KEGG   PATHWAY: caba00260
Entry
caba00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Caballeronia sp. SBC2
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
caba00260  Glycine, serine and threonine metabolism
caba00260

Module
caba_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:caba00260]
caba_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:caba00260]
caba_M00555  Betaine biosynthesis, choline => betaine [PATH:caba00260]
caba_M00621  Glycine cleavage system [PATH:caba00260]
caba_M00919  Ectoine degradation, ectoine => aspartate [PATH:caba00260]
caba_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:caba00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Caballeronia sp. SBC2 [GN:caba]
Gene
SBC2_13850  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
SBC2_56280  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SBC2_16520  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SBC2_56770  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
SBC2_16530  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
SBC2_25110  ltaE_1; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SBC2_45830  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SBC2_64030  ltaE_2; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SBC2_29960  glyA_1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SBC2_54600  glyA_2; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SBC2_55220  glyA2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
SBC2_42160  sgaA_1; Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SBC2_69730  sgaA_2; Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SBC2_49780  ghrA_2; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SBC2_49940  ghrA_3; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SBC2_01690  ghrA_1; Glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SBC2_26130  ghrB_3; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SBC2_62050  ghrB_4; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SBC2_20210  ghrB_2; Glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SBC2_16840  Glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
SBC2_02760  gpmA_1; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SBC2_04200  pspB; Putative phosphoserine phosphatase 2 [KO:K15634] [EC:5.4.2.11]
SBC2_00380  ghrB_1; Glyoxylate/hydroxypyruvate reductase B [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SBC2_70990  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SBC2_26890  serC_1; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SBC2_29460  serC_2; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SBC2_20630  haloacid dehalogenase-like hydrolase [KO:K01079] [EC:3.1.3.3]
SBC2_29970  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SBC2_63520  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SBC2_63530  tdh_4; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SBC2_53170  mao; 4-methylaminobutanoate oxidase (methylamine-forming) [KO:K00274] [EC:1.4.3.4]
SBC2_35370  gcvP; Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SBC2_35350  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SBC2_65220  lpd; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBC2_13150  sthA; Soluble pyridine nucleotide transhydrogenase [KO:K00382] [EC:1.8.1.4]
SBC2_22200  lpdG; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SBC2_35360  gcvH; Glycine cleavage system H protein [KO:K02437]
SBC2_54610  Creatinase [KO:K08688] [EC:3.5.3.3]
SBC2_24510  CDP-alcohol phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
SBC2_55170  betA_4; Oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SBC2_60620  betA_5; Oxygen-dependent choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SBC2_55180  betB_2; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SBC2_60640  gbsA_1; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SBC2_80010  gbsA_2; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SBC2_53910  Carnitine monooxygenase oxygenase subunit [KO:K00479] [EC:1.14.13.251]
SBC2_55290  Carnitine monooxygenase oxygenase subunit [KO:K00479] [EC:1.14.13.251]
SBC2_55300  kshB_2; 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component [KO:K21832] [EC:1.14.13.251]
SBC2_55250  stcD_2; putative N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
SBC2_55260  hypothetical protein [KO:K21834]
SBC2_55270  fixB; Protein FixB [KO:K25960]
SBC2_55280  Electron transfer flavoprotein domain protein [KO:K25961]
SBC2_55130  soxA; Sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
SBC2_55110  soxB; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
SBC2_55140  soxG; Sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
SBC2_55120  Sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
SBC2_35390  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
SBC2_55100  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
SBC2_38110  tdcB_1; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
SBC2_61190  tdcB_2; L-threonine dehydratase catabolic TdcB [KO:K01754] [EC:4.3.1.19]
SBC2_03710  ilvA_1; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
SBC2_16630  psdht; Phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
SBC2_63980  ilvA_2; L-threonine dehydratase biosynthetic IlvA [KO:K17989] [EC:4.3.1.17 4.3.1.19]
SBC2_03650  D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
SBC2_56340  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SBC2_56320  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
SBC2_38090  doeA; Ectoine hydrolase [KO:K15783] [EC:3.5.4.44]
SBC2_38080  doeB; N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase [KO:K15784] [EC:3.5.1.125]
SBC2_38050  spuC_2; Putrescine--pyruvate aminotransferase [KO:K15785] [EC:2.6.1.76]
SBC2_69610  spuC_5; Putrescine--pyruvate aminotransferase [KO:K15785] [EC:2.6.1.76]
SBC2_38060  gabD_2; Succinate-semialdehyde dehydrogenase [NADP(+)] GabD [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
caba00010  Glycolysis / Gluconeogenesis
caba00020  Citrate cycle (TCA cycle)
caba00230  Purine metabolism
caba00250  Alanine, aspartate and glutamate metabolism
caba00270  Cysteine and methionine metabolism
caba00290  Valine, leucine and isoleucine biosynthesis
caba00300  Lysine biosynthesis
caba00330  Arginine and proline metabolism
caba00460  Cyanoamino acid metabolism
caba00470  D-Amino acid metabolism
caba00564  Glycerophospholipid metabolism
caba00600  Sphingolipid metabolism
caba00620  Pyruvate metabolism
caba00630  Glyoxylate and dicarboxylate metabolism
caba00640  Propanoate metabolism
caba00680  Methane metabolism
caba00860  Porphyrin metabolism
caba00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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