KEGG   PATHWAY: ajm04727
Entry
ajm04727                    Pathway                                
Name
GABAergic synapse - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
ajm04727  GABAergic synapse
ajm04727

Other DBs
GO: 0051932
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119061700  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
119049877  SLC38A2; sodium-coupled neutral amino acid transporter 2 [KO:K14207]
119040311  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
119062094  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
119044936  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
119050159  GAD2; glutamate decarboxylase 2 isoform X1 [KO:K01580] [EC:4.1.1.15]
119050701  glutamate decarboxylase [KO:K01580] [EC:4.1.1.15]
119063290  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
119048654  vacuolar amino acid transporter 1-like [KO:K15015]
119049875  vesicular inhibitory amino acid transporter-like [KO:K15015]
119041358  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
119039863  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
119040358  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
119046076  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
119046611  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175]
119046615  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
119054041  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
119039862  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
119046610  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
119063567  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
119039300  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
119039859  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
119054042  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
119050578  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
119040365  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
119036225  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
119062886  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
119049690  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119063248  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119036326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119043241  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
119036009  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119037569  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
119037145  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
119048917  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119065688  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
119062605  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
119065485  TRAK2; LOW QUALITY PROTEIN: trafficking kinesin-binding protein 2 [KO:K15374]
119065499  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
119034793  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
119063182  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
119038682  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
119038689  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
119049676  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
119036142  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119051688  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119041393  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119059521  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119060725  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
119045908  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
119065154  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
119036589  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
119040343  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
119054511  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
119046437  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
119050543  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
119041561  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119060292  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
119042999  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
119047600  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
119056979  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
119045494  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
119044222  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
119062889  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119063727  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
119056651  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
119054673  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119047352  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
119049326  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119049544  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119049645  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119058263  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
119047351  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
119052611  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
119057313  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
119049317  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119050413  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
119037286  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119039523  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
119042160  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
119046468  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
119064806  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119056281  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
119035740  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
119044801  SLC6A1; sodium- and chloride-dependent GABA transporter 1 isoform X1 [KO:K05034]
119040827  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
119044783  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
119041428  sodium- and chloride-dependent GABA transporter 3-like [KO:K05044]
119040817  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
119039442  glutamine synthetase 2 cytoplasmic-like [KO:K01915] [EC:6.3.1.2]
119049602  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
119049888  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
119036584  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
ajm00020  Citrate cycle (TCA cycle)
ajm00250  Alanine, aspartate and glutamate metabolism
ajm04144  Endocytosis
ajm04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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