KEGG   PATHWAY: nnt04530
Entry
nnt04530                    Pathway                                
Name
Tight junction - Nestor notabilis (Kea)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nnt04530  Tight junction
nnt04530

Other DBs
GO: 0005923
Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104398995  CLDN12; claudin-12 [KO:K06087]
104399401  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
104399500  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
104399807  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
104399938  [KO:K06087]
104400176  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104400344  [KO:K07901]
104400446  [KO:K04382] [EC:3.1.3.16]
104400509  JAM2; junctional adhesion molecule B [KO:K06735]
104400538  [KO:K05719]
104400577  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104400851  [KO:K04392]
104400973  [KO:K06448]
104400981  [KO:K04382] [EC:3.1.3.16]
104401036  [KO:K05692]
104401058  [KO:K07374]
104401186  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
104401209  [KO:K06099]
104401263  [KO:K12757]
104401428  JUN; transcription factor AP-1 [KO:K04448]
104401776  MLLT4; afadin isoform X1 [KO:K05702]
104401830  RHOA; transforming protein RhoA [KO:K04513]
104401877  [KO:K07200]
104401938  [KO:K06448]
104401981  [KO:K05757]
104402014  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104402183  [KO:K07374]
104402218  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
104402220  [KO:K05699]
104402339  [KO:K07374]
104402353  MSN; moesin isoform X1 [KO:K05763]
104402488  [KO:K12075]
104402494  AMOTL1; angiomotin-like protein 1 [KO:K06104]
104402613  [KO:K12757]
104402738  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
104402771  PRKAA2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104403105  SCRIB; protein scribble homolog [KO:K16175]
104403255  [KO:K05757]
104403309  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
104403342  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
104403689  [KO:K06087]
104403742  CLDN18; claudin-18 isoform X1 [KO:K06087]
104403821  [KO:K04514] [EC:2.7.11.39]
104403896  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
104404245  [KO:K13365]
104404284  [KO:K04354]
104404511  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104404589  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
104404865  AMOTL2; angiomotin-like protein 2 [KO:K06104]
104404868  ACTR3B; actin-related protein 3B [KO:K18584]
104405060  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104405243  [KO:K06088]
104405259  TJP3; LOW QUALITY PROTEIN: tight junction protein ZO-3 [KO:K06097]
104405546  [KO:K21099]
104405711  MPDZ; multiple PDZ domain protein [KO:K06095]
104405778  [KO:K05692]
104405784  [KO:K05762]
104405793  ACTR3; actin-related protein 3 [KO:K18584]
104406005  MICALL2; MICAL-like protein 2 [KO:K21068]
104406350  ARHGAP17; LOW QUALITY PROTEIN: rho GTPase-activating protein 17 [KO:K20638]
104406751  MYH9; myosin-9 isoform X1 [KO:K10352]
104406755  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
104406818  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104406820  MYH10; myosin-10 isoform X1 [KO:K10352]
104406853  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
104406878  EZR; ezrin isoform X1 [KO:K08007]
104407089  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
104407140  [KO:K06106]
104407533  TJP1; tight junction protein ZO-1 [KO:K05701]
104407538  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104407626  GATA4; transcription factor GATA-4 [KO:K09183]
104407663  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
104407883  CLDN2; claudin-2 [KO:K06087]
104407970  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104408146  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104408173  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
104408181  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
104408218  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
104408220  JAM3; junctional adhesion molecule C [KO:K06785]
104408311  [KO:K07374]
104408312  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104408678  [KO:K06087]
104408873  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
104409579  RAP2C; ras-related protein Rap-2c [KO:K07839]
104409589  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
104409667  CLDN11; claudin-11 [KO:K06087]
104409697  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104409728  [KO:K06093]
104409760  NF2; merlin isoform X1 [KO:K16684]
104409789  [KO:K04345] [EC:2.7.11.11]
104409793  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
104409840  PCNA; proliferating cell nuclear antigen [KO:K04802]
104409889  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
104410007  RAP1A; ras-related protein Rap-1A [KO:K04353]
104410114  CLDN14; claudin-14 [KO:K06087]
104410221  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104410334  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104410406  [KO:K16684]
104410426  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104410686  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
104410884  CLDN16; claudin-16 [KO:K06087]
104410964  CGNL1; LOW QUALITY PROTEIN: cingulin-like protein 1 [KO:K21110]
104411101  INADL; inaD-like protein [KO:K06092]
104411558  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104411573  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
104411726  RAPGEF6; rap guanine nucleotide exchange factor 6 [KO:K08020]
104411999  [KO:K06087]
104412000  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104412001  [KO:K06087]
104412117  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
104412129  CLDN23; LOW QUALITY PROTEIN: claudin-23 [KO:K06087]
104412132  [KO:K12076]
104412374  [KO:K06087]
104412402  CLDN20; claudin-20 [KO:K06087]
104412453  [KO:K10591] [EC:2.3.2.26]
104412686  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
104412697  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
104412979  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104412995  CTTN; LOW QUALITY PROTEIN: src substrate cortactin [KO:K06106]
104413098  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
104413173  [KO:K06087]
104413507  BVES; blood vessel epicardial substance [KO:K21108]
104413562  [KO:K06087]
104413563  CLDN19; claudin-19 [KO:K06087]
104413598  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104413690  CLDN1; claudin-1 [KO:K06087]
104413713  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
104413802  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
nnt04520  Adherens junction
nnt04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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