KEGG   PATHWAY: cjc04390
Entry
cjc04390                    Pathway                                
Name
Hippo signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04390  Hippo signaling pathway
cjc04390

Other DBs
GO: 0035329
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100392496  CRB2; protein crumbs homolog 2 isoform X1 [KO:K16681]
100385306  CRB1; protein crumbs homolog 1 [KO:K16681]
100393064  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100403482  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100388182  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
100391194  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
100394749  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
100399514  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100409152  PATJ; inaD-like protein isoform X22 [KO:K06092]
100398752  PALS1; protein PALS1 isoform X1 [KO:K06091]
100400029  AMOT; angiomotin isoform X1 [KO:K16819]
100393920  YAP1; transcriptional coactivator YAP1 isoform X4 [KO:K16687]
100401831  WWTR1; WW domain-containing transcription regulator protein 1 isoform X2 [KO:K16820]
100398679  CDH1; cadherin-1 [KO:K05689]
100399549  WTIP; Wilms tumor protein 1-interacting protein [KO:K16682]
100392345  AJUBA; LIM domain-containing protein ajuba isoform X1 [KO:K16682]
100394908  LIMD1; LIM domain-containing protein 1 [KO:K16682]
100413257  NF2; merlin isoform X1 [KO:K16684]
100413386  WWC1; protein KIBRA isoform X1 [KO:K16685]
100396879  FRMD1; LOW QUALITY PROTEIN: FERM domain-containing protein 1 [KO:K16821]
100391018  FRMD6; FERM domain-containing protein 6 isoform X1 [KO:K16822]
100415144  SAV1; protein salvador homolog 1 [KO:K16686]
100387692  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
100390956  RASSF6; ras association domain-containing protein 6 isoform X1 [KO:K09854]
100407858  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100395261  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100398536  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100408674  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100413664  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100385385  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100407485  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
100407627  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
100386371  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
100410314  LATS1; serine/threonine-protein kinase LATS1 isoform X1 [KO:K08791] [EC:2.7.11.1]
100414392  LATS2; serine/threonine-protein kinase LATS2 isoform X1 [KO:K08791] [EC:2.7.11.1]
100402887  MOB1A; MOB kinase activator 1A isoform X1 [KO:K06685]
103792004  MOB1B; MOB kinase activator 1B isoform X7 [KO:K06685]
100410496  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
100396453  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100394435  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100391612  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
100402258  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100404852  TP53BP2; apoptosis-stimulating of p53 protein 2 isoform X2 [KO:K16823]
100395080  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100389428  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
100407391  SCRIB; protein scribble homolog isoform X2 [KO:K16175]
100401687  DLG1; disks large homolog 1 isoform X23 [KO:K12076]
100414556  DLG2; disks large homolog 2 isoform X23 [KO:K12075]
100413310  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
100398576  DLG4; disks large homolog 4 isoform X7 [KO:K11828]
100401919  DLG5; LOW QUALITY PROTEIN: disks large homolog 5 [KO:K24050]
100395325  CSNK1D; casein kinase I isoform X2 [KO:K08959] [EC:2.7.11.1]
100407384  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
100389218  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
100402300  FBXW11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
100393670  TP73; tumor protein p73 isoform X1 [KO:K10148]
100387604  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
100396329  TEAD1; transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
100412927  TEAD3; transcriptional enhancer factor TEF-5 isoform X1 [KO:K09448]
100409116  TEAD2; transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
100386200  TEAD4; transcriptional enhancer factor TEF-3 isoform X1 [KO:K09448]
100412819  CCN2; CCN family member 2 [KO:K06827]
100413916  GLI2; zinc finger protein GLI2 isoform X1 [KO:K16798]
118149682  LOW QUALITY PROTEIN: zinc finger protein GLI2-like [KO:K16798]
100387931  AREG; amphiregulin [KO:K09782]
100398121  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X2 [KO:K08731]
100391306  AFP; alpha-fetoprotein [KO:K16144]
100402685  ITGB2; integrin beta-2 isoform X2 [KO:K06464]
100392014  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100401979  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100392463  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100389596  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100404359  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100405407  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
100396826  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100393808  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
100409302  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100385528  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
100408260  BMP2; bone morphogenetic protein 2 [KO:K21283]
100398270  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
100407531  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
100396509  BMP6; bone morphogenetic protein 6 [KO:K16620]
100402827  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
100398735  BMP8A; bone morphogenetic protein 8A isoform X5 [KO:K16622]
100393400  GDF5; growth/differentiation factor 5 [KO:K04664]
118148537  GDF6; growth/differentiation factor 6 [KO:K20012]
100389360  GDF7; growth/differentiation factor 7 [KO:K20013]
100406441  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
100402757  BMPR1A; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
100397724  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
100402963  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100402435  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
100412122  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100408338  ID2; DNA-binding protein inhibitor ID-2 isoform X2 [KO:K17693]
100389319  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100395234  WNT2B; protein Wnt-2b [KO:K00182]
100411308  WNT2; protein Wnt-2 [KO:K00182]
100385309  WNT3A; protein Wnt-3a [KO:K00312]
100398579  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100387135  WNT4; protein Wnt-4 [KO:K00408]
100401066  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
100405273  WNT5B; protein Wnt-5b [KO:K00444]
100394855  WNT6; protein Wnt-6 [KO:K00445]
100414221  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
100387909  WNT7A; protein Wnt-7a [KO:K00572]
100414921  WNT8B; protein Wnt-8b [KO:K00714]
100402422  WNT8A; protein Wnt-8a [KO:K00714]
100397032  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
100393646  WNT9B; protein Wnt-9b [KO:K01064]
100395222  WNT10A; protein Wnt-10a [KO:K01357]
100388949  WNT10B; protein Wnt-10b [KO:K01357]
100398625  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
100387388  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100401631  FZD7; frizzled-7 [KO:K02432]
100404550  FZD1; frizzled-1 [KO:K02432]
100409481  FZD2; frizzled-2 [KO:K02235]
100396334  FZD3; frizzled-3 isoform X1 [KO:K02329]
100403228  FZD4; frizzled-4 isoform X1 [KO:K02354]
100410939  FZD5; frizzled-5 [KO:K02375]
100398598  FZD8; frizzled-8 [KO:K02375]
100387077  FZD6; frizzled-6 [KO:K02376]
100403975  FZD9; frizzled-9 [KO:K02842]
100398976  FZD10; frizzled-10 [KO:K02842]
100390081  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100398229  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100388569  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X3 [KO:K02353]
118154524  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
100405784  YWHAQ; 14-3-3 protein theta [KO:K16197]
100411134  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100405841  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100408751  14-3-3 protein theta-like [KO:K16197]
118143745  14-3-3 protein zeta/delta-like [KO:K16197]
100390011  uncharacterized protein LOC100390011 [KO:K06630]
100400280  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100402417  YWHAH; 14-3-3 protein eta [KO:K16198]
100408839  YWHAG; 14-3-3 protein gamma [KO:K16198]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100397972  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100385653  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100392475  AXIN1; axin-1 isoform X1 [KO:K02157]
100400518  AXIN2; axin-2 isoform X1 [KO:K04385]
100395772  NKD2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
100405821  NKD1; protein naked cuticle homolog 1 [KO:K03213]
100399154  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100403963  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
100406757  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100399759  LEF1; lymphoid enhancer-binding factor 1 isoform X5 [KO:K04492]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100407856  SOX2; transcription factor SOX-2 [KO:K16796]
100404347  SNAI2; zinc finger protein SNAI2 [KO:K05706]
100394418  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100399118  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100398645  actin, cytoplasmic 2-like [KO:K05692]
100404409  actin, cytoplasmic 1-like [KO:K05692]
100406907  actin, cytoplasmic 2-like [KO:K05692]
100410882  actin, cytoplasmic 2-like [KO:K05692]
100412618  actin, cytoplasmic 1 [KO:K05692]
100409006  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100388094  actin, cytoplasmic 2 [KO:K05692]
100406296  ACTB; actin, cytoplasmic 1 [KO:K05692]
100401391  actin, cytoplasmic 2-like [KO:K05692]
118150586  actin, cytoplasmic 2-like [KO:K05692]
100390556  CTNNA2; catenin alpha-2 isoform X6 [KO:K05691]
100396596  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
100407624  CTNNA1; catenin alpha-1 isoform X2 [KO:K05691]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
cjc04120  Ubiquitin mediated proteolysis
cjc04310  Wnt signaling pathway
cjc04350  TGF-beta signaling pathway
cjc04520  Adherens junction
cjc04530  Tight junction
KO pathway
ko04390   
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