KEGG   PATHWAY: cjc04350
Entry
cjc04350                    Pathway                                
Name
TGF-beta signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04350  TGF-beta signaling pathway
cjc04350

Other DBs
GO: 0007179
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385326  EMP3; epithelial membrane protein 3 [KO:K26257]
100385583  RGMA; repulsive guidance molecule A isoform X1 [KO:K23096]
100385847  NEO1; neogenin isoform X4 [KO:K06766]
100386392  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
100386632  HAMP; hepcidin [KO:K23106]
100388952  IFNG; interferon gamma precursor [KO:K04687]
100389244  ACVR2B; LOW QUALITY PROTEIN: activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
100389360  GDF7; growth/differentiation factor 7 [KO:K20013]
100389459  SMAD6; mothers against decapentaplegic homolog 6 isoform X2 [KO:K04677]
100389596  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100390101  RGMB; repulsive guidance molecule B [KO:K06847]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100390471  HFE; hereditary hemochromatosis protein isoform X2 [KO:K26535]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100391128  FBN1; fibrillin-1 isoform X1 [KO:K06825]
100391237  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
100391523  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100391614  ACVR1B; activin receptor type-1B isoform X2 [KO:K13567] [EC:2.7.11.30]
100392363  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100392443  NBL1; neuroblastoma suppressor of tumorigenicity 1 isoform X2 [KO:K19558]
100392463  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100392632  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
100393048  IGSF1; immunoglobulin superfamily member 1 isoform X1 [KO:K26168]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100393400  GDF5; growth/differentiation factor 5 [KO:K04664]
100393808  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
100394652  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
100395261  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100395278  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100395702  CUL1; cullin-1 [KO:K03347]
100395820  NOG; noggin [KO:K04658]
100395993  TFR2; transferrin receptor protein 2 isoform X2 [KO:K23910]
100395994  SKIL; ski-like protein isoform X1 [KO:K18499]
100396487  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
100396509  BMP6; bone morphogenetic protein 6 [KO:K16620]
100396826  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100397056  LRRC32; transforming growth factor beta activator LRRC32 isoform X2 [KO:K26316]
100397180  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100397472  HJV; hemojuvelin [KO:K23100]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397724  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
100397767  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
100398187  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100398270  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
100398536  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100398735  BMP8A; bone morphogenetic protein 8A isoform X5 [KO:K16622]
100399690  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100399978  CHRD; chordin isoform X1 [KO:K04657]
100400410  TMEM53; transmembrane protein 53 isoform X1 [KO:K28359]
100400417  INHBA; LOW QUALITY PROTEIN: inhibin beta A chain [KO:K04667]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100400784  INHBC; inhibin beta C chain [KO:K22688]
100401148  INHBE; inhibin beta E chain isoform X2 [KO:K22689]
100401228  [KO:K06067] [EC:3.5.1.98]
100401264  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
100401905  GREM1; gremlin-1 [KO:K23318]
100401979  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100402143  LEMD3; inner nuclear membrane protein Man1 isoform X2 [KO:K19410]
100402327  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100402364  SKI; ski oncogene isoform X1 [KO:K26503]
100402435  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
100402757  BMPR1A; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
100402827  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
100402963  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100403271  TF; serotransferrin [KO:K14736]
100404129  [KO:K04513]
100404359  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100404471  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100404916  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100405004  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
100405037  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100405391  DCN; decorin [KO:K04660]
100405407  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
100406186  GREM2; gremlin-2 [KO:K23318]
100406441  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
100406595  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
100406643  NODAL; nodal homolog isoform X1 [KO:K04666]
100407436  ACVR1C; activin receptor type-1C isoform X2 [KO:K13568] [EC:2.7.11.30]
100407510  TFRC; transferrin receptor protein 1 [KO:K06503]
100407531  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100407824  SP1; transcription factor Sp1 isoform X3 [KO:K04684]
100408003  [KO:K04668]
100408176  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
100408187  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
100408260  BMP2; bone morphogenetic protein 2 [KO:K21283]
100408338  ID2; DNA-binding protein inhibitor ID-2 isoform X2 [KO:K17693]
100408674  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100408823  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
100408978  [KO:K04668]
100409088  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
100409247  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
100409302  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100409816  FMOD; fibromodulin [KO:K08121]
100410315  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100410965  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
100412120  [KO:K19553]
100412122  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100412680  FST; follistatin isoform X1 [KO:K04661]
100413195  INHBB; inhibin beta B chain [KO:K22687]
100413245  TFDP1; transcription factor Dp-1 [KO:K04683]
100413664  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100413890  E2F4; transcription factor E2F4 isoform X2 [KO:K04682]
100414523  [KO:K03094]
100414861  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
100415191  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
100415541  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
100415659  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
103787201  TGIF2; homeobox protein TGIF2 [KO:K19553]
103792242  ID4; DNA-binding protein inhibitor ID-4 isoform X1 [KO:K17695]
103796394  [KO:K03868] [EC:2.3.2.32]
118148537  GDF6; growth/differentiation factor 6 [KO:K20012]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
cjc04010  MAPK signaling pathway
cjc04110  Cell cycle
cjc04120  Ubiquitin mediated proteolysis
cjc04210  Apoptosis
KO pathway
ko04350   

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