KEGG   PATHWAY: ccay00260
Entry
ccay00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Caretta caretta (Loggerhead turtle)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ccay00260  Glycine, serine and threonine metabolism
ccay00260

Module
ccay_M00047  Creatine pathway [PATH:ccay00260]
ccay_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ccay00260]
ccay_M00555  Betaine biosynthesis, choline => betaine [PATH:ccay00260]
ccay_M00621  Glycine cleavage system [PATH:ccay00260]
ccay_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ccay00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Caretta caretta (Loggerhead turtle) [GN:ccay]
Gene
125621261  uncharacterized protein LOC125621261 isoform X1 [KO:K01620] [EC:4.1.2.48]
125627746  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
125644246  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
125642986  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
125637386  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
125637387  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
125639581  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
125639704  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
125626395  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
125625700  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
125641136  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125623970  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
125628589  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
125634711  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
125639939  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
125628188  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
125642893  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125642900  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
125626675  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
125637379  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
125639458  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
125630410  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
125620705  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
125622932  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
125636737  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125644022  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
125627307  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
125639479  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
125636818  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
125636505  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
125636504  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
125623728  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
125623620  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
125633270  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
125643160  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
125643177  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
125640829  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
125639659  L-threonine dehydratase catabolic TdcB-like [KO:K01754] [EC:4.3.1.19]
125622762  L-serine dehydratase/L-threonine deaminase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125623043  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125624044  SRR; LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ccay00010  Glycolysis / Gluconeogenesis
ccay00020  Citrate cycle (TCA cycle)
ccay00230  Purine metabolism
ccay00250  Alanine, aspartate and glutamate metabolism
ccay00270  Cysteine and methionine metabolism
ccay00290  Valine, leucine and isoleucine biosynthesis
ccay00330  Arginine and proline metabolism
ccay00470  D-Amino acid metabolism
ccay00564  Glycerophospholipid metabolism
ccay00600  Sphingolipid metabolism
ccay00620  Pyruvate metabolism
ccay00630  Glyoxylate and dicarboxylate metabolism
ccay00640  Propanoate metabolism
ccay00860  Porphyrin metabolism
ccay00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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