KEGG   PATHWAY: clud00270
Entry
clud00270                   Pathway                                
Name
Cysteine and methionine metabolism - Canis lupus dingo (dingo)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
clud00270  Cysteine and methionine metabolism
clud00270

Module
clud_M00034  Methionine salvage pathway [PATH:clud00270]
clud_M00035  Methionine degradation [PATH:clud00270]
clud_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:clud00270]
Other DBs
GO: 0006534 0006555
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112641069  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
112677290  KYAT1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
112640921  KYAT3; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
112651104  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
112653426  BHMT; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
112653284  BHMT2; S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform X1 [KO:K00547] [EC:2.1.1.10]
112660797  MTR; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
112651524  MAT1A; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
112651722  MAT2B; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
112664314  MAT2A; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
112658369  AMD1; S-adenosylmethionine decarboxylase proenzyme isoform X1 [KO:K01611] [EC:4.1.1.50]
112654987  LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
112678100  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
112654131  SMS; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
112649861  S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
112678849  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
112666603  MRI1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
112663463  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
112646388  ENOPH1; enolase-phosphatase E1 isoform X2 [KO:K09880] [EC:3.1.3.77]
112664912  ADI1; acireductone dioxygenase isoform X2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
112646602  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
112645120  IL4I1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
112642246  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
112641604  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
112666489  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X2 [KO:K00558] [EC:2.1.1.37]
112664687  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
112673795  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X2 [KO:K17399] [EC:2.1.1.37]
112640694  AHCYL1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
112675073  AHCYL2; adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
112673837  AHCY; adenosylhomocysteinase isoform X1 [KO:K01251] [EC:3.13.2.1]
112645184  BCAT2; branched-chain-amino-acid aminotransferase, mitochondrial isoform X1 [KO:K00826] [EC:2.6.1.42]
112665529  BCAT1; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
112652638  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
112641764  GCLC; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
112640843  GCLM; glutamate--cysteine ligase regulatory subunit [KO:K11205]
112673855  GSS; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
112659627  CDO1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
112647995  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
112672175  GOT1; aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
112659960  GOT2; aspartate aminotransferase, mitochondrial isoform X2 [KO:K14455] [EC:2.6.1.1]
112668496  MPST; 3-mercaptopyruvate sulfurtransferase isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
112668506  TST; thiosulfate sulfurtransferase isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
112644351  LDHAL6B; L-lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
112657190  L-lactate dehydrogenase A chain-like isoform X1 [KO:K00016] [EC:1.1.1.27]
112667722  LDHA; L-lactate dehydrogenase A chain isoform X2 [KO:K00016] [EC:1.1.1.27]
112667723  L-lactate dehydrogenase C chain isoform X1 [KO:K00016] [EC:1.1.1.27]
112678459  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
112649398  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
112662359  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
112651742  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
112665507  LDHB; L-lactate dehydrogenase B chain isoform X1 [KO:K00016] [EC:1.1.1.27]
112678754  LOW QUALITY PROTEIN: L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
112673323  LOW QUALITY PROTEIN: L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
112644163  L-lactate dehydrogenase B chain-like [KO:K00016] [EC:1.1.1.27]
112678374  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
112673467  MDH1; malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
112655764  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
112646170  MDH2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
112669446  LOW QUALITY PROTEIN: malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
112664941  LOW QUALITY PROTEIN: malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
112654398  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
112676596  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
112676597  SDSL; serine dehydratase-like isoform X3 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
112664089  D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112664099  D-3-phosphoglycerate dehydrogenase-like isoform X2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112664106  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112644681  phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
clud00010  Glycolysis / Gluconeogenesis
clud00250  Alanine, aspartate and glutamate metabolism
clud00260  Glycine, serine and threonine metabolism
clud00290  Valine, leucine and isoleucine biosynthesis
clud00430  Taurine and hypotaurine metabolism
clud00480  Glutathione metabolism
clud00620  Pyruvate metabolism
clud00640  Propanoate metabolism
clud00770  Pantothenate and CoA biosynthesis
clud00900  Terpenoid backbone biosynthesis
clud00920  Sulfur metabolism
KO pathway
ko00270   
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