KEGG   PATHWAY: aamp03083
Entry
aamp03083                   Pathway                                
Name
Polycomb repressive complex - Arvicola amphibius (Eurasian water vole)
Class
Genetic Information Processing; Chromosome
Pathway map
aamp03083  Polycomb repressive complex
aamp03083

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119811825  Ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
119807752  Ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
119802589  Eed; polycomb protein EED isoform X1 [KO:K11462]
119812928  Suz12; polycomb protein SUZ12 [KO:K11463]
119816889  Rbbp4; histone-binding protein RBBP4 [KO:K10752]
119819492  LOW QUALITY PROTEIN: histone-binding protein RBBP4-like [KO:K10752]
119804761  Rbbp7; histone-binding protein RBBP7 [KO:K11659]
119823561  Phf1; PHD finger protein 1 isoform X1 [KO:K11467]
119807637  Mtf2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
119818976  Phf19; PHD finger protein 19 [KO:K11486]
119813172  elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
119804999  Lcor; ligand-dependent corepressor isoform X1 [KO:K26260]
119806911  Aebp2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
119817722  Jarid2; protein Jumonji [KO:K11478]
119827394  Bap1; ubiquitin carboxyl-terminal hydrolase BAP1 [KO:K08588] [EC:3.4.19.12]
119814774  Asxl1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
119815776  Asxl3; putative Polycomb group protein ASXL3 [KO:K11471]
119806947  Asxl2; putative Polycomb group protein ASXL2 [KO:K11471]
119804580  Ogt; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
119804797  Hcfc1; host cell factor 1 isoform X1 [KO:K14966]
119818504  Yy1; transcriptional repressor protein YY1 [KO:K09201]
119804852  Yy2; transcription factor YY2 [KO:K09201]
119818380  Mbd5; methyl-CpG-binding domain protein 5 [KO:K23219]
119803280  Mbd6; LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 6 [KO:K26585]
119825066  Foxk1; forkhead box protein K1 [KO:K09404]
119812522  Foxk2; forkhead box protein K2 isoform X1 [KO:K09404]
119823042  Ring1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
119810603  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
119810606  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
119810607  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
119810608  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
119810609  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
119827456  Rnf2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
119813371  Pcgf2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
119816341  Bmi1; LOW QUALITY PROTEIN: polycomb complex protein BMI-1 [KO:K11459]
119813573  Cbx2; chromobox protein homolog 2 [KO:K11451]
119813134  Cbx4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
119822739  Cbx6; chromobox protein homolog 6 [KO:K11453]
119823942  Cbx7; chromobox protein homolog 7 isoform X1 [KO:K11454]
119813135  Cbx8; chromobox protein homolog 8 [KO:K11455]
119806712  Phc1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
119817023  Phc2; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
119826115  Phc3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
119805139  Scml2; sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
119817336  Scmh1; polycomb protein SCMH1 isoform X1 [KO:K11461]
119816559  Sfmbt2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
119827221  Sfmbt1; scm-like with four MBT domains protein 1 [KO:K26269]
119812619  Aurkb; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
119805129  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
119800615  Ube2d3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
119814302  Ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
119823557  Ube2d1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
119814116  Ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
119820685  ubiquitin-conjugating enzyme E2 D2B [KO:K06689] [EC:2.3.2.23]
119805473  ubiquitin-conjugating enzyme E2 2-like [KO:K06689] [EC:2.3.2.23]
119824685  Usp16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
119826521  Usp45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
119807982  RING1 and YY1-binding protein isoform X1 [KO:K11469]
119822915  Yaf2; YY1-associated factor 2 [KO:K11468]
119807065  Pcgf1; polycomb group RING finger protein 1 [KO:K11487]
119825697  Kdm2b; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
119812921  Kdm2a; LOW QUALITY PROTEIN: lysine-specific demethylase 2A [KO:K10276] [EC:1.14.11.27]
119805143  Bcor; BCL-6 corepressor isoform X1 [KO:K23215]
119805136  Bcorl1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
119812769  Skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
119820564  S-phase kinase-associated protein 1 [KO:K03094]
119811912  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
119825801  Pcgf3; polycomb group RING finger protein 3 [KO:K11488]
119811936  Pcgf5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
119822509  Csnk2b; casein kinase II subunit beta [KO:K03115]
119825405  Auts2; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
119812286  Fbrs; probable fibrosin-1 [KO:K26253]
119825290  Fbrsl1; fibrosin-1-like protein isoform X1 [KO:K26254]
119811736  Dcaf7; DDB1- and CUL4-associated factor 7 [KO:K11805]
119826503  Tex10; testis-expressed protein 10 isoform X1 [KO:K14827]
119822927  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
119811558  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
119822622  Pcgf6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
119804800  polycomb group RING finger protein 6-like [KO:K11470]
119808114  E2f6; transcription factor E2F6 [KO:K09390]
119811297  Tfdp1; transcription factor Dp-1 isoform X1 [KO:K04683]
119825996  protein max-like [KO:K04453]
119805389  LOW QUALITY PROTEIN: protein max-like [KO:K04453]
119820001  Max; protein max isoform X1 [KO:K04453]
119814187  Mga; MAX gene-associated protein isoform X1 [KO:K23399]
119814745  L3mbtl1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
119823206  L3mbtl2; lethal(3)malignant brain tumor-like protein 2 [KO:K24387]
119820603  L3mbtl3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
119808456  Cbx3; chromobox protein homolog 3 isoform X1 [KO:K11586]
119814833  chromobox protein homolog 3 [KO:K11586]
119820554  chromobox protein homolog 3-like [KO:K11586]
119824998  WD repeat-containing protein 5B [KO:K14963]
119825106  WD repeat-containing protein 5B-like [KO:K14963]
119819043  Wdr5; WD repeat-containing protein 5 [KO:K14963]
119820755  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
119816884  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
119820706  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
119820797  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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