KEGG   PATHWAY: cpoc00260
Entry
cpoc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cavia porcellus (domestic guinea pig)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpoc00260  Glycine, serine and threonine metabolism
cpoc00260

Module
cpoc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cpoc00260]
cpoc_M00047  Creatine pathway [PATH:cpoc00260]
cpoc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cpoc00260]
cpoc_M00555  Betaine biosynthesis, choline => betaine [PATH:cpoc00260]
cpoc_M00621  Glycine cleavage system [PATH:cpoc00260]
cpoc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cpoc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100731358  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
100733584  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
100725949  Shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
100732498  Agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100713105  Grhpr; glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100715727  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
100718830  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
100728679  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
100722842  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
100726801  Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100731576  Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100719583  Psph; phosphoserine phosphatase isoform X2 [KO:K01079] [EC:3.1.3.3]
100723646  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
100717060  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
100721933  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
100723853  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
100733580  LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
100714848  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100135573  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100721976  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
100720137  LOW QUALITY PROTEIN: primary amine oxidase, lung isozyme-like [KO:K00276] [EC:1.4.3.21]
100714862  Gldc; LOW QUALITY PROTEIN: glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
100729673  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
100721798  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100721850  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
100192327  Dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100714301  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100714491  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
100735222  Gamt; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
100725002  Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
100732238  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100724631  Bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100724353  Dmgdh; dimethylglycine dehydrogenase, mitochondrial isoform X2 [KO:K00315] [EC:1.5.8.4]
100720520  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100718504  Sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
100717389  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
100734876  Cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
100720299  Cth; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
100718435  Sds; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100718716  Sdsl; serine dehydratase-like isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100715409  Srr; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpoc00010  Glycolysis / Gluconeogenesis
cpoc00020  Citrate cycle (TCA cycle)
cpoc00230  Purine metabolism
cpoc00250  Alanine, aspartate and glutamate metabolism
cpoc00270  Cysteine and methionine metabolism
cpoc00290  Valine, leucine and isoleucine biosynthesis
cpoc00330  Arginine and proline metabolism
cpoc00470  D-Amino acid metabolism
cpoc00564  Glycerophospholipid metabolism
cpoc00600  Sphingolipid metabolism
cpoc00620  Pyruvate metabolism
cpoc00630  Glyoxylate and dicarboxylate metabolism
cpoc00640  Propanoate metabolism
cpoc00860  Porphyrin metabolism
cpoc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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