KEGG   PATHWAY: bta04120
Entry
bta04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Bos taurus (cow)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bta04120  Ubiquitin mediated proteolysis
bta04120

Other DBs
GO: 0016567
Organism
Bos taurus (cow) [GN:bta]
Gene
100138178  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
100138545  PML; protein PML [KO:K10054] [EC:2.3.2.-]
100139990  [KO:K10613]
100140342  [KO:K04506] [EC:2.3.2.27]
100299705  [KO:K05632] [EC:2.3.2.26]
100336539  [KO:K04506] [EC:2.3.2.27]
100336564  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
101905053  [KO:K16060]
101905242  [KO:K25228]
101906182  [KO:K04506] [EC:2.3.2.27]
101907097  [KO:K04506] [EC:2.3.2.27]
112443016  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
112445131  [KO:K04506] [EC:2.3.2.27]
112445697  [KO:K07868]
112446327  [KO:K03347]
112446383  [KO:K10577]
132343864  [KO:K03873]
132344841  [KO:K02977]
281225  UBE2K; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
281370  UBB; polyubiquitin-B [KO:K08770]
281647  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
282081  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
282107  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
282869  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
286839  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
326583  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
353120  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
407228  CUL1; cullin-1 [KO:K03347]
444874  UBC; polyubiquitin-C [KO:K08770]
497204  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
504558  CUL7; cullin-7 [KO:K10613]
504565  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
505133  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
505356  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
505512  SAE1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
506103  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
506962  UBE2C; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
507005  UBA2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
507781  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X2 [KO:K10591] [EC:2.3.2.26]
508358  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
508431  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
508513  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
509231  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
509471  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
510003  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
510331  CUL5; cullin-5 isoform X2 [KO:K10612]
510924  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
511467  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
511631  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 [KO:K10582] [EC:2.3.2.23]
511801  UBE2D4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
511826  HUWE1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
511951  DDB1; DNA damage-binding protein 1 [KO:K10610]
512207  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
512457  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
512589  FBXO2; F-box only protein 2 [KO:K10099]
512647  UBA3; NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
512651  CDC23; cell division cycle protein 23 homolog [KO:K03355]
512750  UBE3B; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
513789  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
513868  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
513902  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X3 [KO:K04678] [EC:2.3.2.26]
514386  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
514387  TRIP12; E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
514445  UBOX5; RING finger protein 37 [KO:K10600] [EC:2.3.2.27]
514508  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
514572  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
515376  CDC20; cell division cycle protein 20 homolog [KO:K03363]
515573  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
515582  UBR5; E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
515595  RNF7; RING-box protein 2 [KO:K10611]
517544  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
518795  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
518834  UBA6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
518857  ERCC8; DNA excision repair protein ERCC-8 [KO:K10570]
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
519018  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
519357  DDB2; DNA damage-binding protein 2 [KO:K10140]
519896  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
520833  UBE4B; ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
521975  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
523962  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
525906  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
527418  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
528138  KLHL13; kelch-like protein 13 [KO:K10447]
529930  [KO:K10604] [EC:2.3.2.27]
530333  FZR1; fizzy-related protein homolog [KO:K03364]
530858  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
532791  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
533136  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
533336  HERC4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
533403  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
534072  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
534211  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
534325  CUL3; cullin-3 [KO:K03869]
534349  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
534604  MID1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
534655  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
534722  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
534852  FBXO4; F-box only protein 4 [KO:K10291]
535072  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
535219  CUL2; cullin-2 [KO:K03870]
535287  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
535312  PIAS3; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
535440  HERC2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
535565  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
537885  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
538029  HERC1; probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
538814  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
539313  UBE2H; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
539314  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
539668  CUL4B; cullin-4B isoform X1 [KO:K10609]
539754  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
540089  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
540378  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
540513  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
540537  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
540642  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
540660  CDC27; cell division cycle protein 27 homolog [KO:K03350]
540733  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
540826  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
540859  ELOC; elongin-C [KO:K03872]
540932  FBXW7; F-box/WD repeat-containing protein 7 [KO:K10260]
540957  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
541003  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
541005  DET1; DET1 homolog [KO:K10571]
541130  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
613343  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
613423  UBE2W; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
613676  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
613985  [KO:K07868]
614342  CDC16; cell division cycle protein 16 homolog [KO:K03353]
614347  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
614471  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
614512  FANCL; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
615199  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
615427  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
615599  UBE2E1; ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
615866  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
616130  MGRN1; E3 ubiquitin-protein ligase MGRN1 [KO:K10604] [EC:2.3.2.27]
616156  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
616275  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
617078  TRIM37; E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
617083  UBE2F; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
617277  ELOB; elongin-B [KO:K03873]
617703  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
617935  CUL4A; cullin-4A [KO:K10609]
767834  KLHL9; kelch-like protein 9 [KO:K10447]
767894  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
777693  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
780968  [KO:K03868] [EC:2.3.2.32]
782032  [KO:K03175] [EC:2.3.2.27]
783986  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
784326  UBE2E2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
784567  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
784775  AIRE; autoimmune regulator isoform X2 [KO:K10603]
784843  [KO:K02927]
784986  UBE2U; ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
785617  [KO:K03875]
787118  FBXW8; F-box/WD repeat-containing protein 8 [KO:K10264]
789422  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
bta03050  Proteasome
KO pathway
ko04120   

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