KEGG   PATHWAY: chx04612
Entry
chx04612                    Pathway                                
Name
Antigen processing and presentation - Capra hircus (goat)
Class
Organismal Systems; Immune system
Pathway map
chx04612  Antigen processing and presentation
chx04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Capra hircus (goat) [GN:chx]
Gene
100860815  IFNG; interferon gamma precursor [KO:K04687]
100861232  TNF; tumor necrosis factor [KO:K03156]
102179390  PSME1; proteasome activator complex subunit 1 [KO:K06696]
102191527  PSME2; proteasome activator complex subunit 2 isoform X1 [KO:K06697]
102191267  PSME3; proteasome activator complex subunit 3 [KO:K06698]
102177850  heat shock 70 kDa protein 1-like [KO:K03283]
102178315  heat shock 70 kDa protein 1B [KO:K03283]
102182240  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102185412  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100860849  HSP70.1; heat shock protein 70.1 [KO:K03283]
102186695  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102172434  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100860851  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100861006  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102172138  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102180584  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102188814  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
102181202  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
108633459  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
108633460  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102183314  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102176782  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102170045  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102168905  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102169753  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102185917  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102181347  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
108633505  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102175817  patr class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102171703  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102185663  HSPA5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
102173831  CANX; calnexin [KO:K08054]
102168267  B2M; beta-2-microglobulin [KO:K08055]
102168547  beta-2-microglobulin [KO:K08055]
100860882  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
102185733  CALR; calreticulin [KO:K08057]
102191658  TAPBP; tapasin [KO:K08058]
102181173  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102180638  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102185010  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
102184733  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
108638096  putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 [KO:K07980]
102189064  LOW QUALITY PROTEIN: putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
108638053  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
102189305  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
106503874  LOW QUALITY PROTEIN: putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
102190217  putative killer cell immunoglobulin-like receptor like protein KIR3DP1 [KO:K07980]
102168342  LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 2DL4 [KO:K24231]
102182856  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
102182286  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
102182573  NKG2-A/NKG2-B type II integral membrane protein [KO:K06541]
102183669  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
108636058  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
102172697  natural killer cells antigen CD94 [KO:K06516]
102184229  natural killer cells antigen CD94 [KO:K06516]
106502275  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
102191183  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
102173295  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
102180664  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1 [KO:K06752]
102179937  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
102187356  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
102190745  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102188267  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102188986  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102187998  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102186727  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
106503481  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
102186442  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102189356  HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
100860813  HA25 [KO:K06752]
102185560  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
102185465  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102190225  CTSV; cathepsin L2 precursor [KO:K01365] [EC:3.4.22.15]
102183747  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
102170124  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
102172509  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102171562  RFX5; DNA-binding protein RFX5 [KO:K08061]
102189385  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
102185753  RFXAP; regulatory factor X-associated protein [KO:K08063]
102186065  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102187277  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
102182108  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
102183386  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
chx03050  Proteasome
chx04650  Natural killer cell mediated cytotoxicity
chx04660  T cell receptor signaling pathway
KO pathway
ko04612   
LinkDB

DBGET integrated database retrieval system