KEGG   PATHWAY: cgib04260
Entry
cgib04260                   Pathway                                
Name
Cardiac muscle contraction - Carassius gibelio (silver crucian carp)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
cgib04260  Cardiac muscle contraction
cgib04260

Other DBs
GO: 0060048
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127956189  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127973732  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
127963129  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
127968377  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
128022121  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
127964170  calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
128018341  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
128018705  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
127963663  calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127987679  calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
128018620  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
127953709  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
127947776  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
127961472  voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
128016436  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
127944565  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
127944786  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
128011118  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
128011305  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
127964447  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
127960198  voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
128015412  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
128020013  voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
127974291  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
127956800  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
127934749  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
127977265  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
127942915  voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
127959340  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
128015996  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
127963142  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
127968378  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
128022123  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
127956880  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127947311  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127951872  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
127960078  calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
127940822  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
128015466  voltage-dependent calcium channel gamma-1 subunit-like isoform X1 [KO:K04866]
127951861  calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
127948971  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
127959422  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
128015303  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
127952906  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127949345  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127950910  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127985664  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
127951825  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
127960076  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
127940731  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
127944433  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
127953426  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
127960077  calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
128015460  voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
127975235  voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
127934987  calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
127978774  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
128030773  voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871]
127974515  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
127935046  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
127978718  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
128030171  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
127975547  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
127935042  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
127978724  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
128030775  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04873]
127976444  ryanodine receptor 2 [KO:K04962]
128025589  ryanodine receptor 2 isoform X1 [KO:K04962]
127961195  uncharacterized abhydrolase domain-containing protein DDB_G0269086 isoform X1 [KO:K00476] [EC:1.14.11.16]
128017691  calponin homology domain-containing protein DDB_G0272472-like isoform X1 [KO:K00476] [EC:1.14.11.16]
127964849  calsequestrin-2 [KO:K23445]
127949651  calsequestrin-2-like [KO:K23445]
128015299  calsequestrin-2-like [KO:K23445]
128019939  calsequestrin-2-like [KO:K23445]
127939034  triadin-like isoform X1 [KO:K23449]
127984305  triadin isoform X1 [KO:K23449]
127941595  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
127952356  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
127963602  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
127957211  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
127948414  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
127949384  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
128024912  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
127985745  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
128017069  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
128007784  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
128018909  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
127944441  troponin C, slow skeletal and cardiac muscles [KO:K05865]
128011574  troponin C type 1b (slow) [KO:K05865]
127944184  troponin T, cardiac muscle isoforms-like [KO:K12045]
127956147  troponin T, cardiac muscle isoforms-like [KO:K12045]
127956452  troponin T, slow skeletal muscle-like isoform X1 [KO:K12045]
127947474  LOW QUALITY PROTEIN: troponin T, cardiac muscle isoforms-like [KO:K12045]
127976166  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
127960008  troponin T, cardiac muscle isoforms [KO:K12045]
127977653  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
128014052  troponin T2d, cardiac [KO:K12045]
128016014  troponin T, cardiac muscle isoforms-like [KO:K12045]
128011979  troponin T, cardiac muscle isoforms-like [KO:K12045]
127961807  tropomyosin alpha-1 chain-like [KO:K10373]
127978924  tropomyosin alpha-3 chain isoform X1 [KO:K10373]
127935180  tropomyosin alpha-3 chain-like isoform X1 [KO:K10373]
127947331  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
128014098  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
128016989  tropomyosin alpha-1 chain [KO:K10373]
127966368  tropomyosin beta chain isoform X1 [KO:K10374]
128021429  tropomyosin beta chain-like isoform X1 [KO:K10374]
127942743  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
127938098  tropomyosin 4b isoform X1 [KO:K10375]
127951105  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
127987911  tropomyosin 4a isoform X1 [KO:K10375]
127970770  actin alpha 1, skeletal muscle b [KO:K12314]
127983981  actin, alpha, cardiac muscle 2 [KO:K12314]
127984180  actin, alpha cardiac muscle 1a [KO:K12314]
127933287  actin, alpha cardiac muscle 1b [KO:K12314]
127947436  actin, alpha cardiac muscle 1-like [KO:K12314]
127949120  actin, alpha skeletal muscle 2-like [KO:K12314]
127976778  actin, alpha skeletal muscle [KO:K12314]
127938823  actin, alpha cardiac muscle 1 [KO:K12314]
127938914  actin, alpha cardiac muscle [KO:K12314]
128014725  beta-actin-like protein 2 [KO:K12314]
128026230  actin, alpha skeletal muscle 2-like [KO:K12314]
128020021  actin, alpha skeletal muscle 2 [KO:K12314]
127938477  myosin-6 [KO:K17751]
127950773  myosin-7-like [KO:K17751]
127950774  myosin-7 [KO:K17751]
128028498  myosin-7-like isoform X1 [KO:K17751]
128028524  myosin-7-like [KO:K17751]
128012824  slow myosin heavy chain 1 [KO:K17751]
127963050  myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
127957130  myosin regulatory light chain 2a [KO:K10351]
128019022  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
127942857  myosin light chain 4 [KO:K12750]
127957160  cardiac myosin light chain-1 [KO:K12750]
127957162  myosin light chain 4-like [KO:K12750]
127969344  myosin light chain 3, skeletal muscle isoform-like [KO:K12750]
128025035  myosin light chain 4-like isoform X1 [KO:K12750]
127988805  myosin light chain 4-like [KO:K12750]
127989724  myosin light chain 4-like [KO:K12750]
127961696  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
127934262  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
127977759  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
128016684  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
9222076  CYTB; cytochrome b [KO:K00412]
127960254  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
128015948  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
128016221  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
127953142  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
127944594  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
127969502  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
128024966  cytochrome b-c1 complex subunit 2, mitochondrial-like isoform X1 [KO:K00415]
127959781  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
128015247  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
127935236  cytochrome b-c1 complex subunit 7-like [KO:K00417]
127978756  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
127971692  cytochrome b-c1 complex subunit 8-like isoform X1 [KO:K00418]
128027466  cytochrome b-c1 complex subunit 8-like [KO:K00418]
127941782  cytochrome b-c1 complex subunit 9-like [KO:K00419]
127986114  cytochrome b-c1 complex subunit 9 [KO:K00419]
127988073  cytochrome b-c1 complex subunit 10 [KO:K00420]
9222070  COX3; cytochrome c oxidase subunit III [KO:K02262]
9222066  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
9222067  COX2; cytochrome c oxidase subunit II [KO:K02261]
127944540  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like isoform X1 [KO:K02263]
127946354  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
127934740  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
128013636  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
127946637  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
127977873  cytochrome c oxidase subunit 5A, mitochondrial isoform X1 [KO:K02264]
128014320  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
127963679  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
127965920  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
127970279  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
128025847  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
128020721  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
127963416  cytochrome c oxidase subunit 6A, mitochondrial-like [KO:K02266]
127953689  cytochrome c oxidase subunit 6A, mitochondrial-like [KO:K02266]
127949341  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
128018452  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
127945872  cytochrome c oxidase subunit 6B1-like [KO:K02267]
127974623  cytochrome c oxidase subunit 6B1 [KO:K02267]
128013568  cytochrome c oxidase subunit 6B1 [KO:K02267]
128031131  cytochrome c oxidase subunit 6B1-like [KO:K02267]
127959916  cytochrome c oxidase subunit 6C-1-like [KO:K02268]
128015971  cytochrome c oxidase subunit 6C-1 [KO:K02268]
127970737  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
127983475  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
127983478  cytochrome c oxidase subunit 7A2, mitochondrial-like isoform X1 [KO:K02270]
127976467  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
127969056  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like isoform X1 [KO:K02270]
128031368  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
128025270  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
128026474  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
128029274  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
127941914  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
127986382  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
127957133  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
127987892  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
127941961  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
127947369  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
128014547  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
127984295  si:dkey-85n7.8; COX8 domain-containing protein [KO:K02273]
127986589  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
127961711  solute carrier family 8 member 4b [KO:K05849]
127970774  sodium/calcium exchanger 3 isoform X1 [KO:K05849]
127942370  solute carrier family 8 member 4a [KO:K05849]
127933261  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
127972942  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127957754  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127967808  sodium/calcium exchanger 1a isoform X1 [KO:K05849]
127976295  sodium/calcium exchanger 1b isoform X1 [KO:K05849]
128022208  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
128026031  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
128004872  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
128029520  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
127971635  sodium/hydrogen exchanger 6-like [KO:K12041]
127966837  sodium/hydrogen exchanger 6-like [KO:K12041]
127959336  sodium/hydrogen exchanger 7-like isoform X1 [KO:K12041]
128021174  sodium/hydrogen exchanger 6-like [KO:K12041]
128015707  sodium/hydrogen exchanger 7 isoform X1 [KO:K12041]
128027255  sodium/hydrogen exchanger 6-like [KO:K12041]
127979328  sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
127974388  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
127934746  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
127935626  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
127948930  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
127948931  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
127948932  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
127950903  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
128030739  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
128012821  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
128019995  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
128012895  sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
127979057  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
127971977  protein ATP1B4 isoform X1 [KO:K01540]
127944898  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
127972886  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
127958740  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
127949216  sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
127959786  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
127950526  sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
128015589  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
128026987  sodium/potassium-transporting ATPase subunit beta-3-like isoform X1 [KO:K01540]
128027206  protein ATP1B4-like isoform X1 [KO:K01540]
128003574  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
128011484  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
128028728  sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
127957936  sodium/potassium-transporting ATPase subunit gamma-like [KO:K01538]
127987958  sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
127974998  sodium/hydrogen exchanger 1-like [KO:K05742]
127935208  sodium/hydrogen exchanger 1b [KO:K05742]
128030322  sodium/hydrogen exchanger 1-like [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
cgib04020  Calcium signaling pathway
KO pathway
ko04260   
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