KEGG   PATHWAY: ola00564
Entry
ola00564                    Pathway                                
Name
Glycerophospholipid metabolism - Oryzias latipes (Japanese medaka)
Class
Metabolism; Lipid metabolism
Pathway map
ola00564  Glycerophospholipid metabolism
ola00564

Module
ola_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ola00564]
ola_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ola00564]
Other DBs
GO: 0006650
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101155171  glycerol-3-phosphate dehydrogenase 1-like protein isoform X2 [KO:K00006] [EC:1.1.1.8]
101158855  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
101154943  gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
101167020  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
101156981  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
101174228  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
101167873  glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
101171838  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
101157182  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
101163833  glycerol-3-phosphate acyltransferase 4-like isoform X1 [KO:K13506] [EC:2.3.1.15]
101159762  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
101156844  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101155591  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101168733  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101155556  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101157881  mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101170063  mboat2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101155817  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
101166180  dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
105356600  LOW QUALITY PROTEIN: manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
111946384  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101168661  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101172508  plpp1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101173452  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
101166135  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101159828  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101171943  phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
101156966  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101166433  lpin1; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
101174419  phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
101161835  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101158806  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
101171318  phosphatidate phosphatase LPIN1 isoform X4 [KO:K15728] [EC:3.1.3.4]
101174194  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101173574  plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101154951  diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
101171163  dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101157668  dgke; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
101168014  dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101165102  diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
101165925  diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
101159850  dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
101165301  diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
105356367  diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
101166178  diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
101173516  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
101175604  samd8; sphingomyelin synthase-related protein 1 [KO:K22697] [EC:3.1.4.62]
101167981  sphingomyelin synthase-related protein 1 [KO:K22697] [EC:3.1.4.62]
101173002  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101170793  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101172470  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
101155216  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
101175514  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101166915  pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101162058  phospholipase D3 [KO:K16860] [EC:3.1.4.4]
101174475  pld4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
101159515  phospholipase D3-like isoform X1 [KO:K16860] [EC:3.1.4.4]
101172491  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
101175621  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
101173712  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101170929  phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101155667  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101156220  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101162698  proca1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
101162393  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
105355175  group 3 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
101172400  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101156151  pla2g4c; cytosolic phospholipase A2 gamma isoform X2 [KO:K16342] [EC:3.1.1.4]
101160628  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101164444  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105357244  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101157546  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101173355  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101169090  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101168683  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101159130  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101172965  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101161012  lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101154975  lpcat3; lysophospholipid acyltransferase 5 isoform X2 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101160201  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
101172239  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
101170197  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
101159830  patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
101172993  patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
101155983  neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
101160778  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
101156191  choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
101173179  choline O-acetyltransferase isoform X2 [KO:K00623] [EC:2.3.1.6]
101161586  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
101159912  choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101161031  choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101167458  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
101155150  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
101162151  choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
101157809  pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
101166014  pcyt1b; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
101163703  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
101173857  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
101175315  ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101174551  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101172414  ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
101171141  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
101161165  phosphoethanolamine N-methyltransferase isoform X1 [KO:K05929] [EC:2.1.1.103]
101168404  etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
101157624  phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
101161564  phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
101169888  pla1a; phospholipase A1 member A isoform X3 [KO:K13618] [EC:3.1.1.111]
101161577  phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
101161656  phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
101164977  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
101173995  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
101171364  pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X2 [KO:K00995] [EC:2.7.8.5]
101168482  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
101157519  taz; tafazzin [KO:K13511] [EC:2.3.1.-]
101168169  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
101167290  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
101161994  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
ola00010  Glycolysis / Gluconeogenesis
ola00260  Glycine, serine and threonine metabolism
ola00561  Glycerolipid metabolism
ola00562  Inositol phosphate metabolism
ola00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ola00565  Ether lipid metabolism
ola00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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