KEGG   PATHWAY: bta03420
Entry
bta03420                    Pathway                                
Name
Nucleotide excision repair - Bos taurus (cow)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
bta03420  Nucleotide excision repair
bta03420

Other DBs
GO: 0006289
Organism
Bos taurus (cow) [GN:bta]
Gene
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
780968  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
539668  CUL4B; cullin-4B isoform X1 [KO:K10609]
617935  CUL4A; cullin-4A [KO:K10609]
511951  DDB1; DNA damage-binding protein 1 [KO:K10610]
519357  DDB2; DNA damage-binding protein 2 [KO:K10140]
524274  XPC; DNA repair protein complementing XP-C cells [KO:K10838]
530189  RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]
540564  RAD23A; UV excision repair protein RAD23 homolog A [KO:K10839]
508601  CETN2; centrin-2 [KO:K10840]
518857  ERCC8; DNA excision repair protein ERCC-8 [KO:K10570]
522908  ERCC6; DNA excision repair protein ERCC-6 [KO:K10841]
510550  UVSSA; UV-stimulated scaffold protein A isoform X3 [KO:K23720]
282312  POLR2A; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
538184  POLR2B; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
504452  POLR2C; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
617422  POLR2D; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]
512971  POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
534232  POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
526320  POLR2G; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
505599  POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
614472  POLR2I; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
617375  POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
614776  POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
540428  POLR2J; DNA-directed RNA polymerase II subunit RPB11 [KO:K03008]
100125877  POLR2M; DNA-directed RNA polymerase II subunit GRINL1A [KO:K21987]
515462  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
534176  MNAT1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
615512  CCNH; cyclin-H [KO:K06634]
507984  ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
100125238  ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:5.6.2.3]
518046  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
513510  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
511829  GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]
511896  GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]
100137723  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
509602  ERCC5; DNA excision repair protein ERCC-5 [KO:K10846]
537958  XPA; DNA repair protein complementing XP-A cells [KO:K10847]
504844  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
507912  RPA2; replication protein A 32 kDa subunit [KO:K10739]
512754  RPA3; replication protein A 14 kDa subunit [KO:K10740]
104971312  RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741]
516371  ERCC4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
615637  ERCC1; DNA excision repair protein ERCC-1 [KO:K10849]
281990  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
281991  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
537616  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
617899  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
785457  POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
518653  POLE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
510678  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
613730  POLE4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:2.7.7.7]
515499  PCNA; proliferating cell nuclear antigen [KO:K04802]
514842  RFC1; replication factor C subunit 1 isoform X1 [KO:K10754]
504637  RFC4; replication factor C subunit 4 [KO:K10755]
508652  RFC2; replication factor C subunit 2 [KO:K10755]
508389  RFC5; replication factor C subunit 5 [KO:K10756]
515602  RFC3; replication factor C subunit 3 [KO:K10756]
100124507  LIG1; DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
bta03020  RNA polymerase
bta04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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