KEGG   PATHWAY: mmea04514
Entry
mmea04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Malurus melanocephalus (red-backed fairy wren)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mmea04514  Cell adhesion molecule (CAM) interaction
mmea04514

Other DBs
GO: 0050839
Organism
Malurus melanocephalus (red-backed fairy wren) [GN:mmea]
Gene
130572168  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
130572214  ITGA4; integrin alpha-4 [KO:K06483]
130572524  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
130572546  NTNG1; netrin-G1 isoform X1 [KO:K07522]
130572558  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
130572871  CLDN20; claudin-20 [KO:K06087]
130573507  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
130573598  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
130573599  CNTN1; contactin-1 [KO:K06759]
130573649  CLDN10; claudin-10 isoform X1 [KO:K06087]
130573667  SDC2; syndecan-2 [KO:K16336]
130574085  PDCD1; programmed cell death protein 1 [KO:K06744]
130574181  CDH2; cadherin-2 [KO:K06736]
130574547  [KO:K06087]
130574619  [KO:K06087]
130574622  [KO:K06087]
130574787  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
130575013  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
130575153  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
130575272  CLDN5; claudin-5 [KO:K06087]
130575475  NLGN1; neuroligin-1 [KO:K07378]
130575485  CLDN11; claudin-11 [KO:K06087]
130575890  CLDN2; claudin-2 [KO:K06087]
130575966  [KO:K06087]
130576029  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
130576714  NTNG2; netrin-G2 isoform X1 [KO:K16359]
130576738  ITGB8; integrin beta-8 [KO:K06591]
130576777  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
130576875  NECTIN3; nectin-3 [KO:K06592]
130576881  JAM2; LOW QUALITY PROTEIN: junctional adhesion molecule B isoform X1 [KO:K06735]
130577117  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
130577118  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
130577331  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
130577361  [KO:K07377]
130577365  CDH5; cadherin-5 [KO:K06533]
130577463  [KO:K06713]
130577481  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
130577484  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
130577624  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
130577788  [KO:K06777] [EC:3.1.3.48]
130577903  XG; glycoprotein Xg [KO:K06520]
130577908  CD99; CD99 antigen isoform X1 [KO:K06520]
130577985  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
130578086  ALCAM; CD166 antigen [KO:K06547]
130578288  [KO:K06087]
130578865  CLDN23; claudin-23 [KO:K06087]
130578954  CD99L2; LOW QUALITY PROTEIN: CD99 antigen-like protein 2 [KO:K06520]
130579397  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
130579448  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
130579536  GLG1; Golgi apparatus protein 1 [KO:K06816]
130579596  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
130579746  CLDN12; claudin-12 [KO:K06087]
130579972  [KO:K06496]
130580007  CLDN14; claudin-14 [KO:K06087]
130580075  CD6; T-cell differentiation antigen CD6 [KO:K06456]
130580122  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
130580208  MADCAM1; LOW QUALITY PROTEIN: mucosal addressin cell adhesion molecule 1 [KO:K06779]
130580469  [KO:K06777] [EC:3.1.3.48]
130580535  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
130580562  CD226; LOW QUALITY PROTEIN: CD226 antigen [KO:K06567]
130580707  SDC4; syndecan-4 [KO:K16338]
130580937  NEO1; neogenin [KO:K06766]
130581035  ICOSLG; ICOS ligand [KO:K06710]
130581110  CADM1; cell adhesion molecule 1 [KO:K06781]
130581111  CLDN25; putative claudin-25 [KO:K06087]
130581437  CNTNAP1; contactin-associated protein 1 [KO:K07379]
130581515  CDH4; cadherin-4 [KO:K06797]
130581806  [KO:K06745]
130581809  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
130582130  NRXN3; neurexin 3 [KO:K07377]
130582241  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
130582282  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
130582788  CD8B; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD8 beta chain [KO:K06459]
130583008  [KO:K06787]
130583067  [KO:K06087]
130583068  CLDN19; claudin-19 [KO:K06087]
130583132  CLDN18; claudin-18 isoform X1 [KO:K06087]
130583232  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
130583282  [KO:K28137]
130583283  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
130583559  SELE; E-selectin [KO:K06494]
130583724  ITGA8; integrin alpha-8 [KO:K06584]
130583831  ITGAV; integrin alpha-V [KO:K06487]
130584331  CLDN1; claudin-1 [KO:K06087]
130584333  CLDN16; claudin-16 isoform X1 [KO:K06087]
130584435  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
130584755  CD40LG; CD40 ligand isoform X1 [KO:K03161]
130584825  OCLN; occludin [KO:K06088]
130584833  [KO:K06778] [EC:3.1.3.48]
130584844  NECTIN1; nectin-1 isoform X1 [KO:K06081]
130585011  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
130585375  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
130585768  CD276; CD276 antigen [KO:K06746]
130585839  [KO:K06793]
130585894  CDH15; cadherin-15 [KO:K06809]
130585916  CLDN34; claudin-34 [KO:K06087]
130585945  JAM3; junctional adhesion molecule C [KO:K06785]
130586268  [KO:K07523]
130586331  NFASC; neurofascin [KO:K06757]
130586431  CNTN2; contactin-2 [KO:K06760]
130586774  [KO:K06087]
130586775  [KO:K06087]
130586848  [KO:K05718]
130586931  SDC3; syndecan-3 [KO:K16337]
130587010  [KO:K06752]
130587251  CADM3; cell adhesion molecule 3 [KO:K06780]
130587298  [KO:K06752]
130587343  [KO:K06751]
130587344  [KO:K06751]
130587655  [KO:K16360]
130587791  [KO:K06751]
130587794  [KO:K06752]
130587795  [KO:K06752]
130587875  [KO:K06751]
130588048  [KO:K06751]
130588108  [KO:K06751]
130588149  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
130588434  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
130588442  [KO:K06752]
130588576  [KO:K06752]
130588593  [KO:K06752]
130588864  ITGB2; integrin beta-2 [KO:K06464]
130588900  CD2; T-cell surface antigen CD2 [KO:K06449]
130588925  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
130588936  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
130589210  SDC1; syndecan-1 [KO:K06257]
130589324  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
mmea04520  Adherens junction
mmea04530  Tight junction
KO pathway
ko04514   

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