KEGG   PATHWAY: npd04150
Entry
npd04150                    Pathway                                
Name
mTOR signaling pathway - Nothoprocta perdicaria (Chilean tinamou)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
npd04150  mTOR signaling pathway
npd04150

Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942322  WNT2; protein Wnt-2 [KO:K00182]
112942696  [KO:K02649]
112942802  WNT6; protein Wnt-6 [KO:K00445]
112943138  WNT10A; protein Wnt-10a [KO:K01357]
112943199  WDR59; GATOR complex protein WDR59 [KO:K20409]
112943411  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
112943469  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112943529  HRAS; GTPase HRas [KO:K02833]
112943556  PRR5L; proline-rich protein 5-like [KO:K20411]
112943692  FZD4; frizzled-4 [KO:K02354]
112943851  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
112943951  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112944059  WNT5A; protein Wnt-5a [KO:K00444]
112944621  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
112944633  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
112944752  MIOS; GATOR complex protein MIOS [KO:K20407]
112945237  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112945254  INS; insulin [KO:K04526]
112945291  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
112945473  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
112945478  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
112945628  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112945699  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
112945860  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
112945930  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112945940  FZD10; frizzled-10 [KO:K02842]
112946009  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112946117  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
112946216  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
112946390  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
112946590  RRAGD; ras-related GTP-binding protein D [KO:K16186]
112946628  IGF1; insulin-like growth factor I [KO:K05459]
112946923  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112947054  [KO:K16185]
112947317  FZD1; frizzled-1 [KO:K02432]
112947867  IRS1; insulin receptor substrate 1 [KO:K16172]
112947888  CAB39; calcium-binding protein 39 [KO:K08272]
112947911  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112947974  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
112948225  SEH1L; nucleoporin SEH1 [KO:K14299]
112948263  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112948275  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112948417  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112948431  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112948498  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
112948692  WNT11; protein Wnt-11 [KO:K01384]
112948774  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112948904  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
112948943  FZD3; frizzled-3 [KO:K02329]
112949088  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112949311  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
112949417  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
112949531  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
112949723  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
112949808  [KO:K20402]
112949856  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
112950301  WNT1; proto-oncogene Wnt-1 [KO:K03209]
112950390  [KO:K02147]
112950438  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
112950669  KRAS; GTPase KRas [KO:K07827]
112950709  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
112950735  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
112950756  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112950772  [KO:K20394]
112951058  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112951073  FZD2; frizzled-2 [KO:K02235]
112951088  WNT9B; protein Wnt-9b [KO:K01064]
112951230  RPS6; 40S ribosomal protein S6 [KO:K02991]
112951247  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
112951487  NRAS; GTPase NRas [KO:K07828]
112951968  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112951999  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
112952005  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
112952135  [KO:K00312]
112952136  WNT9A; protein Wnt-9a [KO:K01064]
112952220  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
112952529  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
112952543  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
112952569  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112952674  FNIP1; folliculin-interacting protein 1 [KO:K20400]
112953017  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112953079  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
112953102  WNT7A; protein Wnt-7a [KO:K00572]
112953302  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
112953407  RHOA; transforming protein RhoA [KO:K04513]
112953575  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
112953666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112953760  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112953853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112953894  TBC1D7; TBC1 domain family member 7 [KO:K20396]
112954370  WNT8A; protein Wnt-8a [KO:K00714]
112954414  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
112954566  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112954698  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
112954702  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
112954908  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
112955229  [KO:K02145] [EC:7.1.2.2]
112955244  SOS1; son of sevenless homolog 1 [KO:K03099]
112955323  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
112955351  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955401  FZD5; frizzled-5 [KO:K02375]
112955436  FZD8; frizzled-8 [KO:K02375]
112955491  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955541  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
112955629  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
112955662  WDR24; GATOR complex protein WDR24 [KO:K20408]
112955817  TSC1; hamartin [KO:K07206]
112955853  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
112955878  FZD7; frizzled-7 [KO:K02432]
112955959  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
112956572  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
112956685  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
112956743  FZD9; frizzled-9 [KO:K02842]
112956862  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
112956870  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
112956874  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
112956891  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112956980  WNT8B; protein Wnt-8b [KO:K00714]
112957312  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112957346  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
112957373  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112957576  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112957763  SOS2; son of sevenless homolog 2 [KO:K03099]
112957835  FZD6; frizzled-6 [KO:K02376]
112957836  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
112957922  WNT16; protein Wnt-16 [KO:K01558]
112958103  RHEB; GTP-binding protein Rheb [KO:K07208]
112958156  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112958318  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
112958352  WNT5B; protein Wnt-5b [KO:K00444]
112958642  SEC13; protein SEC13 homolog [KO:K14004]
112959326  CAB39L; calcium-binding protein 39-like [KO:K08272]
112959567  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112959596  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112959758  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112959892  TSC2; tuberin isoform X1 [KO:K07207]
112959897  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112959904  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
112960070  FLCN; folliculin [KO:K09594]
112960086  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
112960097  [KO:K00408]
112960293  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
112960385  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
112960399  [KO:K01384]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
npd00561  Glycerolipid metabolism
npd04010  MAPK signaling pathway
npd04140  Autophagy - animal
npd04810  Regulation of actin cytoskeleton
npd04910  Insulin signaling pathway
KO pathway
ko04150   

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