KEGG PATHWAY: mmu04330

KEGG

PATHWAY: mmu04330

Entry

mmu04330                    Pathway

Name

Notch signaling pathway - Mus musculus (house mouse)

Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Class

Environmental Information Processing; Signal transduction

Pathway map

Notch signaling pathway

Other DBs

GO:

Organism

Mus musculus (house mouse) [GN:mmu]

Gene

Dll1; delta like canonical Notch ligand 1 [KO:K06051]

Dll3; delta like canonical Notch ligand 3 [KO:K06051]

Dll4; delta like canonical Notch ligand 4 [KO:K06051]

Jag1; jagged 1 [KO:K06052]

Jag2; jagged 2 [KO:K21635]

Lfng; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]

Mfng; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]

Rfng; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]

Notch1; notch 1 [KO:K02599]

Notch2; notch 2 [KO:K20994]

Notch3; notch 3 [KO:K20995]

Notch4; notch 4 [KO:K20996]

Rbpj; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]

Rbpjl; recombination signal binding protein for immunoglobulin kappa J region-like [KO:K06053]

Hes1; hes family bHLH transcription factor 1 [KO:K06054]

Hes5; hes family bHLH transcription factor 5 [KO:K06055]

Heyl; hairy/enhancer-of-split related with YRPW motif-like [KO:K09091]

Hey1; hairy/enhancer-of-split related with YRPW motif 1 [KO:K09091]

Hey2; hairy/enhancer-of-split related with YRPW motif 2 [KO:K09091]

Ptcra; pre T cell antigen receptor alpha [KO:K06056]

Nrarp; Notch-regulated ankyrin repeat protein [KO:K26480]

Dvl3; dishevelled segment polarity protein 3 [KO:K02353]

Dvl1; dishevelled segment polarity protein 1 [KO:K02353]

Dvl2; dishevelled segment polarity protein 2 [KO:K02353]

Numb; NUMB endocytic adaptor protein [KO:K06057]

Numbl; numb-like [KO:K06057]

Itch; itchy, E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]

Dtx1; deltex 1, E3 ubiquitin ligase [KO:K06058] [EC:2.3.2.27]

Dtx4; deltex 4, E3 ubiquitin ligase [KO:K06058] [EC:2.3.2.27]

Dtx3l; deltex 3-like, E3 ubiquitin ligase [KO:K06058] [EC:2.3.2.27]

Dtx2; deltex 2, E3 ubiquitin ligase [KO:K06058] [EC:2.3.2.27]

Dtx3; deltex 3, E3 ubiquitin ligase [KO:K06058] [EC:2.3.2.27]

Adam17; a disintegrin and metallopeptidase domain 17 [KO:K06059] [EC:3.4.24.86]

Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]

Psen2; presenilin 2 [KO:K04522] [EC:3.4.23.-]

Psenen; presenilin enhancer gamma secretase subunit [KO:K06170]

Ncstn; nicastrin [KO:K06171]

Aph1a; aph1 homolog A, gamma secretase subunit [KO:K06172]

Aph1c; aph1 homolog C, gamma secretase subunit [KO:K06172]

Aph1b; aph1 homolog B, gamma secretase subunit [KO:K06172]

Maml1; mastermind like transcriptional coactivator 1 [KO:K06061]

Maml3; mastermind like transcriptional coactivator 3 [KO:K06061]

Maml2; mastermind like transcriptional coactivator 2 [KO:K06061]

Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]

Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]

Kat2a; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]

Kat2b; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]

Snw1; SNW domain containing 1 [KO:K06063]

Ctbp1; C-terminal binding protein 1 [KO:K04496] [EC:1.1.1.428]

Ctbp2; C-terminal binding protein 2 [KO:K04496] [EC:1.1.1.428]

Tle7; TLE family member 7 [KO:K04497]

Tle6; transducin-like enhancer of split 6 [KO:K04497]

Tle1; transducin-like enhancer of split 1 [KO:K04497]

Tle2; transducin-like enhancer of split 2 [KO:K04497]

Tle3; transducin-like enhancer of split 3 [KO:K04497]

Tle4; transducin-like enhancer of split 4 [KO:K04497]

Ncor2; nuclear receptor co-repressor 2 [KO:K06065]

Cir1; corepressor interacting with RBPJ, 1 [KO:K06066]

Spen; spen family transcription repressor [KO:K25100]

Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]

Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]

Atxn1; ataxin 1 [KO:K23616]

Atxn1l; ataxin 1-like [KO:K23616]

Compound

Notch intracellular domain

Reference

Authors

Hansson EM, Lendahl U, Chapman G.

Title

Notch signaling in development and disease.

Journal

Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011

Reference

Authors

Callahan R, Egan SE.

Title

Notch signaling in mammary development and oncogenesis.

Journal

J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81

Reference

Authors

Zweidler-McKay PA, Pear WS.

Title

Notch and T cell malignancy.

Journal

Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012

Reference

Authors

Wu L, Griffin JD.

Title

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.

Journal

Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014

Reference

Authors

Tsukumo S, Yasutomo K.

Title

Notch governing mature T cell differentiation.

Journal

J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109

Reference

Authors

Haltiwanger RS.

Title

Regulation of signal transduction pathways in development by glycosylation.

Journal

Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8

Reference

Authors

Koo EH, Kopan R.

Title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Journal

Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065

Reference

Authors

Okano H, Imai T, Okabe M.

Title

Musashi: a translational regulator of cell fate.

Journal

J Cell Sci 115:1355-9 (2002)

Reference

Authors

Haltiwanger RS, Stanley P.

Title

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.

Journal

Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2

Reference

Authors

Das G, Reynolds-Kenneally J, Mlodzik M.

Title

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.

Journal

Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8

Reference

Authors

Cooper MT, Bray SJ.

Title

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.

Journal

Nature 397:526-30 (1999)
DOI:10.1038/17395

Reference

Authors

Tanigaki K, Kuroda K, Han H, Honjo T.

Title

Regulation of B cell development by Notch/RBP-J signaling.

Journal

Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3

Related
pathway

MAPK signaling pathway

KO pathway

LinkDB

DBGET integrated database retrieval system