KEGG   PATHWAY: ats03440
Entry
ats03440                    Pathway                                
Name
Homologous recombination - Aegilops tauschii (wheat D)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ats03440  Homologous recombination
ats03440

Other DBs
GO: 0000724
Organism
Aegilops tauschii (wheat D) [GN:ats]
Gene
109740129  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
109781983  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
109781056  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
109751561  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
109781014  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
109732217  ATP-dependent DNA helicase homolog RECG, chloroplastic [KO:K03655] [EC:5.6.2.4]
109733532  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
109734400  double-strand break repair protein MRE11-like [KO:K10865]
109748112  double-strand break repair protein MRE11 [KO:K10865]
109772932  nijmegen breakage syndrome 1 protein [KO:K10867]
109742816  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
109748902  BRCA1-associated RING domain protein 1-like [KO:K10683]
109763934  BRCA1-associated RING domain protein 1-like [KO:K10683]
109779560  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
109765467  BRCA1-associated RING domain protein 1-like [KO:K10683]
109765941  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
109752033  DNA topoisomerase 2-binding protein 1-A isoform X1 [KO:K10728]
109761873  BRCT domain-containing protein At4g02110-like [KO:K10728]
109760520  BRCT domain-containing protein At4g02110-like [KO:K10728]
109785220  BRCT domain-containing protein At4g02110-like [KO:K10728]
109781087  uncharacterized protein LOC109781087 [KO:K10728]
109761757  uncharacterized protein LOC109761757 [KO:K20776]
109751650  BRCA1-A complex subunit BRE isoform X1 [KO:K12173]
109786764  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
109768542  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B isoform X1 [KO:K08775]
109756946  protein DELETION OF SUV3 SUPPRESSOR 1(I) [KO:K10881]
109739310  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
109733072  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
109741403  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
109783530  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
109781277  replication protein A 32 kDa subunit B-like [KO:K10739]
109767139  replication protein A 32 kDa subunit A-like [KO:K10739]
109732657  replication protein A 32 kDa subunit B-like [KO:K10739]
109734782  replication protein A 32 kDa subunit C-like [KO:K10739]
109739316  replication protein A 14 kDa subunit-like [KO:K10740]
109757096  replication protein A 14 kDa subunit-like [KO:K10740]
109738233  DNA repair protein RAD51 homolog B [KO:K04482]
109755681  DNA repair protein RAD51 homolog 2 [KO:K10869]
109787271  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
109760691  DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
109752110  DNA repair protein XRCC2 homolog isoform X1 [KO:K10879]
109775668  DNA repair protein XRCC3 homolog [KO:K10880]
109751478  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
109784835  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
109751064  DNA repair and recombination protein RAD54 [KO:K10875] [EC:5.6.2.-]
109764175  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
109769933  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
109737439  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
109735117  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
109741484  DNA polymerase delta small subunit [KO:K02328]
109737038  nucleolin 2 [KO:K03504]
109736864  uncharacterized protein LOC109736864 [KO:K03505]
109773730  DNA polymerase delta subunit 4-like [KO:K03505]
109780536  DNA polymerase delta subunit 4 [KO:K03505]
109751137  DNA polymerase delta subunit 4-like [KO:K03505]
109741081  uncharacterized protein LOC109741081 [KO:K03505]
109742312  DNA polymerase delta subunit 4-like [KO:K03505]
109768250  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:5.6.2.4]
109759466  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
109751468  DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
109764835  DNA topoisomerase 3-beta [KO:K03165] [EC:5.6.2.1]
109776070  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
109739429  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
109786307  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
109735648  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
109780207  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
109786011  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
109786012  crossover junction endonuclease EME1-like isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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