KEGG   PATHWAY: asao00260
Entry
asao00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Anolis sagrei ordinatus (Brown anole)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
asao00260  Glycine, serine and threonine metabolism
asao00260

Module
asao_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:asao00260]
asao_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:asao00260]
asao_M00555  Betaine biosynthesis, choline => betaine [PATH:asao00260]
asao_M00621  Glycine cleavage system [PATH:asao00260]
asao_M00974  Betaine metabolism, animals, betaine => glycine [PATH:asao00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132768461  uncharacterized protein LOC132768461 isoform X1 [KO:K01620] [EC:4.1.2.48]
132781562  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
132767731  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
132770781  AGXT; alanine--glyoxylate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
132768119  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
132769169  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
132770865  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
132782444  PGAM2; phosphoglycerate mutase 2 isoform X1 [KO:K01834] [EC:5.4.2.11]
132775754  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
132774312  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
132767333  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
132763441  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
132775924  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
132761619  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
132767896  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
132769176  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
132771790  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
132771791  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
132778380  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
132778381  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
132779633  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
132770573  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
132767405  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
132769089  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
132776579  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
132782957  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
132781710  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
132766920  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
132781077  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
132769270  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
132767248  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
132767046  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
132767047  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
132763300  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132763715  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
132761523  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
132771809  cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]
132770008  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
132774037  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
132771279  LOW QUALITY PROTEIN: L-threonine ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]
132781303  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
132781304  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
132779045  D-serine dehydratase-like [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
asao00010  Glycolysis / Gluconeogenesis
asao00020  Citrate cycle (TCA cycle)
asao00230  Purine metabolism
asao00250  Alanine, aspartate and glutamate metabolism
asao00270  Cysteine and methionine metabolism
asao00290  Valine, leucine and isoleucine biosynthesis
asao00330  Arginine and proline metabolism
asao00470  D-Amino acid metabolism
asao00564  Glycerophospholipid metabolism
asao00600  Sphingolipid metabolism
asao00620  Pyruvate metabolism
asao00630  Glyoxylate and dicarboxylate metabolism
asao00640  Propanoate metabolism
asao00860  Porphyrin metabolism
asao00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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