KEGG   PATHWAY: omc00830
Entry
omc00830                    Pathway                                
Name
Retinol metabolism - Onychostoma macrolepis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
omc00830  Retinol metabolism
omc00830

Other DBs
GO: 0006776
Organism
Onychostoma macrolepis [GN:omc]
Gene
131543254  bco1l; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
131544153  bco1; LOW QUALITY PROTEIN: beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
131551802  adh8a; alcohol dehydrogenase 8a [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131551803  alcohol dehydrogenase 1-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131553172  zgc:77938; alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131553173  adh5l; alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131553447  adh5; alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131531510  dhrs3a; short-chain dehydrogenase/reductase 3a [KO:K11146] [EC:1.1.1.300]
131548900  dhrs3b; short-chain dehydrogenase/reductase 3b isoform X1 [KO:K11146] [EC:1.1.1.300]
131544313  dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
131542485  zgc:109982; retinol dehydrogenase 8 isoform X1 [KO:K11150] [EC:1.1.1.-]
131545466  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
131545476  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
131549473  retinol dehydrogenase 10-like [KO:K11151] [EC:1.1.1.-]
131533589  rdh10a; retinol dehydrogenase 10-A [KO:K11151] [EC:1.1.1.-]
131542926  rdh20; LOW QUALITY PROTEIN: retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
131526580  rdh10b; retinol dehydrogenase 10-B [KO:K11151] [EC:1.1.1.-]
131532846  si:dkey-73n8.3; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
131533179  zgc:112332; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
131533528  rdh12l; retinol dehydrogenase 12, like [KO:K11153] [EC:1.1.1.300]
131525581  zgc:153441; retinol-DH_like_SDR_c domain-containing protein isoform X1 [KO:K11153] [EC:1.1.1.300]
131543393  retinol dehydrogenase 11-like [KO:K11153] [EC:1.1.1.300]
131543923  retinol dehydrogenase 11-like [KO:K11153] [EC:1.1.1.300]
131543924  retinol dehydrogenase 11-like [KO:K11153] [EC:1.1.1.300]
131552077  rdh12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
131521551  si:dkey-23o4.6; retinol dehydrogenase 13 isoform X1 [KO:K11153] [EC:1.1.1.300]
131528856  si:dkey-94e7.2; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
131527357  si:dkey-221h15.4; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
131544991  sdr16c5b; epidermal retinol dehydrogenase 2 isoform X1 [KO:K15734] [EC:1.1.1.105]
131548138  lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
131548148  lratb.2; lecithin retinol acyltransferase b, tandem duplicate 2 [KO:K00678] [EC:2.3.1.135]
131549657  lrata; lecithin retinol acyltransferase a [KO:K00678] [EC:2.3.1.135]
131543983  si:dkey-30k22.5; LOW QUALITY PROTEIN: lecithin retinol acyltransferase family protein [KO:K00678] [EC:2.3.1.135]
131526337  dgat1a; diacylglycerol O-acyltransferase 1a [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
131522422  dgat1b; diacylglycerol O-acyltransferase 1b isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
131546696  pnpla4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
131527276  rpe65a; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
131545344  retinal Mueller cells isomerohydrolase isoform X1 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
131531002  rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
131529641  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
131529646  aox6; aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
131544375  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
131545025  aldh1a3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
131551059  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
131544638  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
131523205  LOW QUALITY PROTEIN: cytochrome P450 26B1 [KO:K12665] [EC:1.14.14.-]
131536899  cytochrome P450 3A30-like [KO:K07424] [EC:1.14.14.1]
131538018  cytochrome P450 3A30-like isoform X1 [KO:K07424] [EC:1.14.14.1]
131540589  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131540591  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131541076  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
131541436  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
131548408  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 isoform X1 [KO:K00699] [EC:2.4.1.17]
131524118  ugt5f1; UDP glucuronosyltransferase 5 family, polypeptide F1 [KO:K00699] [EC:2.4.1.17]
131548805  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 isoform X1 [KO:K00699] [EC:2.4.1.17]
131548924  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131548927  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
131548929  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
131532995  UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
131534667  ugt5a2; UDP glucuronosyltransferase 5 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
131534668  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
131534669  ugt5a5; UDP glucuronosyltransferase 5 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
131535841  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131535864  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
131535873  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131544101  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 [KO:K00699] [EC:2.4.1.17]
131545221  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 [KO:K00699] [EC:2.4.1.17]
131546878  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131546880  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131546904  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131546905  UDP-glucuronosyltransferase 1A5-like [KO:K00699] [EC:2.4.1.17]
131540390  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131550568  si:ch1073-13h15.3; inactive all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
131536306  all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
131546454  retsatl; inactive all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
131542389  cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

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