 0006560
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131836233  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
131823198  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
131836199  CKMT1A; creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
131837027  CKB; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
131832413  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
131818473  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
131809366  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
131826959  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
131807375  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
131831734  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
131810478  LOW QUALITY PROTEIN: antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
131809749  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
131821178  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
131826643  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
131833508  AMD1; S-adenosylmethionine decarboxylase proenzyme isoform X1 [KO:K01611] [EC:4.1.1.50]
131829933  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
131808002  SMOX; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
131818934  ALDH16A1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
131811581  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
131812893  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
131815795  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
131832544  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
131815098  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
131810850  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
131810851  CNDP2; cytosolic non-specific dipeptidase isoform X1 [KO:K08660] [EC:3.4.13.18]
131816424  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
131821609  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
131816471  SAT2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
131821712  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
131822198  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
131810054  AGMAT; guanidino acid hydrolase, mitochondrial isoform X1 [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
131811917  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
131816344  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
131829935  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
131836712  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
131833799  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
131830575  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
131827775  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
131814563  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
131816832  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
131811034  PRODH; proline dehydrogenase 1, mitochondrial isoform X1 [KO:K00318] [EC:1.5.5.2]
131809489  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
131828615  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
131825495  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
131828836  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
131807461  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X1 [KO:K00472] [EC:1.14.11.2]
131832014  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
131818468  PRODH2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
131820473  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
131828562  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
131818234  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
131828583  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
131811459  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
131836632  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
mlk00020  Citrate cycle (TCA cycle)
mlk00220  Arginine biosynthesis
mlk00250  Alanine, aspartate and glutamate metabolism
mlk00260  Glycine, serine and threonine metabolism
mlk00270  Cysteine and methionine metabolism
mlk00310  Lysine degradation
mlk00410  beta-Alanine metabolism
mlk00470  D-Amino acid metabolism
mlk00480  Glutathione metabolism
mlk00630  Glyoxylate and dicarboxylate metabolism
mlk00650  Butanoate metabolism
mlk00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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