KEGG   PATHWAY: aip00270
Entry
aip00270                    Pathway                                
Name
Cysteine and methionine metabolism - Arachis ipaensis
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
aip00270  Cysteine and methionine metabolism
aip00270

Module
aip_M00021  Cysteine biosynthesis, serine => cysteine [PATH:aip00270]
aip_M00034  Methionine salvage pathway [PATH:aip00270]
aip_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:aip00270]
Other DBs
GO: 0006534 0006555
Organism
Arachis ipaensis [GN:aip]
Gene
107617967  serine acetyltransferase 3, mitochondrial [KO:K00640] [EC:2.3.1.30]
107642029  serine acetyltransferase 3, mitochondrial-like isoform X1 [KO:K00640] [EC:2.3.1.30]
107608772  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
107614737  serine acetyltransferase 3, mitochondrial-like [KO:K00640] [EC:2.3.1.30]
107619880  serine acetyltransferase 4-like [KO:K00640] [EC:2.3.1.30]
107642008  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
107645484  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
107642518  serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
107623038  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
107633900  serine acetyltransferase 3, mitochondrial-like [KO:K00640] [EC:2.3.1.30]
107631161  cysteine synthase, chloroplastic/chromoplastic [KO:K01738] [EC:2.5.1.47]
107643245  cysteine synthase [KO:K01738] [EC:2.5.1.47]
107610516  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
107643408  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
107609209  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
107618016  cysteine synthase [KO:K01738] [EC:2.5.1.47]
107618189  putative inactive cysteine synthase 2 isoform X2 [KO:K01738] [EC:2.5.1.47]
107605373  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
107635094  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
107621508  L-3-cyanoalanine synthase 2, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
107645543  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
107645201  selenocysteine methyltransferase isoform X1 [KO:K00547] [EC:2.1.1.10]
107610739  selenocysteine methyltransferase-like [KO:K00547] [EC:2.1.1.10]
107618670  LOW QUALITY PROTEIN: homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
107623306  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
107604827  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2 [KO:K00549] [EC:2.1.1.14]
107646031  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
107635276  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
107645976  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
107648443  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
107619953  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
107635512  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107637524  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
107616931  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
107628554  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107643762  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
107642026  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
107643373  spermidine synthase [KO:K00797] [EC:2.5.1.16]
107631462  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
107605938  spermine synthase [KO:K00797] [EC:2.5.1.16]
107619807  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
107612042  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
107645954  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
107605910  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1 [KO:K01244] [EC:3.2.2.16]
107623636  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
107609267  methylthioribose kinase 1-like [KO:K00899] [EC:2.7.1.100]
107617720  methylthioribose kinase isoform X1 [KO:K00899] [EC:2.7.1.100]
107617721  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
107613513  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
107613086  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
107626512  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107617398  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107617399  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107606079  uncharacterized protein LOC107606079 [KO:K23977] [EC:2.6.1.117]
107613484  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107630223  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107613564  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
107629831  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
107618199  uncharacterized protein LOC107618199 [KO:K00837] [EC:2.6.1.-]
107637498  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
107618704  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
107644434  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
107644685  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
107622392  DNA (cytosine-5)-methyltransferase CMT2 isoform X1 [KO:K00558] [EC:2.1.1.37]
107642522  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
107645905  uncharacterized protein LOC107645905 [KO:K17398] [EC:2.1.1.37]
107629428  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
107638233  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
107630758  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
107628111  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
107638081  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
107634514  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
107641657  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
107617450  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
107644474  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
107607955  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
107609126  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107644485  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
107638664  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107609932  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
107608930  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
107608931  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
107636528  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107606021  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
107613537  aspartokinase 2, chloroplastic-like isoform X3 [KO:K00928] [EC:2.7.2.4]
107604858  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
107629421  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107631792  uncharacterized protein LOC107631792 [KO:K00133] [EC:1.2.1.11]
107635351  cystathionine gamma-synthase 1, chloroplastic isoform X1 [KO:K01739] [EC:2.5.1.48]
107622851  cystathionine gamma-synthase 1, chloroplastic isoform X1 [KO:K01739] [EC:2.5.1.48]
107642674  branched-chain amino acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
107606337  branched-chain-amino-acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
107607080  putative branched-chain-amino-acid aminotransferase 7 [KO:K00826] [EC:2.6.1.42]
107626259  branched-chain-amino-acid aminotransferase 6 [KO:K00826] [EC:2.6.1.42]
107627996  branched-chain-amino-acid aminotransferase 6-like [KO:K00826] [EC:2.6.1.42]
107631121  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107639616  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107625848  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107644266  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107630795  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
107646238  LOW QUALITY PROTEIN: glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107645872  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107622437  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
107630035  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
107605400  aspartate aminotransferase P2, mitochondrial [KO:K00811] [EC:2.6.1.1]
107613240  thiosulfate/3-mercaptopyruvate sulfurtransferase 2 isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
107640213  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
107629994  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
107625328  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial [KO:K05396] [EC:4.4.1.15]
107623803  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
107645985  LOW QUALITY PROTEIN: probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
107618418  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
107619001  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
107624813  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
107617411  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
107617412  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
107630073  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
107642662  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
107626268  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
107633125  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
107604759  probable S-sulfocysteine synthase, chloroplastic isoform X1 [KO:K22846] [EC:2.5.1.144]
107614628  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107638367  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107617237  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107642515  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
aip00010  Glycolysis / Gluconeogenesis
aip00250  Alanine, aspartate and glutamate metabolism
aip00260  Glycine, serine and threonine metabolism
aip00290  Valine, leucine and isoleucine biosynthesis
aip00430  Taurine and hypotaurine metabolism
aip00480  Glutathione metabolism
aip00620  Pyruvate metabolism
aip00640  Propanoate metabolism
aip00770  Pantothenate and CoA biosynthesis
aip00900  Terpenoid backbone biosynthesis
aip00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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