KEGG   PATHWAY: aju00260
Entry
aju00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Acinonyx jubatus (cheetah)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aju00260  Glycine, serine and threonine metabolism
aju00260

Module
aju_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aju00260]
aju_M00047  Creatine pathway [PATH:aju00260]
aju_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:aju00260]
aju_M00555  Betaine biosynthesis, choline => betaine [PATH:aju00260]
aju_M00621  Glycine cleavage system [PATH:aju00260]
aju_M00974  Betaine metabolism, animals, betaine => glycine [PATH:aju00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106981894  uncharacterized protein LOC106981894 [KO:K01620] [EC:4.1.2.48]
106981427  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
106975854  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
106984612  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
106981283  glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
106987034  glycerate kinase [KO:K11529] [EC:2.7.1.165]
106968208  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
106966927  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
106975708  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
106978498  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
106975319  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
106972853  phosphoserine phosphatase isoform X2 [KO:K01079] [EC:3.1.3.3]
106981020  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
106975805  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
106986505  5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
106987031  5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
106972520  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
106972743  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
106972620  retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
113598066  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
106989832  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
106985302  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
106979240  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
106980658  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
106984005  glycine cleavage system H protein, mitochondrial [KO:K02437]
106988727  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
106978240  D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
106980604  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
106986286  glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
106983718  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
106987035  choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
106970741  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106974816  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
106974795  dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
106983269  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
106988257  sarcosine dehydrogenase, mitochondrial isoform X2 [KO:K00314] [EC:1.5.8.3]
106973967  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
106985645  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
106982700  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
106982073  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
106982100  serine dehydratase-like isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
106983203  serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aju00010  Glycolysis / Gluconeogenesis
aju00020  Citrate cycle (TCA cycle)
aju00230  Purine metabolism
aju00250  Alanine, aspartate and glutamate metabolism
aju00270  Cysteine and methionine metabolism
aju00290  Valine, leucine and isoleucine biosynthesis
aju00330  Arginine and proline metabolism
aju00470  D-Amino acid metabolism
aju00564  Glycerophospholipid metabolism
aju00600  Sphingolipid metabolism
aju00620  Pyruvate metabolism
aju00630  Glyoxylate and dicarboxylate metabolism
aju00640  Propanoate metabolism
aju00860  Porphyrin metabolism
aju00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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