KEGG   PATHWAY: dre00830
Entry
dre00830                    Pathway                                
Name
Retinol metabolism - Danio rerio (zebrafish)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
dre00830  Retinol metabolism
dre00830

Other DBs
GO: 0006776
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
84039  bco1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
393580  bco1l; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
116517  adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
322482  adh8a; alcohol dehydrogenase 8a [KO:K00121] [EC:1.1.1.284 1.1.1.1]
393427  adh5l; Alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
402841  adh8b; alcohol dehydrogenase 8b [KO:K00121] [EC:1.1.1.284 1.1.1.1]
402939  zgc:77938; Alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
445083  dhrs3a; short-chain dehydrogenase/reductase 3a [KO:K11146] [EC:1.1.1.300]
450050  dhrs3b; short-chain dehydrogenase/reductase 3b [KO:K11146] [EC:1.1.1.300]
393539  dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
280648  rdh8a; retinol dehydrogenase 8a [KO:K11150] [EC:1.1.1.-]
553564  zgc:109982; uncharacterized protein LOC553564 [KO:K11150] [EC:1.1.1.-]
556557  zmp:0000001048; retinol dehydrogenase 8-like isoform X1 [KO:K11150] [EC:1.1.1.-]
393761  rdh8b; retinol dehydrogenase 8b [KO:K11150] [EC:1.1.1.-]
555864  rdh20; retinol dehydrogenase 10-like [KO:K11151] [EC:1.1.1.-]
562840  rdh10a; retinol dehydrogenase 10-A [KO:K11151] [EC:1.1.1.-]
378722  rdh10b; retinol dehydrogenase 10-B [KO:K11151] [EC:1.1.1.-]
436597  rdh12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
407663  si:ch211-107o10.3; uncharacterized protein LOC407663 [KO:K11153] [EC:1.1.1.300]
561542  si:dkey-23o4.6; retinol dehydrogenase 12-like isoform X2 [KO:K11153] [EC:1.1.1.300]
553712  zgc:112332; uncharacterized protein LOC553712 [KO:K11153] [EC:1.1.1.300]
100141353  si:dkey-94e7.2; uncharacterized protein LOC100141353 [KO:K11153] [EC:1.1.1.300]
100150965  si:dkey-73n8.3; uncharacterized protein LOC100150965 [KO:K11153] [EC:1.1.1.300]
494176  rdh12l; retinol dehydrogenase 12, like [KO:K11153] [EC:1.1.1.300]
751745  zgc:153441; retinol-DH_like_SDR_c domain-containing protein [KO:K11153] [EC:1.1.1.300]
406799  sdr16c5b; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
405814  sdr16c5a; short chain dehydrogenase/reductase family 16C, member 5a [KO:K15734] [EC:1.1.1.105]
563950  si:dkey-221h15.4; uncharacterized protein LOC563950 [KO:K15734] [EC:1.1.1.105]
553501  lratb; lecithin retinol acyltransferase isoform X3 [KO:K00678] [EC:2.3.1.135]
553239  lrata; lecithin retinol acyltransferase a [KO:K00678] [EC:2.3.1.135]
566123  si:dkey-30k22.5; lecithin retinol acyltransferase family protein [KO:K00678] [EC:2.3.1.135]
556575  lratb.2; lecithin retinol acyltransferase b, tandem duplicate 2 precursor [KO:K00678] [EC:2.3.1.135]
325875  dgat1a; diacylglycerol O-acyltransferase 1a [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
436731  dgat1b; diacylglycerol O-acyltransferase 1b [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
100037326  pnpla4; patatin-like phospholipase domain-containing protein 4 [KO:K11157] [EC:3.1.1.-]
100004076  rpe65c; retinal Mueller cells isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
393724  rpe65a; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
556528  rdh5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
570457  aox6; aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
64265  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
116713  aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
751785  aldh1a3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
30381  cyp26a1; cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
324188  cyp26b1; cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
554036  cyp26c1; cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
553969  cyp3a65; cytochrome P450, family 3, subfamily A, polypeptide 65 [KO:K07424] [EC:1.14.14.1]
324340  cyp3c1; cytochrome P450, family 3, subfamily c, polypeptide 1 [KO:K07424] [EC:1.14.14.1]
492759  cyp3c3; cytochrome P450 3C3 [KO:K07424] [EC:1.14.14.1]
558473  cyp3c2; cytochrome P450 3A19-like isoform X2 [KO:K07424] [EC:1.14.14.1]
558541  cyp3c4; cytochrome P450 3C4 [KO:K07424] [EC:1.14.14.1]
406731  ugt1ab; UDP glucuronosyltransferase 1 family a, b precursor [KO:K00699] [EC:2.4.1.17]
570913  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 precursor [KO:K00699] [EC:2.4.1.17]
553952  ugt2a2; UDP-glucuronosyltransferase 2A2 precursor [KO:K00699] [EC:2.4.1.17]
641488  ugt1a1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
767705  ugt2a5; UDP glucuronosyltransferase 2 family, polypeptide A5 precursor [KO:K00699] [EC:2.4.1.17]
100006320  ugt2a1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
100415797  ugt5a5; UDP glucuronosyltransferase 5 family, polypeptide A5 precursor [KO:K00699] [EC:2.4.1.17]
767756  ugt5a2; UDP glucuronosyltransferase 5 family, polypeptide A2 precursor [KO:K00699] [EC:2.4.1.17]
100415798  ugt5a4; UDP glucuronosyltransferase 5 family, polypeptide A4 precursor [KO:K00699] [EC:2.4.1.17]
100415799  ugt5b2; UDP glucuronosyltransferase 5 family, polypeptide B2 precursor [KO:K00699] [EC:2.4.1.17]
556049  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 precursor [KO:K00699] [EC:2.4.1.17]
100379286  ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 precursor [KO:K00699] [EC:2.4.1.17]
322378  ugt5a3; UDP glucuronosyltransferase 5 family, polypeptide A3 precursor [KO:K00699] [EC:2.4.1.17]
792506  ugt2b6; UDP glucuronosyltransferase 2 family, polypeptide B6 precursor [KO:K00699] [EC:2.4.1.17]
795050  ugt1b4; UDP glucuronosyltransferase 1 family, polypeptide B4 [KO:K00699] [EC:2.4.1.17]
791613  ugt2a4; UDP glucuronosyltransferase 2 family, polypeptide A4 precursor [KO:K00699] [EC:2.4.1.17]
797211  ugt2a6; UDP glucuronosyltransferase 2 family, polypeptide A6 precursor [KO:K00699] [EC:2.4.1.17]
100002993  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 precursor [KO:K00699] [EC:2.4.1.17]
751669  ugt5c2; UDP glucuronosyltransferase 5 family, polypeptide C2 [KO:K00699] [EC:2.4.1.17]
100384893  ugt1b2; UDP glucuronosyltransferase 1 family, polypeptide B2 precursor [KO:K00699] [EC:2.4.1.17]
100384896  ugt1a6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
100384891  ugt1a7; UDP-glucuronosyltransferase 1-7 precursor [KO:K00699] [EC:2.4.1.17]
100384895  ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
100384897  ugt1a5; UDP-glucuronosyltransferase 1-5 precursor [KO:K00699] [EC:2.4.1.17]
100384898  ugt2b3; UDP glucuronosyltransferase 2 family, polypeptide B3 isoform 2 precursor [KO:K00699] [EC:2.4.1.17]
100384901  ugt1a4; UDP-glucuronosyltransferase 1-4 precursor [KO:K00699] [EC:2.4.1.17]
100384902  ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 precursor [KO:K00699] [EC:2.4.1.17]
100384903  ugt1b3; UDP glucuronosyltransferase 1 family, polypeptide B3 precursor [KO:K00699] [EC:2.4.1.17]
100415791  ugt5b1; UDP glucuronosyltransferase 5 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
100415792  ugt5b3; UDP glucuronosyltransferase 5 family, polypeptide B3 precursor [KO:K00699] [EC:2.4.1.17]
100415794  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
100415800  ugt5f1; UDP glucuronosyltransferase 5 family, polypeptide F1 precursor [KO:K00699] [EC:2.4.1.17]
100384899  ugt1b5; UDP glucuronosyltransferase 1 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
641479  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 precursor [KO:K00699] [EC:2.4.1.17]
678597  ugt5b6; UDP glucuronosyltransferase 5 family, polypeptide B6 precursor [KO:K00699] [EC:2.4.1.17]
558508  ugt1b1; UDP glucuronosyltransferase 1 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
791210  ugt5b4; UDP glucuronosyltransferase 5 family, polypeptide B4 precursor [KO:K00699] [EC:2.4.1.17]
795261  ugt1b7; UDP glucuronosyltransferase 1 family, polypeptide B7 precursor [KO:K00699] [EC:2.4.1.17]
325922  retsat.2; all-trans-retinol 13,14-reductase precursor [KO:K09516] [EC:1.3.99.23]
677660  retsatl; inactive all-trans-retinol 13,14-reductase precursor [KO:K09516] [EC:1.3.99.23]
777751  retsat.1; Putative all-trans-retinol 13,14-reductase-like precursor [KO:K09516] [EC:1.3.99.23]
563241  si:ch1073-13h15.3; putative all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
558396  cyp27c1; cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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