KEGG PATHWAY: bcai00260

KEGG

PATHWAY: bcai00260

Entry

bcai00260                   Pathway

Name

Glycine, serine and threonine metabolism - Paraburkholderia caribensis

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

Glycine, serine and threonine metabolism

Module

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bcai00260]

Serine biosynthesis, glycerate-3P => serine [PATH:bcai00260]

Betaine biosynthesis, choline => betaine [PATH:bcai00260]

Glycine cleavage system [PATH:bcai00260]

Ectoine degradation, ectoine => aspartate [PATH:bcai00260]

Betaine degradation, bacteria, betaine => pyruvate [PATH:bcai00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Paraburkholderia caribensis [GN:bcai]

Gene

aspartate kinase [KO:K00928] [EC:2.7.2.4]

aspartate kinase [KO:K00928] [EC:2.7.2.4]

Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

homoserine kinase [KO:K02204] [EC:2.7.1.39]

Threonine synthase [KO:K01733] [EC:4.2.3.1]

L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

Serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

Hydroxypyruvate reductase [KO:K00018] [EC:1.1.1.29]

Lactate dehydrogenase [KO:K00018] [EC:1.1.1.29]

Hydroxypyruvate reductase [KO:K00018] [EC:1.1.1.29]

D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]

D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]

2-ketogluconate 6-phosphate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

D-3-phosphoglycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

Glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

Glycerate kinase [KO:K00865] [EC:2.7.1.165]

Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

phosphoserine aminotransferase apoenzyme [KO:K00831] [EC:2.6.1.52]

Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

3-hydroxypropionate dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]

2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]

L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]

Glycine dehydrogenase, glycine cleavage system P protein [KO:K00281] [EC:1.4.4.2]

aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

Sarcosine oxidase alpha subunit [KO:K00605] [EC:2.1.2.10]

Aminomethyltransferase, glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]

Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]

Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

Glycine cleavage system H protein [KO:K02437]

Creatinase [KO:K08688] [EC:3.5.3.3]

CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenase, large terminal subunit [KO:K00479] [EC:1.14.13.251]

Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenase, large terminal subunit [KO:K00479] [EC:1.14.13.251]

Flavodoxin reductases ferredoxin-NADPH reductases family 1 [KO:K21832] [EC:1.14.13.251]

Flavodoxin reductase ferredoxin-NADPH reductase family 1 [KO:K21832] [EC:1.14.13.251]

DgcA Dimethylglycine demethylase subunit A [KO:K21833] [EC:1.5.7.3]

Iron-sulfur cluster-binding protein [KO:K21834]

electron transfer flavoprotein alpha subunit apoprotein [KO:K25960]

electron transfer flavoprotein beta subunit [KO:K25961]

Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]

Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]

N-methylglutamate dehydrogenase subunit D [KO:K00305] [EC:1.5.3.24 1.5.3.1]

Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]

Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

serine dehydratase [KO:K01752] [EC:4.3.1.17]

L-serine dehydratase [KO:K01752] [EC:4.3.1.17]

Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]

putative amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]

Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]

Threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]

L-serine dehydratase, (PLP)-dependent/Threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

low-specificity D-threonine aldolase [KO:K01753] [EC:4.3.1.18]

Aspartate racemase [KO:K25316] [EC:5.1.1.10]

tryptophan synthase, alpha chain [KO:K01695] [EC:4.2.1.20]

Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]

Aminopeptidase YpdF [KO:K15783] [EC:3.5.4.44]

succinate dehydrogenase subunit [KO:K15784] [EC:3.5.1.125]

Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase [KO:K15785] [EC:2.6.1.76]

Succinate-semialdehyde dehydrogenase [NADP+] [KO:K15786] [EC:1.2.1.-]

Compound

CO2

Ammonia

Pyruvate

Glycine

Glyoxylate

L-Aspartate

L-Serine

L-Tryptophan

L-Cysteine

Tetrahydrofolate

2-Oxobutanoate

Choline

5,10-Methylenetetrahydrofolate

Hydroxypyruvate

L-Threonine

3-Phospho-D-glycerate

Sarcosine

D-Glycerate

L-Homoserine

Creatine

5-Aminolevulinate

L-Aspartate 4-semialdehyde

Methylglyoxal

Betaine aldehyde

Guanidinoacetate

2-Phospho-D-glycerate

Betaine

D-Serine

1,3-Diaminopropane

O-Phospho-L-serine

N,N-Dimethylglycine

O-Phospho-L-homoserine

[Protein]-S8-aminomethyldihydrolipoyllysine

Aminoacetone

Lipoylprotein

L-Cystathionine

Phosphatidylserine

Dihydrolipoylprotein

4-Phospho-L-aspartate

(R)-1-Aminopropan-2-ol

3-Phosphonooxypyruvate

L-2,4-Diaminobutanoate

L-2-Amino-3-oxobutanoic acid

L-Allothreonine

Ectoine

N(gamma)-Acetyldiaminobutyrate

5-Hydroxyectoine

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

Authors

Rees WD, Hay SM

Title

The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.

Journal

Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999

Reference

Authors

Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD

Title

Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.

Journal

Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X

Reference

Authors

Chen X, Jhee KH, Kruger WD

Title

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.

Journal

J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200

Related
pathway

Glycolysis / Gluconeogenesis

Citrate cycle (TCA cycle)

Purine metabolism

Alanine, aspartate and glutamate metabolism

Cysteine and methionine metabolism

Valine, leucine and isoleucine biosynthesis

Lysine biosynthesis

Arginine and proline metabolism

Cyanoamino acid metabolism

D-Amino acid metabolism

Glycerophospholipid metabolism

Sphingolipid metabolism

Pyruvate metabolism

Glyoxylate and dicarboxylate metabolism

Propanoate metabolism

Methane metabolism

Porphyrin metabolism

Sulfur metabolism

KO pathway

LinkDB

DBGET integrated database retrieval system