KEGG   PATHWAY: ajm00260
Entry
ajm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ajm00260  Glycine, serine and threonine metabolism
ajm00260

Module
ajm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ajm00260]
ajm_M00047  Creatine pathway [PATH:ajm00260]
ajm_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ajm00260]
ajm_M00555  Betaine biosynthesis, choline => betaine [PATH:ajm00260]
ajm_M00621  Glycine cleavage system [PATH:ajm00260]
ajm_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ajm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119035676  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
119059459  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
119062240  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
119061034  AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
119048879  glycerate dehydrogenase HPR, peroxisomal [KO:K15893] [EC:1.1.1.29]
119048765  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
119041431  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
119044526  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
119052850  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
119064246  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
119060933  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
119054810  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
119041746  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
119035900  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
119055047  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
119060543  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
119049438  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
119036597  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
119055496  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
119042157  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
119042158  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
119051774  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
119051797  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
119040238  glycine dehydrogenase (decarboxylating) A, mitochondrial-like [KO:K00281] [EC:1.4.4.2]
119057834  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
119043857  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
119036697  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
119054882  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
119049224  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
119057430  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
119037022  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119064613  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
119054327  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
119044189  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
119041389  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
119041281  betaine aldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
119044019  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
119035984  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
119048139  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
119062029  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
119036072  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
119041338  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
119056163  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
119048800  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
119045308  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
119052698  LOW QUALITY PROTEIN: L-serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119057463  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119057465  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119040672  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
119062423  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ajm00010  Glycolysis / Gluconeogenesis
ajm00020  Citrate cycle (TCA cycle)
ajm00230  Purine metabolism
ajm00250  Alanine, aspartate and glutamate metabolism
ajm00270  Cysteine and methionine metabolism
ajm00290  Valine, leucine and isoleucine biosynthesis
ajm00300  Lysine biosynthesis
ajm00330  Arginine and proline metabolism
ajm00470  D-Amino acid metabolism
ajm00564  Glycerophospholipid metabolism
ajm00600  Sphingolipid metabolism
ajm00620  Pyruvate metabolism
ajm00630  Glyoxylate and dicarboxylate metabolism
ajm00640  Propanoate metabolism
ajm00860  Porphyrin metabolism
ajm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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