KEGG   PATHWAY: cpic04216
Entry
cpic04216                   Pathway                                
Name
Ferroptosis - Chrysemys picta (western painted turtle)
Description
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class
Cellular Processes; Cell growth and death
Pathway map
cpic04216  Ferroptosis
cpic04216

Other DBs
GO: 0097707
Organism
Chrysemys picta (western painted turtle) [GN:cpic]
Gene
101937381  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
101950217  cystine/glutamate transporter-like [KO:K13869]
101949927  cystine/glutamate transporter-like isoform X2 [KO:K13869]
101937035  SLC7A11; cystine/glutamate transporter isoform X1 [KO:K13869]
101942845  TP53; cellular tumor antigen p53 [KO:K04451]
101935836  GCLC; glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
101945231  GCLM; glutamate--cysteine ligase regulatory subunit [KO:K11205]
101933704  GSS; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
101944764  GPX4; phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
101942555  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X2 [KO:K01897] [EC:6.2.1.3]
101950016  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
101942204  ACSL5; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
101949613  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X4 [KO:K01897] [EC:6.2.1.3]
101947978  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
101944358  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101943129  thialysine N-epsilon-acetyltransferase-like isoform X1 [KO:K00657] [EC:2.3.1.57]
101942510  SATL1; spermidine/spermine N(1)-acetyltransferase-like protein 1 [KO:K00657] [EC:2.3.1.57]
101937171  thialysine N-epsilon-acetyltransferase-like isoform X2 [KO:K00657] [EC:2.3.1.57]
103307106  thialysine N-epsilon-acetyltransferase-like isoform X1 [KO:K00657] [EC:2.3.1.57]
101934547  SAT1; diamine acetyltransferase 1 isoform X2 [KO:K00657] [EC:2.3.1.57]
101947049  TF; serotransferrin [KO:K14736]
101936345  TFRC; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
101935674  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
101953240  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
101936280  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
101941154  SLC39A14; metal cation symporter ZIP14 [KO:K14720]
101943982  PCBP2; poly(rC)-binding protein 2 isoform X4 [KO:K13162]
101948998  SLC40A1; solute carrier family 40 member 1 isoform X1 [KO:K14685]
101951863  solute carrier family 40 member 1-like [KO:K14685]
101933863  ceruloplasmin [KO:K13624] [EC:1.16.3.1]
101937621  ferritin heavy chain A [KO:K00522] [EC:1.16.3.1]
101937908  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101938174  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101938710  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101938985  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101939527  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101939802  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101937984  ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
101939003  ferritin light chain, oocyte isoform-like [KO:K00522] [EC:1.16.3.1]
101938449  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101937990  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
101949489  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101953339  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101945912  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
101933581  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
101940365  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101949990  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
101953161  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X4 [KO:K08337]
101943210  NCOA4; nuclear receptor coactivator 4 isoform X2 [KO:K09289]
101932649  major prion protein homolog [KO:K05634]
101950994  HMOX1; LOW QUALITY PROTEIN: heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
101951352  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101947465  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101949220  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00032  Heme
C00051  Glutathione
C00097  L-Cysteine
C00127  Glutathione disulfide
C00129  Isopentenyl diphosphate
C00219  Arachidonate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00491  L-Cystine
C00669  gamma-L-Glutamyl-L-cysteine
C02249  Arachidonyl-CoA
C02477  alpha-Tocopherol
C11378  Ubiquinone-10
C14818  Fe2+
C14819  Fe3+
C16170  (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C16527  Adrenic acid
C16844  Hydroxyl radical
C21478  Erastin
C21479  RSL3
C21480  1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21481  1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21482  1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21483  1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21484  1-Octadecanoyl-sn-glycero-3-phosphoethanolamine
D00448  Sulfasalazine (USP/INN)
D08524  Sorafenib (USAN/INN)
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:26653790
  Authors
Yang WS, Stockwell BR
  Title
Ferroptosis: Death by Lipid Peroxidation.
  Journal
Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014
Reference
PMID:27842066
  Authors
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
  Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
  Journal
Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238
Reference
PMID:27842067
  Authors
D'Herde K, Krysko DV
  Title
Ferroptosis: Oxidized PEs trigger death.
  Journal
Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261
Reference
PMID:28082232
  Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
  Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
  Journal
Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004
Reference
PMID:26725301
  Authors
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
  Title
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
  Journal
Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012
Reference
PMID:26794443
  Authors
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
  Title
Ferroptosis: process and function.
  Journal
Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158
Reference
PMID:27791175
  Authors
Murphy ME
  Title
Ironing out how p53 regulates ferroptosis.
  Journal
Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113
Reference
PMID:28129536
  Authors
Muckenthaler MU, Rivella S, Hentze MW, Galy B
  Title
A Red Carpet for Iron Metabolism.
  Journal
Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034
Reference
PMID:27860262
  Authors
Yu H, Guo P, Xie X, Wang Y, Chen G
  Title
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
  Journal
J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008
Reference
PMID:27314071
  Authors
Wang SJ, Ou Y, Jiang L, Gu W
  Title
Ferroptosis: A missing puzzle piece in the p53 blueprint?
  Journal
Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581
Reference
PMID:27048822
  Authors
Cao JY, Dixon SJ
  Title
Mechanisms of ferroptosis.
  Journal
Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1
Reference
PMID:26436293
  Authors
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
  Title
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
  Journal
Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308
Reference
PMID:28066232
  Authors
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
  Title
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
  Journal
Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308
Reference
PMID:26405158
  Authors
Kwon MY, Park E, Lee SJ, Chung SW
  Title
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
  Journal
Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162
Reference
PMID:22632964
  Authors
Reed JC, Pellecchia M
  Title
Ironing out cell death mechanisms.
  Journal
Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009
Related
pathway
cpic00480  Glutathione metabolism
cpic00900  Terpenoid backbone biosynthesis
KO pathway
ko04216   
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