KEGG   PATHWAY: dgt00260
Entry
dgt00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Dendronephthya gigantea (soft corals)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
dgt00260  Glycine, serine and threonine metabolism
dgt00260

Module
dgt_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:dgt00260]
dgt_M00047  Creatine pathway [PATH:dgt00260]
dgt_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:dgt00260]
dgt_M00555  Betaine biosynthesis, choline => betaine [PATH:dgt00260]
dgt_M00621  Glycine cleavage system [PATH:dgt00260]
dgt_M00974  Betaine metabolism, animals, betaine => glycine [PATH:dgt00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Dendronephthya gigantea (soft corals) [GN:dgt]
Gene
114519981  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114539432  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114539433  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114538336  serine--pyruvate aminotransferase, mitochondrial-like isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
114541664  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
114526543  glycerate kinase-like isoform X1 [KO:K11529] [EC:2.7.1.165]
114516156  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
114515985  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114522875  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
114523693  LOW QUALITY PROTEIN: phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
114523175  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
114537845  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
114528841  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
114521902  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
114543544  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
114524746  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
114524747  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
114524749  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
114529174  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
114526337  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
114521752  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
114521513  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
114517004  uncharacterized protein LOC114517004 [KO:K02437]
114531568  D-aspartate oxidase-like [KO:K00273] [EC:1.4.3.3]
114525721  D-aspartate oxidase-like [KO:K00273] [EC:1.4.3.3]
114517030  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114525297  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
114525311  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
114525312  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
114525313  guanidinoacetate N-methyltransferase-like [KO:K00542] [EC:2.1.1.2]
114535944  choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]
114544769  choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]
114529315  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114541012  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114518175  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
114533873  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
114540583  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
114533878  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
114523574  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
114523575  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
114530955  sarcosine dehydrogenase, mitochondrial-like [KO:K00314] [EC:1.5.8.3]
114520307  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
114528080  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
114527107  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
114539438  uncharacterized protein LOC114539438 [KO:K01754] [EC:4.3.1.19]
114527795  uncharacterized protein LOC114527795 [KO:K01754] [EC:4.3.1.19]
114520351  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
114531621  uncharacterized protein LOC114531621 isoform X1 [KO:K20498] [EC:4.3.1.18]
114523541  probable serine racemase [KO:K12235] [EC:5.1.1.18]
114523542  serine racemase-like [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
dgt00010  Glycolysis / Gluconeogenesis
dgt00020  Citrate cycle (TCA cycle)
dgt00230  Purine metabolism
dgt00250  Alanine, aspartate and glutamate metabolism
dgt00270  Cysteine and methionine metabolism
dgt00290  Valine, leucine and isoleucine biosynthesis
dgt00330  Arginine and proline metabolism
dgt00470  D-Amino acid metabolism
dgt00564  Glycerophospholipid metabolism
dgt00600  Sphingolipid metabolism
dgt00620  Pyruvate metabolism
dgt00630  Glyoxylate and dicarboxylate metabolism
dgt00640  Propanoate metabolism
dgt00860  Porphyrin metabolism
dgt00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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