KEGG   PATHWAY: biu04142
Entry
biu04142                    Pathway                                
Name
Lysosome - Bos indicus (zebu cattle)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
biu04142  Lysosome
biu04142

Other DBs
GO: 0005764
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109557679  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109554146  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109571337  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109573940  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
109553028  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
109572238  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
109568708  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
109568590  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
109555332  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
109562834  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
109578503  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
109556392  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
109560986  DMXL1; dmX-like protein 1 [KO:K24155]
109564368  DMXL2; dmX-like protein 2 [KO:K24155]
109577830  WDR7; WD repeat-containing protein 7 [KO:K24738]
109563754  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
109567503  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
109562776  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
109554360  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
109554428  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
109554136  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
109575203  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
109575305  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
109575407  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
109555331  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
109563231  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
109571466  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
109555340  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
109554432  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
109567290  CTSZ; cathepsin Z isoform X1 [KO:K08568] [EC:3.4.18.1]
109571911  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
109569865  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
109555255  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
109576213  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
109574062  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
109553697  GBA; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
109560709  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
109559874  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
109573307  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
109579018  alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]
109565404  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
109578159  GUSB; LOW QUALITY PROTEIN: beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
109573881  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
109564003  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
109574859  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
109575074  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
109564744  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
109560295  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
109561547  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
109577336  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
109557586  HYAL4; LOW QUALITY PROTEIN: hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
109557587  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
109557935  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
109558119  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
109576069  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
109576071  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
109576073  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
109564662  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
109573364  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
109572729  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
109559271  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
109554785  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
109574273  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
109579141  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
109572091  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
109556135  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
109561533  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
109569542  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
109561630  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
109569729  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
109553501  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
109553504  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
109553684  PSAP; prosaposin isoform X1 [KO:K12382]
109560756  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
109562220  GM2A; ganglioside GM2 activator [KO:K12383]
109556456  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
109576851  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
109555141  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
109567028  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
109557632  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
109573604  CD68; macrosialin [KO:K06501]
109559395  CD63; CD63 antigen [KO:K06497]
109560597  SCARB2; lysosome membrane protein 2 [KO:K12384]
109577835  NPC1; Niemann-Pick C1 protein [KO:K12385]
109565348  NPC2; epididymal secretory protein E1 isoform X1 [KO:K13443]
109573897  CTNS; cystinosin [KO:K12386]
109563707  SLC17A5; sialin isoform X1 [KO:K12301]
109570553  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
109559099  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
109559101  LOW QUALITY PROTEIN: natural resistance-associated macrophage protein 2-like [KO:K21398]
109558353  natural resistance-associated macrophage protein 2-like [KO:K21398]
109568492  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
109572680  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
109566356  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
109571523  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
109563839  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
109563130  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
109555979  SORT1; sortilin isoform X1 [KO:K12388]
109578637  CLN3; battenin [KO:K12389]
109567068  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
109571176  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
109553469  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
109576370  SUMF1; sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
109559441  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
109578483  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
109578760  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
109564096  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
109559693  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
109563034  CLTA; clathrin light chain A isoform X1 [KO:K04644]
109561880  CLTB; clathrin light chain B [KO:K04645]
109573167  CLTC; clathrin heavy chain 1 [KO:K04646]
109564791  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
109572430  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
109571219  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
109561596  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
109561465  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
109555179  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
109578775  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
109575840  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
109561803  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
109575769  AP3B2; LOW QUALITY PROTEIN: AP-3 complex subunit beta-2 [KO:K12397]
109564658  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
109553736  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
109553541  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
109575467  AP-3 complex subunit sigma-2 [KO:K12399]
109564626  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
109565553  LOW QUALITY PROTEIN: AP-3 complex subunit sigma-1-like [KO:K12399]
109565127  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
109555903  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
109578369  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
109575611  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
109578132  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
109559791  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
109561640  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
109578087  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
109578593  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
biu00511  Other glycan degradation
biu00531  Glycosaminoglycan degradation
biu04130  SNARE interactions in vesicular transport
biu04140  Autophagy - animal
biu04144  Endocytosis
KO pathway
ko04142   
LinkDB

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