KEGG   PATHWAY: cill00270
Entry
cill00270                   Pathway                                
Name
Cysteine and methionine metabolism - Carya illinoinensis (pecan)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
cill00270  Cysteine and methionine metabolism
cill00270

Module
cill_M00021  Cysteine biosynthesis, serine => cysteine [PATH:cill00270]
cill_M00034  Methionine salvage pathway [PATH:cill00270]
cill_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:cill00270]
Other DBs
GO: 0006534 0006555
Organism
Carya illinoinensis (pecan) [GN:cill]
Gene
122277641  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122315615  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
122282077  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122304385  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
122300573  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
122281174  cysteine synthase 2 isoform X1 [KO:K01738] [EC:2.5.1.47]
122315141  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122315299  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122315300  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122315849  cysteine synthase [KO:K01738] [EC:2.5.1.47]
122275362  cysteine synthase [KO:K01738] [EC:2.5.1.47]
122310197  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial isoform X1 [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122276471  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
122295665  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
122278353  homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
122300779  homocysteine S-methyltransferase 3-like isoform X1 [KO:K00547] [EC:2.1.1.10]
122279191  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
122292161  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
122275873  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
122276361  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
122316042  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
122316595  S-adenosylmethionine synthase 4-like [KO:K00789] [EC:2.5.1.6]
122317048  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
122318799  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
122296465  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122313662  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122300487  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
122274397  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
122308226  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122302275  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
122309808  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
122311531  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122313530  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
122313684  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122280891  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122290203  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
122316727  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122317470  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122318255  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122313164  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122309783  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
122309784  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
122304263  methylthioribose-1-phosphate isomerase isoform X1 [KO:K08963] [EC:5.3.1.23]
122281741  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122290091  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122278127  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122300767  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122311076  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
122314053  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
122281928  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122307496  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
122307497  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122307847  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122307879  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
122301086  aromatic aminotransferase ISS1 isoform X1 [KO:K00837] [EC:2.6.1.-]
122282815  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
122282621  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122290250  methionine gamma-lyase-like isoform X1 [KO:K01761] [EC:4.4.1.11]
122282964  DNA (cytosine-5)-methyltransferase CMT2 [KO:K00558] [EC:2.1.1.37]
122289136  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
122291962  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
122318371  uncharacterized protein LOC122318371 [KO:K17398] [EC:2.1.1.37]
122300255  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122315734  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
122310394  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122280401  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122301974  1-aminocyclopropane-1-carboxylate synthase-like isoform X1 [KO:K20772] [EC:4.4.1.14]
122290190  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122315266  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122316924  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122317042  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122305698  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122319290  1-aminocyclopropane-1-carboxylate synthase CMA101-like [KO:K01762] [EC:4.4.1.14]
122307921  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122277003  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
122278838  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
122296583  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122297334  1-aminocyclopropane-1-carboxylate oxidase 5-like isoform X1 [KO:K05933] [EC:1.14.17.4]
122299126  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122303752  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
122306565  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
122306785  1-aminocyclopropane-1-carboxylate oxidase 3-like [KO:K05933] [EC:1.14.17.4]
122306815  1-aminocyclopropane-1-carboxylate oxidase 3-like [KO:K05933] [EC:1.14.17.4]
122308268  1-aminocyclopropane-1-carboxylate oxidase 3-like [KO:K05933] [EC:1.14.17.4]
122308269  1-aminocyclopropane-1-carboxylate oxidase 3-like [KO:K05933] [EC:1.14.17.4]
122308398  1-aminocyclopropane-1-carboxylate oxidase 3-like isoform X1 [KO:K05933] [EC:1.14.17.4]
122302227  aspartokinase 3, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
122308817  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
122302350  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
122307790  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
122314417  aspartate-semialdehyde dehydrogenase isoform X1 [KO:K00133] [EC:1.2.1.11]
122302435  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122307662  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122296401  branched-chain amino acid aminotransferase 1, mitochondrial isoform X1 [KO:K00826] [EC:2.6.1.42]
122311416  branched-chain-amino-acid aminotransferase 6-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122315510  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122279871  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122303563  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122291047  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122275744  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122280360  glutamate--cysteine ligase, chloroplastic-like isoform X1 [KO:K01919] [EC:6.3.2.2]
122289893  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
122317921  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
122316940  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
122319033  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122279969  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
122304151  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
122308160  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
122315746  aspartate aminotransferase P2, mitochondrial isoform X1 [KO:K00811] [EC:2.6.1.1]
122318211  LOW QUALITY PROTEIN: aspartate aminotransferase P2, mitochondrial-like [KO:K00811] [EC:2.6.1.1]
122281580  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122280633  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
122290341  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
122311956  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
122298575  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like isoform X1 [KO:K05396] [EC:4.4.1.15]
122298576  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
122314732  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122316054  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122316722  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
122277016  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
122300681  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
122292290  malate dehydrogenase-like isoform X1 [KO:K00025] [EC:1.1.1.37]
122280792  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
122281637  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
122316792  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
122289519  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122319374  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
122276008  cysteine synthase-like isoform X1 [KO:K22846] [EC:2.5.1.144]
122279585  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122313304  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122309075  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122315383  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
122319270  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
cill00010  Glycolysis / Gluconeogenesis
cill00250  Alanine, aspartate and glutamate metabolism
cill00260  Glycine, serine and threonine metabolism
cill00290  Valine, leucine and isoleucine biosynthesis
cill00430  Taurine and hypotaurine metabolism
cill00480  Glutathione metabolism
cill00620  Pyruvate metabolism
cill00640  Propanoate metabolism
cill00770  Pantothenate and CoA biosynthesis
cill00900  Terpenoid backbone biosynthesis
cill00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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