KEGG   PATHWAY: cang04727
Entry
cang04727                   Pathway                                
Name
GABAergic synapse - Colobus angolensis palliatus (Angola colobus)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
cang04727  GABAergic synapse
cang04727

Other DBs
GO: 0051932
Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105507550  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
105507549  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
105500541  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105507776  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105527500  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
105514521  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
105502500  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
105525699  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
105501401  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
105501405  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
105515798  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
105515799  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
105525479  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
105512422  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
105501403  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
105515797  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105512421  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
105501407  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186]
105515801  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
105512425  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
105525482  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
105525476  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
105515837  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
105521806  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105516624  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105519745  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105502517  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105503488  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105523456  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105524211  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
105503150  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
105523591  GABARAP; gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
105519397  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105514564  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
105520279  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
105517468  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
105517434  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
105517241  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
105502409  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
105501615  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
105511728  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
105511731  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
105519853  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105522784  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105503912  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105515441  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105514987  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105504320  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105509952  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
105513831  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
105501681  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105516095  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105509681  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105525409  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105503945  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105513099  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105519004  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105523712  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105502226  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105525968  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
105512258  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105507261  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105521045  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105520803  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
105521044  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105524588  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105515072  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105510962  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105518129  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105503715  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105517990  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
105507648  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105514953  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105509064  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105525627  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105520351  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
105519085  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
105522583  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
105519201  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
105522584  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
105511905  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
105509682  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
105515023  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
cang00020  Citrate cycle (TCA cycle)
cang00250  Alanine, aspartate and glutamate metabolism
cang04144  Endocytosis
cang04721  Synaptic vesicle cycle
KO pathway
ko04727   
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