KEGG   PATHWAY: adu00270
Entry
adu00270                    Pathway                                
Name
Cysteine and methionine metabolism - Arachis duranensis
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
adu00270  Cysteine and methionine metabolism
adu00270

Module
adu_M00021  Cysteine biosynthesis, serine => cysteine [PATH:adu00270]
adu_M00034  Methionine salvage pathway [PATH:adu00270]
adu_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:adu00270]
Other DBs
GO: 0006534 0006555
Organism
Arachis duranensis [GN:adu]
Gene
107477913  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
107472955  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
107487415  serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
107458714  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
107490183  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
107462533  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
107496188  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
127747578  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
107488539  cysteine synthase [KO:K01738] [EC:2.5.1.47]
107465606  putative inactive cysteine synthase 2 isoform X2 [KO:K01738] [EC:2.5.1.47]
107465607  cysteine synthase [KO:K01738] [EC:2.5.1.47]
107480885  cysteine synthase, chloroplastic/chromoplastic [KO:K01738] [EC:2.5.1.47]
107489167  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
107496111  LOW QUALITY PROTEIN: cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
107472470  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
107485772  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
107492679  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
107493005  selenocysteine methyltransferase [KO:K00547] [EC:2.1.1.10]
107467014  homocysteine S-methyltransferase 3 [KO:K00547] [EC:2.1.1.10]
107494407  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
107471949  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
107493585  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
107495899  S-adenosylmethionine synthase 3-like [KO:K00789] [EC:2.5.1.6]
107495906  S-adenosylmethionine synthase 3-like [KO:K00789] [EC:2.5.1.6]
107492339  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
107470141  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
107492228  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
107465162  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
107482600  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
107486533  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107477094  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107491249  LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
127743874  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
107481310  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
107488767  spermidine synthase [KO:K00797] [EC:2.5.1.16]
107460615  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
107491055  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
107465178  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
107492163  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
107459596  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
107460479  5'-methylthioadenosine nucleosidase [KO:K01244] [EC:3.2.2.16]
107467343  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
107467567  methylthioribose kinase-like isoform X1 [KO:K00899] [EC:2.7.1.100]
107488058  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
107463016  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
107462602  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
107463660  acireductone dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107467053  acireductone dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107467062  acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107460784  uncharacterized protein LOC107460784 [KO:K23977] [EC:2.6.1.117]
107463070  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107478096  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107462233  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
107478521  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107463784  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
107465931  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
107482373  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
107490321  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
107479097  LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase CMT2 [KO:K00558] [EC:2.1.1.37]
107489734  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
107487420  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
107492131  PWWP domain-containing protein 1 [KO:K17398] [EC:2.1.1.37]
107482295  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
107482804  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
107479870  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
107485807  1-aminocyclopropane-1-carboxylate synthase 1-like [KO:K20772] [EC:4.4.1.14]
107472766  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
107488156  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
107479619  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
107487560  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
107482547  1-aminocyclopropane-1-carboxylate synthase CMA101-like [KO:K01762] [EC:4.4.1.14]
107490118  LOW QUALITY PROTEIN: 1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
107461133  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
107466373  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107460718  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
107496871  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
107496872  LOW QUALITY PROTEIN: 1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
107496874  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107482960  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107490141  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
107494643  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
107482303  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107481439  uncharacterized protein LOC107481439 [KO:K00133] [EC:1.2.1.11]
107471195  LOW QUALITY PROTEIN: cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
107486697  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
107461220  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
107480547  branched-chain-amino-acid aminotransferase 6 [KO:K00826] [EC:2.6.1.42]
107480548  branched-chain-amino-acid aminotransferase 6-like [KO:K00826] [EC:2.6.1.42]
107487611  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
107480597  putative branched-chain-amino-acid aminotransferase 7 isoform X1 [KO:K00826] [EC:2.6.1.42]
107475434  LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107480413  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107473704  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107485208  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107479947  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107491811  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107470766  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
107475439  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
107478019  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
107495431  aspartate aminotransferase P2, mitochondrial [KO:K00811] [EC:2.6.1.1]
107458633  thiosulfate/3-mercaptopyruvate sulfurtransferase 2 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107488116  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
107485794  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
107474401  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial [KO:K05396] [EC:4.4.1.15]
107469008  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
107492236  LOW QUALITY PROTEIN: probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
107465010  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
107465126  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
107466182  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
107466183  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
107473168  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
107468336  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
107480540  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
107487600  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
107478388  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
107468023  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
107494302  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic isoform X1 [KO:K22846] [EC:2.5.1.144]
107459550  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107467304  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107482499  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107487412  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
adu00010  Glycolysis / Gluconeogenesis
adu00250  Alanine, aspartate and glutamate metabolism
adu00260  Glycine, serine and threonine metabolism
adu00290  Valine, leucine and isoleucine biosynthesis
adu00430  Taurine and hypotaurine metabolism
adu00480  Glutathione metabolism
adu00620  Pyruvate metabolism
adu00640  Propanoate metabolism
adu00770  Pantothenate and CoA biosynthesis
adu00900  Terpenoid backbone biosynthesis
adu00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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