KEGG   PATHWAY: ahf00900
Entry
ahf00900                    Pathway                                
Name
Terpenoid backbone biosynthesis - Arachis hypogaea (peanut)
Description
Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ahf00900  Terpenoid backbone biosynthesis
ahf00900

Module
ahf_M00095  C5 isoprenoid biosynthesis, mevalonate pathway [PATH:ahf00900]
ahf_M00096  C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:ahf00900]
ahf_M00366  C10-C20 isoprenoid biosynthesis, plants [PATH:ahf00900]
Other DBs
GO: 0009240 0016091
Organism
Arachis hypogaea (peanut) [GN:ahf]
Gene
112769180  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
112733825  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
112791719  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
112698705  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
112757059  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
112704968  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
112723032  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
112723520  probable 1-deoxy-D-xylulose-5-phosphate synthase 2, chloroplastic [KO:K01662] [EC:2.2.1.7]
112741103  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
112707858  probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic [KO:K01662] [EC:2.2.1.7]
112710318  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic [KO:K00099] [EC:1.1.1.267]
112695470  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic [KO:K00099] [EC:1.1.1.267]
112775209  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic [KO:K00099] [EC:1.1.1.267]
112722349  1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic [KO:K00099] [EC:1.1.1.267]
112722754  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic [KO:K00991] [EC:2.7.7.60]
112722760  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic [KO:K00991] [EC:2.7.7.60]
112706805  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic [KO:K00991] [EC:2.7.7.60]
112705796  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic isoform X1 [KO:K00919] [EC:2.7.1.148]
112764815  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic [KO:K00919] [EC:2.7.1.148]
112749685  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic [KO:K01770] [EC:4.6.1.12]
112801453  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic [KO:K01770] [EC:4.6.1.12]
112786104  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic [KO:K03526] [EC:1.17.7.1 1.17.7.3]
112769151  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic [KO:K03526] [EC:1.17.7.1 1.17.7.3]
112736519  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic [KO:K03526] [EC:1.17.7.1 1.17.7.3]
112706788  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic [KO:K03526] [EC:1.17.7.1 1.17.7.3]
112788940  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic [KO:K03527] [EC:1.17.7.4]
112736848  4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic [KO:K03527] [EC:1.17.7.4]
112732345  probable acetyl-CoA acetyltransferase, cytosolic 2 isoform X1 [KO:K00626] [EC:2.3.1.9]
112750545  uncharacterized protein LOC112750545 isoform X1 [KO:K00626] [EC:2.3.1.9]
112722800  acetyl-CoA acetyltransferase, cytosolic 1 [KO:K00626] [EC:2.3.1.9]
112706491  probable acetyl-CoA acetyltransferase, cytosolic 2 [KO:K00626] [EC:2.3.1.9]
112764736  acetyl-CoA acetyltransferase, cytosolic 1 [KO:K00626] [EC:2.3.1.9]
112764757  acetyl-CoA acetyltransferase, cytosolic 1 isoform X1 [KO:K00626] [EC:2.3.1.9]
112802772  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
112803982  hydroxymethylglutaryl-CoA synthase isoform X1 [KO:K01641] [EC:2.3.3.10]
112749547  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
112751702  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
112722170  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
112800840  hydroxymethylglutaryl-CoA synthase [KO:K01641] [EC:2.3.3.10]
112766610  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [KO:K00021] [EC:1.1.1.34]
112786654  3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 [KO:K00021] [EC:1.1.1.34]
112747624  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
112702186  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [KO:K00021] [EC:1.1.1.34]
112797557  3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 [KO:K00021] [EC:1.1.1.34]
112800231  3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [KO:K00021] [EC:1.1.1.34]
112755499  mevalonate kinase isoform X1 [KO:K00869] [EC:2.7.1.36]
112755643  mevalonate kinase isoform X1 [KO:K00869] [EC:2.7.1.36]
112756760  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
112712989  phosphomevalonate kinase, peroxisomal-like [KO:K00938] [EC:2.7.4.2]
112776386  phosphomevalonate kinase, peroxisomal-like [KO:K00938] [EC:2.7.4.2]
112702714  uncharacterized protein LOC112702714 [KO:K00938] [EC:2.7.4.2]
112737715  phosphomevalonate kinase, peroxisomal [KO:K00938] [EC:2.7.4.2]
112705925  phosphomevalonate kinase, peroxisomal [KO:K00938] [EC:2.7.4.2]
112764121  phosphomevalonate kinase, peroxisomal [KO:K00938] [EC:2.7.4.2]
112784999  phosphomevalonate kinase, peroxisomal-like [KO:K00938] [EC:2.7.4.2]
112712159  diphosphomevalonate decarboxylase MVD2, peroxisomal [KO:K01597] [EC:4.1.1.33]
112779924  diphosphomevalonate decarboxylase MVD2, peroxisomal [KO:K01597] [EC:4.1.1.33]
112750238  isopentenyl phosphate kinase isoform X1 [KO:K06981] [EC:2.7.4.26]
112801549  isopentenyl phosphate kinase [KO:K06981] [EC:2.7.4.26]
112797569  isopentenyl-diphosphate Delta-isomerase I [KO:K01823] [EC:5.3.3.2]
112744261  isopentenyl-diphosphate Delta-isomerase I [KO:K01823] [EC:5.3.3.2]
112796068  farnesyl pyrophosphate synthase 1 isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
112741356  farnesyl pyrophosphate synthase 1 isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
112715297  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial [KO:K14066] [EC:2.5.1.1]
112706048  solanesyl-diphosphate synthase 1, mitochondrial [KO:K14066] [EC:2.5.1.1]
112784083  solanesyl diphosphate synthase 3, chloroplastic/mitochondrial [KO:K14066] [EC:2.5.1.1]
112766148  solanesyl-diphosphate synthase 1, mitochondrial isoform X1 [KO:K14066] [EC:2.5.1.1]
112745300  geranylgeranyl pyrophosphate synthase, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112748962  geranylgeranyl pyrophosphate synthase, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112792491  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112734719  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112701951  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112800661  geranylgeranyl pyrophosphate synthase, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112727601  geranylgeranyl pyrophosphate synthase, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112765596  heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic [KO:K13789] [EC:2.5.1.1 2.5.1.10 2.5.1.29]
112771865  probable solanesyl-diphosphate synthase 3, chloroplastic [KO:K05356] [EC:2.5.1.84 2.5.1.85]
112703489  probable solanesyl-diphosphate synthase 3, chloroplastic [KO:K05356] [EC:2.5.1.84 2.5.1.85]
112766898  dehydrodolichyl diphosphate synthase 2 isoform X1 [KO:K11778] [EC:2.5.1.87]
112709070  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112803392  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112729782  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112790464  dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1 [KO:K11778] [EC:2.5.1.87]
112749822  dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1 [KO:K11778] [EC:2.5.1.87]
112772048  dehydrodolichyl diphosphate synthase 6 [KO:K11778] [EC:2.5.1.87]
112701586  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112717740  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112797180  dehydrodolichyl diphosphate synthase 6 [KO:K11778] [EC:2.5.1.87]
112702882  dehydrodolichyl diphosphate synthase 2 isoform X1 [KO:K11778] [EC:2.5.1.87]
112721979  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112783128  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112723826  dehydrodolichyl diphosphate synthase 6-like [KO:K11778] [EC:2.5.1.87]
112764722  dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1 [KO:K11778] [EC:2.5.1.87]
112707716  dehydrodolichyl diphosphate synthase 6 [KO:K11778] [EC:2.5.1.87]
112710187  geranylgeranyl diphosphate reductase, chloroplastic [KO:K10960] [EC:1.3.1.83 1.3.1.111]
112702176  geranylgeranyl diphosphate reductase, chloroplastic [KO:K10960] [EC:1.3.1.83 1.3.1.111]
112722504  geranylgeranyl diphosphate reductase, chloroplastic [KO:K10960] [EC:1.3.1.83 1.3.1.111]
112762670  geranylgeranyl diphosphate reductase, chloroplastic isoform X1 [KO:K10960] [EC:1.3.1.83 1.3.1.111]
112789658  tricyclene synthase EBOS, chloroplastic [KO:K12742] [EC:4.2.3.27]
112712397  isoprene synthase, chloroplastic [KO:K12742] [EC:4.2.3.27]
112772760  isoprene synthase, chloroplastic [KO:K12742] [EC:4.2.3.27]
112772761  isoprene synthase, chloroplastic-like [KO:K12742] [EC:4.2.3.27]
112737563  tricyclene synthase EBOS, chloroplastic [KO:K12742] [EC:4.2.3.27]
112779715  isoprene synthase, chloroplastic [KO:K12742] [EC:4.2.3.27]
112707039  isoprene synthase, chloroplastic [KO:K12742] [EC:4.2.3.27]
112707040  isoprene synthase, chloroplastic [KO:K12742] [EC:4.2.3.27]
112771678  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [KO:K05955] [EC:2.5.1.58 2.5.1.59]
112706610  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha isoform X1 [KO:K05955] [EC:2.5.1.58 2.5.1.59]
112802464  protein farnesyltransferase subunit beta [KO:K05954] [EC:2.5.1.58]
112750798  protein farnesyltransferase subunit beta [KO:K05954] [EC:2.5.1.58]
112707122  protein farnesyltransferase subunit beta [KO:K05954] [EC:2.5.1.58]
112727138  CAAX prenyl protease 2 isoform X1 [KO:K08658] [EC:3.4.26.1]
112732810  CAAX prenyl protease 1 homolog isoform X1 [KO:K06013] [EC:3.4.24.84]
112726349  CAAX prenyl protease 1 homolog [KO:K06013] [EC:3.4.24.84]
112726350  CAAX prenyl protease 1 homolog isoform X1 [KO:K06013] [EC:3.4.24.84]
112750849  protein-S-isoprenylcysteine O-methyltransferase B isoform X1 [KO:K00587] [EC:2.1.1.100]
112802414  protein-S-isoprenylcysteine O-methyltransferase B isoform X1 [KO:K00587] [EC:2.1.1.100]
112716684  isoprenylcysteine alpha-carbonyl methylesterase ICME [KO:K15889] [EC:3.1.1.-]
112796108  isoprenylcysteine alpha-carbonyl methylesterase ICME [KO:K15889] [EC:3.1.1.-]
112719718  isoprenylcysteine alpha-carbonyl methylesterase ICME [KO:K15889] [EC:3.1.1.-]
112783318  isoprenylcysteine alpha-carbonyl methylesterase ICME [KO:K15889] [EC:3.1.1.-]
112771151  farnesylcysteine lyase [KO:K05906] [EC:1.8.3.5 1.8.3.6]
112707944  farnesylcysteine lyase [KO:K05906] [EC:1.8.3.5 1.8.3.6]
112705833  uncharacterized protein LOC112705833 isoform X1 [KO:K15891] [EC:1.1.1.354]
112766223  uncharacterized protein LOC112766223 isoform X1 [KO:K15891] [EC:1.1.1.354]
112792546  probable phytol kinase 3, chloroplastic [KO:K15892] [EC:2.7.1.216]
112719976  probable phytol kinase 3, chloroplastic [KO:K15892] [EC:2.7.1.216]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00118  D-Glyceraldehyde 3-phosphate
C00129  Isopentenyl diphosphate
C00235  Dimethylallyl diphosphate
C00332  Acetoacetyl-CoA
C00341  Geranyl diphosphate
C00353  Geranylgeranyl diphosphate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00448  trans,trans-Farnesyl diphosphate
C01107  (R)-5-Phosphomevalonate
C01126  (2E,6E)-Farnesol
C01143  (R)-5-Diphosphomevalonate
C01230  all-trans-Hexaprenyl diphosphate
C02321  cis-1,4-Polyisoprene
C03461  2-trans,6-trans-Farnesal
C04145  all-trans-Nonaprenyl diphosphate
C04146  all-trans-Octaprenyl diphosphate
C04216  all-trans-Heptaprenyl diphosphate
C04506  Protein C-terminal S-farnesyl-L-cysteine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04748  Protein C-terminal S-farnesyl-L-cysteine methyl ester
C05427  Phytyl diphosphate
C05859  ditrans,polycis-Polyprenyl diphosphate
C06081  Polyprenol
C11434  2-C-Methyl-D-erythritol 4-phosphate
C11435  4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11436  2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
C11437  1-Deoxy-D-xylulose 5-phosphate
C11453  2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
C11811  1-Hydroxy-2-methyl-2-butenyl 4-diphosphate
C16521  Isoprene
C16826  2-cis,6-trans-Farnesyl diphosphate
C17432  all-trans-Decaprenyl diphosphate
C18321  trans,octacis-Decaprenyl diphosphate
C19691  Farnesylcysteine
C19760  2-cis,6-cis-Farnesyl diphosphate
C19852  tritrans,heptacis-Undecaprenyl diphosphate
C19853  trans,polycis-Polyprenyl diphosphate
C20120  S-Farnesyl protein
C20121  trans,trans-Farnesyl phosphate
C20345  Isopentenyl phosphate
C20847  (R)-Mevalonate 3-phosphate
C20848  (R)-Mevalonate 3,5-bisphosphate
C22453  trans-Anhydromevalonate 5-phosphate
Reference
PMID:12777052
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
Reference
PMID:16262699
  Authors
Saiki R, Nagata A, Kainou T, Matsuda H, Kawamukai M
  Title
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
  Journal
FEBS J 272:5606-22 (2005)
DOI:10.1111/j.1742-4658.2005.04956.x
Reference
PMID:9858571
  Authors
Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A
  Title
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.
  Journal
Mol Cell Biol 19:471-83 (1999)
DOI:10.1128/MCB.19.1.471
Reference
PMID:24375100
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
Related
pathway
ahf00010  Glycolysis / Gluconeogenesis
ahf00100  Steroid biosynthesis
ahf00130  Ubiquinone and other terpenoid-quinone biosynthesis
ahf00270  Cysteine and methionine metabolism
ahf00510  N-Glycan biosynthesis
ahf00902  Monoterpenoid biosynthesis
ahf00904  Diterpenoid biosynthesis
ahf00906  Carotenoid biosynthesis
ahf00908  Zeatin biosynthesis
ahf00909  Sesquiterpenoid and triterpenoid biosynthesis
KO pathway
ko00900   
LinkDB

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