KEGG   PATHWAY: ola00830
Entry
ola00830                    Pathway                                
Name
Retinol metabolism - Oryzias latipes (Japanese medaka)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ola00830  Retinol metabolism
ola00830

Other DBs
GO: 0006776
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
100125487  beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
100125495  beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
100049398  adh5; class III alcohol dehydrogenase, chi subunit [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100049415  adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101172385  alcohol dehydrogenase 1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101172875  alcohol dehydrogenase 1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
101159580  dhrs3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
101171443  dhrs4; dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
101169911  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
101168360  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
101157056  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
101162684  retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
101170667  retinol dehydrogenase 10-A isoform X1 [KO:K11151] [EC:1.1.1.-]
101173817  rdh10; retinol dehydrogenase 10 isoform X1 [KO:K11151] [EC:1.1.1.-]
101164605  retinol dehydrogenase 12 isoform X1 [KO:K11153] [EC:1.1.1.300]
101171076  retinol dehydrogenase 13 [KO:K11153] [EC:1.1.1.300]
101168330  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
101167436  retinol dehydrogenase 12-like isoform X1 [KO:K11153] [EC:1.1.1.300]
101164264  retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
111946613  retinol dehydrogenase 12-like isoform X1 [KO:K11153] [EC:1.1.1.300]
101164512  rdh13; retinol dehydrogenase 13 isoform X1 [KO:K11161] [EC:1.1.1.300]
101174946  sdr16c5; epidermal retinol dehydrogenase 2 isoform X1 [KO:K15734] [EC:1.1.1.105]
101162811  lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
101158747  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
101172026  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
105356312  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
101166984  diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
101155899  diacylglycerol O-acyltransferase 1 isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
101163729  retinal Mueller cells isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
101172024  rpe65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
100125503  rdh5; 11-cis retinol dehydrogenase [KO:K00061] [EC:1.1.1.315]
101168436  aox1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100049450  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
101156925  cyp26a1; cytochrome P450, family 26, subfamily A, polypeptide 1 [KO:K07437] [EC:1.14.14.-]
101159703  cyp26b1; cytochrome P450, family 26, subfamily B, polypeptide 1 [KO:K12664] [EC:1.14.14.-]
101163759  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
101155293  cytochrome P450 3A56 [KO:K07424] [EC:1.14.14.1]
101155538  cytochrome P450 3A30 [KO:K07424] [EC:1.14.14.1]
100125817  cyp3a40; cytochrome P450 3A40 [KO:K07424] [EC:1.14.14.1]
101155406  cyp3a; cytochrome P450, family 3, subfamily A [KO:K07424] [EC:1.14.14.1]
101172907  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
101159946  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
100125518  UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
101168388  UDP-glucuronosyltransferase 1-5 [KO:K00699] [EC:2.4.1.17]
101170116  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
100125517  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
101175367  UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
101173361  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
101165182  UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
110013324  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
101160151  UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
101155933  retsat; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
101173846  putative all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
101162403  putative all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
101157281  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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