Entry
Name
Cysteine and methionine metabolism - Oryza sativa japonica (Japanese rice) (RAPDB)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:
M00021 ]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:
M00338 ]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:
M00017 ]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:
M00034 ].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Oryza sativa japonica (Japanese rice) (RAPDB) [GN:
dosa ]
Gene
Os03t0747800-01 (RAP-DB) Os03g0747800; Cysteine synthase (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O- acetylserine (Thiol)-lyase) (CSase) (OAS-TL). [KO:K01738 ] [EC:2.5.1.47 ]
Os01t0978100-01 (RAP-DB) Os01g0978100; Similar to Cysteine synthase, mitochondrial precursor (EC 2.5.1.47) (O- acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase C) (CS-C) (OAS-TL C) (AtCS-C). [KO:K01738 ] [EC:2.5.1.47 ]
Os06t0175800-01 (RAP-DB) Os06g0175800; Similar to Cystathionine beta-lyase, chloroplast precursor (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase). [KO:K01760 ] [EC:4.4.1.13 ]
Os03t0221200-01 (RAP-DB) Os03g0221200; Similar to Homocysteine S-methyltransferase 1 (EC 2.1.1.10) (S- methylmethionine:homocysteine methyltransferase 1) (SMM:Hcy S- methyltransferase 1) (ZmHMT-1). [KO:K00547 ] [EC:2.1.1.10 ]
Os01t0772900-01 (RAP-DB) Os01g0772900; Similar to Homocysteine S-methyltransferase 4 (EC 2.1.1.10) (S- methylmethionine:homocysteine methyltransferase 4) (SMM:Hcy S- methyltransferase 4) (ZmHMT-4). [KO:K00547 ] [EC:2.1.1.10 ]
Os10t0422200-01 (RAP-DB) Os10g0422200; Similar to Homocysteine S-methyltransferase 3 (EC 2.1.1.10) (S- methylmethionine:homocysteine methyltransferase 3) (SMM:Hcy S- methyltransferase 3) (ZmHMT-3). [KO:K00547 ] [EC:2.1.1.10 ]
Os01t0293000-01 (RAP-DB) Os01g0293000; Similar to S-adenosylmethionine synthetase 1 (EC 2.5.1.6) (Methionine adenosyltransferase 1) (AdoMet synthetase 1) (Fragment). [KO:K00789 ] [EC:2.5.1.6 ]
Os05t0135700-01 (RAP-DB) Os05g0135700; S-adenosylmethionine synthetase 1 (EC 2.5.1.6) (Methionine adenosyltransferase 1) (AdoMet synthetase 1). [KO:K00789 ] [EC:2.5.1.6 ]
Os02t0611200-01 (RAP-DB) Os02g0611200; Similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) (AdoMetDC) (SamDC) (Induced stolen tip protein TUB13) [Contains: S- adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]. [KO:K01611 ] [EC:4.1.1.50 ]
Os04t0498600-01 (RAP-DB) Os04g0498600; Similar to S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50) (AdoMetDC) (SamDC). [KO:K01611 ] [EC:4.1.1.50 ]
Os07t0408700-02 (RAP-DB) Os07g0408700; Similar to Spermidine synthase 2 (EC 2.5.1.16) (Putrescine aminopropyltransferase 2) (SPDSY 2). [KO:K00797 ] [EC:2.5.1.16 ]
Os03t0307300-01 (RAP-DB) Os03g0307300; Nicotianamine synthase 1 (EC 2.5.1.43) (S-adenosyl-L-methionine:S- adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3- carboxypropyltransferase 1) (OsNAS1). [KO:K05953 ] [EC:2.5.1.43 ]
Os07t0689600-01 (RAP-DB) Os07g0689600; Nicotianamine synthase 3 (EC 2.5.1.43) (S-adenosyl-L-methionine:S- adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3- carboxypropyltransferase 3) (OsNAS3). [KO:K05953 ] [EC:2.5.1.43 ]
Os11t0644800-00 (RAP-DB) Os11g0644800; Similar to Tyrosine/nicotianamine aminotransferases family protein, expressed. [KO:K00815 ] [EC:2.6.1.5 ]
Os01t0178000-01 (RAP-DB) Os01g0178000; Pyridoxal phosphate-dependent transferase, major region, subdomain 1 domain containing protein. [KO:K00837 ] [EC:2.6.1.-]
Os10t0517500-02 (RAP-DB) Os10g0517500; Cys/Met metabolism, pyridoxal phosphate-dependent enzyme domain containing protein. [KO:K01761 ] [EC:4.4.1.11 ]
Os03t0727600-01 (RAP-DB) Os03g0727600; 1-aminocyclopropane-1-carboxylate synthase 1 (EC 4.4.1.14) (ACC synthase 1) (S-adenosyl-L-methionine methylthioadenosine-lyase 1). [KO:K01762 ] [EC:4.4.1.14 ]
Os11t0186900-01 (RAP-DB) Os11g0186900; Similar to 1-aminocyclopropane-1-carboxylate oxidase (EC 1.14.17.4) (ACC oxidase) (Ethylene-forming enzyme) (EFE). [KO:K05933 ] [EC:1.14.17.4 ]
Os09t0451000-01 (RAP-DB) Os09g0451000; Similar to 1-aminocyclopropane-1-carboxylate oxidase 1 (EC 1.14.17.4) (ACC oxidase 1) (Ethylene-forming enzyme) (EFE). [KO:K05933 ] [EC:1.14.17.4 ]
Os09t0451400-01 (RAP-DB) Os09g0451400; 1-aminocyclopropane-1-carboxylate oxidase 1 (EC 1.14.17.4) (ACC oxidase 1) (Ethylene-forming enzyme) (EFE). [KO:K05933 ] [EC:1.14.17.4 ]
Os09t0294000-01 (RAP-DB) Os09g0294000; Similar to Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplast precursor (AK-HD 2) (AK-HSDH 2) [Includes: Aspartokinase (EC 2.7.2.4 ); Homoserine dehydrogenase (EC 1.1.1.3 )]. [KO:K12524 ] [EC:2.7.2.4 1.1.1.3 ]
Os04t0559400-01 (RAP-DB) Os04g0559400; Similar to Branched-chain-amino-acid aminotransferase 5, chloroplast precursor (EC 2.6.1.42) (Atbcat-5). [KO:K00826 ] [EC:2.6.1.42 ]
Os03t0106400-01 (RAP-DB) Os03g0106400; Similar to Branched-chain-amino-acid aminotransferase 5, chloroplast precursor (EC 2.6.1.42) (Atbcat-5). [KO:K00826 ] [EC:2.6.1.42 ]
Os03t0231600-01 (RAP-DB) Os03g0231600; Similar to Branched-chain-amino-acid aminotransferase 3, chloroplast precursor (EC 2.6.1.42) (Atbcat-3). [KO:K00826 ] [EC:2.6.1.42 ]
Os05t0558400-01 (RAP-DB) Os05g0558400; Similar to Branched-chain-amino-acid aminotransferase 3, chloroplast precursor (EC 2.6.1.42) (Atbcat-3). [KO:K00826 ] [EC:2.6.1.42 ]
Os12t0608600-01 (RAP-DB) Os12g0608600; Similar to Thiosulfate sulfurtransferase (EC 2.8.1.1) (Mercaptopyruvate sulfurtransferase Mst2/Rdh2) (EC 2.8.1.2). [KO:K01011 ] [EC:2.8.1.1 2.8.1.2 ]
Os01t0290100-01 (RAP-DB) Os01g0290100; Pyridoxal phosphate-dependent transferase, major region, subdomain 1 domain containing protein. [KO:K22207 ] [EC:4.4.1.28 ]
Os03t0773800-01 (RAP-DB) Os03g0773800; Similar to Malate dehydrogenase, glyoxysomal precursor (EC 1.1.1.37) (mbNAD-MDH). [KO:K00026 ] [EC:1.1.1.37 ]
Os01t0814800-01 (RAP-DB) Os01g0814800; Similar to Cysteine synthase, chloroplast precursor (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase B) (CS-B) (OAS-TL B). [KO:K22846 ] [EC:2.5.1.144 ]
Compound
C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00441 L-Aspartate 4-semialdehyde
C01118 O-Succinyl-L-homoserine
C01137 S-Adenosylmethioninamine
C01180 4-Methylthio-2-oxobutanoic acid
C01234 1-Aminocyclopropane-1-carboxylate
C03431 S-Inosyl-L-homocysteine
C03539 S-Ribosyl-L-homocysteine
C04188 S-Methyl-5-thio-D-ribose 1-phosphate
C04582 S-Methyl-5-thio-D-ribulose 1-phosphate
C05526 S-Glutathionyl-L-cysteine
C08276 3-(Methylthio)propanoate
C11437 1-Deoxy-D-xylulose 5-phosphate
C15606 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650 2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651 2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049 N-Acyl-L-homoserine lactone
C19787 5'-S-Methyl-5'-thioinosine
C21015 gamma-L-Glutamyl-L-2-aminobutyrate
C22359 S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
Title
Bacterial variations on the methionine salvage pathway.
Journal
Reference
Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
Journal
Reference
Authors
Sekowska A, Danchin A.
Title
The methionine salvage pathway in Bacillus subtilis.
Journal
Reference
Authors
Berger BJ, English S, Chan G, Knodel MH.
Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
Journal
Reference
Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
Journal
Reference
Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
Journal
Reference
Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
Journal
Reference
Authors
Ashida H, Saito Y, Kojima C, Yokota A
Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
Journal
Reference
Authors
Kitabatake M, So MW, Tumbula DL, Soll D
Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
Journal
Reference
Authors
Mino K, Ishikawa K
Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
Journal
Reference
Authors
Tanabe S
Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
Journal
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Journal
Related pathway
dosa00250 Alanine, aspartate and glutamate metabolism
dosa00260 Glycine, serine and threonine metabolism
dosa00290 Valine, leucine and isoleucine biosynthesis
KO pathway
LinkDB
All DBs