KEGG   PATHWAY: amj04914
Entry
amj04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Alligator mississippiensis (American alligator)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
amj04914  Progesterone-mediated oocyte maturation
amj04914

Other DBs
GO: 0001556
Organism
Alligator mississippiensis (American alligator) [GN:amj]
Gene
102575476  PGR; progesterone receptor [KO:K08556]
106737141  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102567863  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102570922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102564312  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106737094  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102571877  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102566087  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102570366  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102570628  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102571419  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102571177  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
106736779  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102565670  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
106737098  GNAI2; G protein subunit alpha i2 [KO:K04630]
102571369  GNAI1; G protein subunit alpha i1 [KO:K04630]
102567683  GNAI3; G protein subunit alpha i3 [KO:K04630]
102573818  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102562034  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102566746  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102558956  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102562224  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102573402  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102566330  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102562540  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102574362  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102572143  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106737076  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102563949  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
102563713  CPEB1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602]
102557656  CPEB2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602]
102573824  CPEB3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602]
106737061  CPEB4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602]
102571813  SPDYA; speedy/RINGO cell cycle regulator family member A [KO:K08694]
102561081  SPDYC; speedy/RINGO cell cycle regulator family member C [KO:K08694]
102570724  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102568663  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102568074  CCNA2; cyclin A2 [KO:K06627]
102570094  CCNA1; cyclin A1 [KO:K06627]
102572058  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
102566230  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102558280  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102563228  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106737342  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102561718  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109282845  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
102563194  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102574678  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102561736  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102571036  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102573832  PKMYT1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1]
102573326  CCNB1; cyclin B1 [KO:K05868]
102564267  CCNB2; cyclin B2 [KO:K21770]
102570330  CCNB3; cyclin B3 [KO:K21771]
102560258  STK10; serine/threonine kinase 10 [KO:K08837] [EC:2.7.11.1]
102561861  PLK1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
102569214  CDC25A; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
102576728  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102572255  CDC25C; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
102565762  INS; insulin [KO:K04526]
102559209  IGF1; insulin like growth factor 1 [KO:K05459]
106736787  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102574794  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102558879  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102564996  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102562481  PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
102574430  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102575936  GTPase HRas [KO:K07827]
106737102  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102576986  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102562842  BUB1; BUB1 mitotic checkpoint serine/threonine kinase [KO:K02178] [EC:2.7.11.1]
102570055  MAD1L1; MAD1 mitotic arrest deficient like 1 [KO:K06679]
102563766  MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) [KO:K02537]
102558307  MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
102576993  FZR1; fizzy/cell division cycle 20 related 1 [KO:K03364]
102560517  ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
102570336  ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
102570656  CDC27; cell division cycle 27 [KO:K03350]
102571851  ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
102564919  ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
102569013  CDC16; cell division cycle 16 [KO:K03353]
102563615  ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
102571800  CDC23; cell division cycle 23 [KO:K03355]
102558338  ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
102569950  ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
102562333  CDC26; cell division cycle 26 [KO:K03359]
102568227  ANAPC13; anaphase promoting complex subunit 13 [KO:K12456]
106737697  ANAPC15; anaphase promoting complex subunit 15 [KO:K25228]
102565975  ANAPC16; anaphase promoting complex subunit 16 [KO:K25229]
102561565  KIF22; kinesin family member 22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
amj04010  MAPK signaling pathway
amj04110  Cell cycle
KO pathway
ko04914   
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